Comparing Technologies of Additive Manufacturing for the Development of Modular Dosimetry Phantoms in Radiation Therapy

Wegner, Marie; Spallek, Johanna; Krause, Dieter; Gargioni, E.

doi:10.18416/ammm.2020.2009028

Cited by 5 publications

(5 citation statements)

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“…As a second step, we chose appropriate AM materials for CT based on our previous work, during which we analysed five different AM processes with sixteen different printing materials (Wegner et al 2020). These AM procedures comprised powder bed, light polymerization, and material extrusion processes.…”

Section: Materials Choicementioning

confidence: 99%

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Development and characterization of modular mouse phantoms for end-to-end testing and training in radiobiology experiments

Wegner

Frenzel²,

Krause³

et al. 2023

Phys. Med. Biol.

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Objective. In radiation oncology, experiments are often carried out using mice as a model for in-vivo research studies. Due to recent technological advances in the development of high-precision small-animal irradiation facilities, the importance of quality assurance for both dosimetry and imaging is increasing. Additive manufacturing (AM) offers the possibility to produce complex models from a three-dimensional data set and to build cost-effective phantoms that can easily be adapted to different purposes. The aim of this work was therefore to develop detailed anatomical mouse models for quality assurance and end-to-end testing of small-animal irradiation and imaging by means of AM. Approach. Two mouse phantom concepts were designed, constructed, and examined for this purpose. The first model includes cavities corresponding to the most important organs. The final solid model was constructed using AM in two separate parts that can be attached with a plug connection after filling these cavities with tissue-equivalent mixtures. Moreover, different radiation dosimeters can be placed in the lower part of the model. For the second concept, AM was used for building modules like the phantom outer shell and bones, so that different mixtures can be used as a filling, without modifying the phantom structure. Main results. CT as well as Micro-CT scans of both concepts showed an excellent quality and adequate image contrast, with material attenuation properties close to those of mouse tissues, apart from the current bone surrogates. Radiation dose measurements with radiochromic films were, with some exceptions in areas with larges bone volumes, in agreement with calculations within less than ± 4 %. Significance. AM shows great potential for the development of mouse models that are inexpensive, easy to adapt, and accurate, thus enabling their use for quality assurance in small-animal radiotherapy and imaging. The introduction of such 3D-printable mouse phantoms in the workflow could also significantly reduce the use of living animals for optimization and testing of new imaging and irradiation protocols.

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Section: Materials Choicementioning

confidence: 99%

“…The same Table 1. Properties of the AM materials chosen to manufacture the phantoms during this work, together with respective printing resolution (Spallek et al 2016, Wegner et al 2020. Sample volume: 1.37 cm 3 .…”

Section: Materials Choicementioning

confidence: 99%

Development and characterization of modular mouse phantoms for end-to-end testing and training in radiobiology experiments

Wegner

Frenzel²,

Krause³

et al. 2023

Phys. Med. Biol.

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“…To enable a proper quality assurance and study new approaches in radiotherapy phantoms, with tissue equivalent properties are needed (Wegner et al, 2020). The key to a phantom is the tissue-equivalent material (also called surrogate), which has different properties corresponding to medical imaging modality used.…”

Section: Approach For the Development Of Additively Manufactured Medi...mentioning

confidence: 99%

“…The key to a phantom is the tissue-equivalent material (also called surrogate), which has different properties corresponding to medical imaging modality used. To manufacture phantoms for medical imaging AM can be used for directly printing the material (Silvestro et al, 2020;Wegner et al, 2020). But there are limitations especially when the imaging properties require properties that can't at the moment be fulfilled by AM.…”

Section: Approach For the Development Of Additively Manufactured Medi...mentioning

confidence: 99%

New Trends in Aviation and Medical Technology Enabled by Additive Manufacturing

Wegner

Hartwich

Heyden

et al. 2022

Front. Manuf. Technol.

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In this publication, the potentials of additive manufacturing in the field of sustainability and individualization for aviation and medical technology are presented. Design approaches for each application field as well as examples in the fields are shown. In the field of aviation, structures can be manufactured so that they are load path optimized. This has a great lightweight potential and results in a low resource consumption. The examples contain the design of an aircraft cabin partition using the Direct Energy Deposition process and the optimization of load introduction points directly integrated into the sandwich core. Furthermore, in medical technology, additive manufacturing can be used to produce patient-specific models based on original medical imaging data, which can be used for training of medical treatments, quality assurance or for the validation of new developed medical devices. As examples a stroke simulation model containing a modular aortic model as well as functional stenose models are shown. Furthermore, the use of AM molds to generate a deformable bladder shell and a prostate phantom are described.

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“…Additive manufacturing processes (AM) of phantoms using tissue-equivalent materials are at the core of this development and have been discussed before [ 5 , 6 , 7 , 8 ]. They allow the reliable reproduction of a standardized biological environment suitable to obtain replicates of biological data to obtain statistical power, aiming to answer a specific set of questions.…”

Section: Introductionmentioning

confidence: 99%

A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study

et al. 2023

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The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.

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Comparing Technologies of Additive Manufacturing for the Development of Modular Dosimetry Phantoms in Radiation Therapy

Cited by 5 publications

References 0 publications

Development and characterization of modular mouse phantoms for end-to-end testing and training in radiobiology experiments

Development and characterization of modular mouse phantoms for end-to-end testing and training in radiobiology experiments

New Trends in Aviation and Medical Technology Enabled by Additive Manufacturing

A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study

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