Comparing Symptoms of Chronic Fatigue Syndrome in a Community-Based Versus                Tertiary Care Sample

Jason, Leonard A.; Plioplys, Audrius V.; Torres-Harding, Susan; Corradi, Karina

doi:10.1177/13591053030084005

Cited by 15 publications

(11 citation statements)

References 12 publications

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“…[46] In a CDC community-based epidemiology study in Wichita, Kansas [5], Nisenbaum et al [47] provided percentages of symptoms for 65 individuals classified as having CFS. Unusual fatigue post-exertion was found in 78.5%, and difficulty thinking/concentrating or memory problems was found in 76.9%.…”

Section: Discussionmentioning

confidence: 99%

Case definitions integrating empiric and consensus perspectives

Jason

McManimen

Sunnquist

et al. 2016

Fatigue: Biomedicine, Health & Behavior

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Background There has been considerable controversy regarding how to name and define the illnesses known as myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS). The IOM report has proposed a new clinical criteria and name for this illness, but aspects of these recommendations have been scrutinized by patients and scientists. Purpose It is possible that both empiric and consensus approaches could be used to help settle some of these diagnostic challenges. Using patient samples collected in the United States, Great Britain, and Norway (N=556), the current study attempted to categorize patients using more general as well as more restricted case definitions. Results Overall, the outcomes suggest that there might be four groupings of patients, with the broadest category involving those with chronic fatigue (N=62), defined by 6 or more months of fatigue which can be cannot be explained by medical or psychiatric conditions. A second category involves those patients that have chronic fatigue that can be explained by a medical or psychiatric condition (N=47). A third category involves more specific criteria that have been posited both by the IOM report, a Canadian Clinical Case criteria, a ME-ICC criteria and a more empiric approach. These efforts have specified domains of substantial reductions of activity, post-exertional malaise, neurocognitive impairment, and sleep dysfunction (N=346). Patients with these characteristics were more functionally impaired than those meeting just chronic fatigue criteria, p < .05. Finally, those meeting even more restrictive ME criteria proposed by Ramsay, identified a smaller and even more impaired group, p < .05. Discussion The advantages of using such empirical and consensus approaches to develop reliable classification and diagnostic efforts are discussed.

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Section: Discussionmentioning

confidence: 99%

Case definitions integrating empiric and consensus perspectives

Jason

McManimen

Sunnquist

et al. 2016

Fatigue: Biomedicine, Health & Behavior

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“…3 In contrast to the Fukuda criteria, the Canadian criteria selected cases with less psychiatric comorbidity, more physical functional impairment, more fatigue/weakness, and more neurological symptoms. 11 Two recent studies again showed that patients meeting the Canadian criteria had more functional impairments and more severe physical and cognitive symptoms than the subgroup only meeting the Fukuda criteria. 12 Other sets of criteria are the Oxford criteria (1991) and the Australian criteria (1990).…”

Section: Diagnostic Criteriamentioning

confidence: 98%

“…The revised literature does not provide specific detailed information about the most preferred CBT methodology. There are a lot of differences concerning the number of sessions (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16), the session length (30-150 min) and the frequency of the sessions. 59 Furthermore, there is a great variation in the characteristics of the therapists.…”

Section: Therapymentioning

confidence: 99%

Chronic fatigue syndrome – an update

Rimbaut

Gutte

Brabander

et al. 2016

Acta Clinica Belgica

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Despite extensive research, none of the proposed etiological factors have shown strong, reproducible scientific evidence. Over the years, the biopsychosocial model integrating many of the proposed hypotheses has been gaining popularity over the biomedical model, where the focus is on one physical cause. Since the etiological mechanism underlying chronic fatigue syndrome is currently unknown, disease-specific treatments do not exist. Various treatments have been investigated but only cognitive behavior therapy (CBT) and graded exercise therapy (GET) have shown moderate effectiveness.

