“…Meanwhile, the developed models just predicted the current outbreak status and were not forward-looking. Many studies have been using a time-series forecasting model to explain, evaluate and estimate the development trends in outbreak human diseases (e.g., , such as the further values of outbreak disease cases, deaths, or transmission rates [18,19]. Besides, XGBoost was proved to have more outstanding prediction accuracy and generalization ability than RF, support vector machines (SVM), k-nearest neighbor (KNN), and back propagation neural network (BPNN) in predicting the risk and outbreaks of diabetes [20], dermatomyositis [21], COVID-19 [14,15], wheat stripe rust [22], and other diseases of human and plants, due to the superiority of its architecture, which also provided a new idea and algorithm for risk/outbreak identification, early intervention, and practical application in animal diseases.…”