Obesity increased dramatically over the last 25 years worldwide. Individual, community, and legislative interventions have been tested. This review examines the effectiveness of regulatory interventions. Method: Between 2005 and 2021, Medline, PubMed, and google scholar were searched for obesity, intervention, outcomes, strategies, healthy eating, and regulatory strategies. One hundred thirty-two papers and reports were identified, and 36 were selected for the current review to describe the outcomes of these strategies based on their effectiveness in reducing obesity rates. Results: Increasing taxes, regulating food marketing, and removing unhealthy food from food assistance programs helped reduce unhealthy food exposure, as did food labeling. Regulatory strategies have reduced consumption or purchase, but weight loss may take a long time to reduce weight. 20% volume-based tax of SSB reduced purchase and consumption with reasonable weight loss. Strategies to increase availability and access to healthy food to food program recipients or food producers showed a positive effect on consumption and weight loss. Price reduction of healthy food or its availability through food programs effectively increased consumption and reduced weight. Although not thoroughly tested, unhealthy food advertising is expected to work for children on the long term. Conclusion: Comprehensive strategies focused on reversing the obesogenic environment still require time to show their effect on weight reduction. However, increased availability and access to healthy food reduced exposure to unhealthy food and promoted physical activity has good potential to reduce obesity.