Comparing Tear Film Viscosity between Sjögren and Non-Sjögren Dry Eye Disease

Abstract

This study aimed to compare tear film viscosity (TFV) in Sjögren and non-Sjögren dry eye diseases (DEDs). This was a cross-sectional observational study. A total of 68 DED patients were enrolled, including 32 patients with Sjögren syndrome (SS) and 36 without SS. TFV was assessed by a tear film analyzer and determined by the momentary moving speed (MMS; MMS (t) = α × t−β, t = time (s)) with its power-law fitting-derived parameters (α and β). Among the four indices of TFV (MMS (0.1 s), MMS (2.0 s), α, and β), the SS-DED patients had significantly lower MMS (0.1 s) (p = 2.01 × 10−5), α (p = 0.0375), and β (p = 0.0076). The SS-DED group also had significantly higher OSDI, lower central and nasal tear meniscus height (TMH), and higher OSS. MMS (0.1 s) was significantly correlated with nasal TMH and OSS (ρ = 0.2520, p = 0.0381 in nasal TMH; ρ = −0.3487, p = 0.0036 in OSS). Index β was not correlated with any non-TFV tests. In conclusion, MMS (0.1 s), α, and β are promising TFV indices in distinguishing SS-DED from non-SS-DED patients early. Among these TFV indices, lower MMS is the best alternative clue for detecting SS-DED.

A randomized controlled trial involving college student: Comparing 0.15% hyaluronic acid with 0.05% cyclosporine A and 3% diquafosol sodium in the Treatment of Dry Eye

“…[28] TMH is considered to be the most useful method to provide indirect measurement of tear film volume. [29][30] All 3 groups improved, but there was no significant difference between groups in our study. TBUT is commonly used to evaluate tear film stability.…”

Surface Chemistry Study of Normal and Diseased Human Meibum Films Prior to and after Supplementation with Tear Mimetic Eyedrop Formulation

“…The formulation additionally endeavors to enhance the secretory-mucin-rich gel layer of human tears by incorporating polyvinylpyrrolidone, a polymer that is believed to augment the tear film's shear thinning properties [35][36][37][38][39][40]. These properties are crucial for the lubricating action of TF during blinking, as well as for its tensile strength when at interblink [41][42][43][44].…”