Comparing the content of lipids derived from the eye lenses of various species

Panz, Tomasz; Lepiarczyk, Magdalena; Zuber, Agnieszka

doi:10.5603/fhc.2011.0060

Cited by 4 publications

(2 citation statements)

References 11 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study shows that PL composition of SF can markedly differ between these two mammalian species, a profile that has also been shown for plasma [40,41]. Differing PL profiles among vertebrates were also described for erythrocyte membranes and tissues such as the eye, heart and brain, all of which also depend on health status and differences in enzymatic activity [18,[40][41][42][43][44][45][46].…”

Section: Plos Onesupporting

confidence: 77%

A comparative study on the lipidome of normal knee synovial fluid from humans and horses

et al. 2021

View full text Add to dashboard Cite

The current limitations in evaluating synovial fluid (SF) components in health and disease and between species are due in part to the lack of data on normal SF, because of low availability of SF from healthy articular joints. Our study aimed to quantify species-dependent differences in phospholipid (PL) profiles of normal knee SF obtained from equine and human donors. Knee SF was obtained during autopsy by arthrocentesis from 15 and 13 joint-healthy human and equine donors, respectively. PL species extracted from SF were quantitated by mass spectrometry whereas ELISA determined apolipoprotein (Apo) B-100. Wilcoxon’s rank sum test with adjustment of scores for tied values was applied followed by Holm´s method to account for multiple testing. Six lipid classes with 89 PL species were quantified, namely phosphatidylcholine, lysophosphatidylcholine, sphingomyelin, phosphatidylethanolamine, plasmalogen, and ceramide. Importantly, equine SF contains about half of the PL content determined in human SF with some characteristic changes in PL composition. Nutritional habits, decreased apolipoprotein levels and altered enzymatic activities may have caused the observed different PL profiles. Our study provides comprehensive quantitative data on PL species levels in normal human and equine knee SF so that research in joint diseases and articular lubrication can be facilitated.

show abstract

Section: Plos Onesupporting

confidence: 77%

A comparative study on the lipidome of normal knee synovial fluid from humans and horses

et al. 2021

View full text Add to dashboard Cite

show abstract

“…On basis of the observations, it can be suggested that these fatty acids collectively or individually can act as biomarkers of aging lens. Since these fatty acids are present in the aging lens and three of them are known to have beneficial role, perhaps the ophthalmic preparations containing such substances could be good for keeping the lens healthy; however, it is necessary to check whether these fatty acids are also present in aging human lens since there are species variations in lens lipid composition [23].…”

Section: Discussionmentioning

confidence: 99%

Lipid Biomarkers of Lens Aging

Mohanty

Bhattacharjee

Paria

et al. 2012

Appl Biochem Biotechnol

View full text Add to dashboard Cite

Lipids are important structural components of cell membranes and have profound effect on membrane fluidity. Lipid profiling and lipidomics have captured increased attention due to the well-recognized roles of lipids in numerous human diseases. Investigating lipid profiles not only provides insights into the specific roles of lipid molecular species in health and diseases, but can also help in identifying potential preventive or therapeutic biomarkers. Cataract, the loss of transparency of eye lens, is a disease of protein aggregation. There are several factors contributing to the stability in protein conformation. Age-related changes in lipid composition could be a contributing factor for altered protein-lipid interaction leading to protein aggregation and cataract. Keeping this in view, in the present study, fatty acid profiling from different age groups of lenses was carried out, using a freshwater catfish as the model. Total lipids were extracted from lenses of three different age groups of fishes (young, adult, and aged) and fatty acid methyl esters (FAME) were prepared and FAME analysis was carried out using gas chromatography-mass spectrometry. The results showed that three fatty acids viz. heneicosylic acid (C21), docosahexaenoic acid (C22:6), nervonic acid (C24:1) which were not present in the adult lens, appeared in the aged lens. On the other hand, eicosenoic acid (C20:1) present in the adult lens was found to be absent in the aged lens. The appearance or disappearance of these fatty acids can possibly serve as biomarkers of aging lens which is the most vulnerable stage for cataract development.

show abstract

GM3 Interacts with TGFβRs in the Epithelial–Mesenchymal Transition (EMT) During Posterior Capsular Opacification (PCO) Formation

Kim

2020

GM3 Signaling

View full text Add to dashboard Cite

Comparing the content of lipids derived from the eye lenses of various species

Cited by 4 publications

References 11 publications

A comparative study on the lipidome of normal knee synovial fluid from humans and horses

A comparative study on the lipidome of normal knee synovial fluid from humans and horses

Lipid Biomarkers of Lens Aging

GM3 Interacts with TGFβRs in the Epithelial–Mesenchymal Transition (EMT) During Posterior Capsular Opacification (PCO) Formation

Contact Info

Product

Resources

About