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“…Reports suggested increased risk of cancer as well as suicide [10], [11]. CFS affects all ethnic groups and socio-economic strata of society though at least 2 to 4 times as many women as men suffer from this illness [3], [12], [13]. Diagnosis using the case definition [1] requires the exclusion of any other medical explanation for these symptoms, yielding an inefficient, slow, error prone process.…”

Section: Introductionmentioning

confidence: 99%

“…There is a considerable literature describing immune dysfunction in CFS [14]–[16], although reviews of the immunology of CFS noted that universal agreement of immunological abnormalities had not been achieved, in no small part due to differences in methodologies, case definition and study quality [17], [18]. However, redundant reports support 1) reduced function of natural killer (NK) cells [14], [19] with deficiencies of perforin and granzymes in both NK cells and CD8 T cells [20]; 2) inflammation [21], [22]; 3) altered cytokine profiles [9], [10] with elevation of proinflammatory cytokines [11], [12] and Th2 (T helper cell type 2) polarization [11], [13]; and 4) chronic lymphocyte activation [14], [16].…”

Section: Introductionmentioning

confidence: 99%

Biomarkers in Chronic Fatigue Syndrome: Evaluation of Natural Killer Cell Function and Dipeptidyl Peptidase IV/CD26

et al. 2010

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BackgroundChronic Fatigue Syndrome (CFS) studies from our laboratory and others described decreased natural killer cell cytotoxicity (NKCC) and elevated proportion of lymphocytes expressing the activation marker, dipeptidyl peptidase IV (DPPIV) also known as CD26. However, neither these assays nor other laboratory tests are widely accepted for the diagnosis or prognosis of CFS. This study sought to determine if NKCC or DPPIV/CD26 have diagnostic accuracy for CFS.Methods/ResultsSubjects included female and male CFS cases and healthy controls. NK cell function was measured with a bioassay, using K562 cells and 51Cr release. Lymphocyte associated DPPIV/CD26 was assayed by qualitative and quantitative flow cytometry. Serum DPPIV/CD26 was measured by ELISA. Analysis by receiver operating characteristic (ROC) curve assessed biomarker potential. Cytotoxic function of NK cells for 176 CFS subjects was significantly lower than in the 230 controls. According to ROC analysis, NKCC was a good predictor of CFS status. There was no significant difference in NK cell counts between cases and controls. Percent CD2+ lymphocytes (T cells and NK cells) positive for DPPIV/C26 was elevated in CFS cases, but there was a decrease in the number of molecules (rMol) of DPPIV/C26 expressed on T cells and NK cells and a decrease in the soluble form of the enzyme in serum. Analyses by ROC curves indicated that all three measurements of DPPIV/CD26 demonstrated potential as biomarkers for CFS. None of the DPPIV/C26 assays were significantly correlated with NKCC.ConclusionsBy ROC analysis, NKCC and three methods of measuring DPPIV/C26 examined in this study had potential as biomarkers for CFS. Of these, NKCC, %CD2+CD26+ lymphocytes and rMol CD26/CD2+ lymphocyte, required flow cytometry, fresh blood and access to a high complexity laboratory. Soluble DPPIV/C26 in serum is done with a standard ELISA assay, or with other soluble factors in a multiplex type of ELISA. Dipeptidyl peptidase IV on lymphocytes or in serum was not predictive of NKCC suggesting that these should be considered as non-redundant biomarkers. Abnormalities in DPPIV/CD26 and in NK cell function have particular relevance to the possible role of infection in the initiation and/or the persistence of CFS.

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Comparing Symptoms of Chronic Fatigue Syndrome in a Community-Based Versus Tertiary Care Sample

Cited by 15 publications

References 12 publications

Case definitions integrating empiric and consensus perspectives

Case definitions integrating empiric and consensus perspectives

Chronic fatigue syndrome – an update

Biomarkers in Chronic Fatigue Syndrome: Evaluation of Natural Killer Cell Function and Dipeptidyl Peptidase IV/CD26

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