Comparing polyvalent bacteriophage and bacteriophage cocktails for controlling antibiotic-resistant bacteria in soil-plant system

Zhao, Yuting; Ye, Mao; Zhang, Xinting; Sun, Mingming; Zhang, Zhongyun; Chao, Huizhen; Huang, Dan; Wan, Jiguang; Zhang, Shengtian; Jiang, Xin; Sun, Dawei; Yuan, Youlu; Hu, Feng

doi:10.1016/j.scitotenv.2018.11.457

Cited by 41 publications

(18 citation statements)

References 37 publications

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“…The relative contribution of polyvalent phages vs phage cocktails to bacterial biocontrol remains unclear. However, Zhao et al [16] reported that a polyvalent phage of the Siphoviridae was effective in decreasing population of E. coli K12 and Pseudomonas aeruginosa in a soilcarrot system. Although less effective than a cocktail of phages against these organisms, polyvalent phages were more capable than the phage cocktail of sustaining the diversity of the commensal bacterial community in the system.…”

Section: Discussionmentioning

confidence: 99%

Effect of a bacteriophage T5virus on growth of Shiga toxigenic Escherichia coli and Salmonella strains in individual and mixed cultures

Niu

Liu

Johnson

et al. 2020

Virol J

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A previously isolated a bacteriophage, vB_EcoS_AKFV33 of T5virus, demonstrated great potential in biocontrol of Shiga toxigenic Escherichia coli (STEC) O157. This study further evaluated its potential as a biocontrol agent in broth culture against other important non-O157 serogroups of STEC and Salmonella. AKFV33 was capable of lysing isolates of STEC serogroups O26 (n = 1), O145 (n = 1) and Salmonella enterica serovars (n = 6). In a broth culture microplate system, efficacy of AKFV33 for killing STEC O26:H11, O145:NM and Salmonella was improved (P < 0.05) at a lower multiplicity of infection and sampling time (6-10 h), when STEC O157:H7 was also included in the culture. This phage was able to simultaneously reduce numbers of STEC and Salmonella in mixtures with enhanced activity (P < 0.05) against O157:H7 and O26:H11, offering great promise for control of multiple zoonotic pathogens at both pre and post-harvest.

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Section: Discussionmentioning

confidence: 99%

Effect of a bacteriophage T5virus on growth of Shiga toxigenic Escherichia coli and Salmonella strains in individual and mixed cultures

Niu

Liu

Johnson

et al. 2020

Virol J

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“…Other strategies to reduce antibiotic selective pressure include the use of bacteriophages (a revitalized strategy in recent years) (Viertel et al, 2014;Forti et al, 2018), not only in clinical settings, but also in natural ecosystems (Zhao et al, 2019b), as well as the use of biodegradable antibiotics (Chin et al, 2018) or adsorbents, able to reduce selective pressure on commensal microbiome (De Gunzburg et al, 2015. Besides reducing the chances of selecting ARBs, the use of antibiotics adsorbents may preserve the microbiomes, reducing the risks of infections (Chapman et al, 2016).…”

Section: Controlling Resistance: Local and Global Interventionsmentioning

confidence: 99%

Antibiotic Resistance: Moving From Individual Health Norms to Social Norms in One Health and Global Health

et al. 2020

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Antibiotic resistance is a problem for human health, and consequently, its study had been traditionally focused toward its impact for the success of treating human infections in individual patients (individual health). Nevertheless, antibiotic-resistant bacteria and antibiotic resistance genes are not confined only to the infected patients. It is now generally accepted that the problem goes beyond humans, hospitals, or long-term facility settings and that it should be considered simultaneously in human-connected animals, farms, food, water, and natural ecosystems. In this regard, the health of humans, animals, and local antibiotic-resistance-polluted environments should influence the health of the whole interconnected local ecosystem (One Health). In addition, antibiotic resistance is also a global problem; any resistant microorganism (and its antibiotic resistance genes) could be distributed worldwide. Consequently, antibiotic resistance is a pandemic that requires Global Health solutions. Social norms, imposing individual and group behavior that favor global human health and in accordance with the increasingly collective awareness of the lack of human alienation from nature, will positively influence these solutions. In this regard, the problem of antibiotic resistance should be understood within the framework of socioeconomic and ecological efforts to ensure the sustainability of human development and the associated human-natural ecosystem interactions.

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“…By leveraging the same ecological principle, our laboratory previously showed that growth of a cystic fibrosis pathogen, Pseudomonas aeruginosa , can be inhibited by targeting its cross‐feeding anaerobic partners with antibiotics (Adamowicz et al ., 2018). While we are not the first to consider using multispecies‐targeting cocktails, others have used them with a different goal – to target co‐occurring pathogens (Carson et al ., 2010; Lehman and Donlan, 2015; Oliveira et al ., 2018; Milho et al ., 2019; Zhao et al ., 2019). Additionally, others have explored phage treatment of pathogens in competitive ecological contexts, but limited their analysis to single phage treatments that targeted the focal bacterial species only (Harcombe and Bull, 2005; Brockhurst et al ., 2006; Wang et al ., 2017; Yu et al ., 2017; Testa et al ., 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Descriptions of polyvalent phage have increased over the past five years likely due to directed changes in phage isolation protocols (Hamdi et al ., 2017; Duc et al ., 2020; Li et al ., 2020). In fact, Zhao and colleagues used a soil‐carrot microcosm system to compare the efficacy of a cocktail that included phage targeting two different plant pathogens with a treatment of a single polyvalent phage that infected both pathogens (Zhao et al ., 2019). They found that both treatments effectively limited the growth of both pathogens, but the polyvalent phage treatment disturbed the soil microbiome less than the multipathogen‐targeting cocktail.…”

Section: Discussionmentioning

confidence: 99%

Phage cocktail strategies for the suppression of a pathogen in a cross‐feeding coculture

Fazzino

Anisman

Chacón

et al. 2020

Microbial Biotechnology

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Predicting which combinations (cocktails) of bacteria‐infecting viruses (bacteriophage) will suppress pathogenic bacterial growth is complicated, in part, due to the complex ecological interactions of host bacteria, but important for effective treatment. We found that when hosts cross‐feed (exchange nutrients) with nonhost bacterial species, cocktails that include a bacteriophage infecting the nonhost cross‐feeding partner can be more effective at suppressing pathogenic bacteria than targeting the pathogenic bacterium with multiple bacteriophage species. This is a novel cocktail formulation.

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Comparing polyvalent bacteriophage and bacteriophage cocktails for controlling antibiotic-resistant bacteria in soil-plant system

Cited by 41 publications

References 37 publications

Effect of a bacteriophage T5virus on growth of Shiga toxigenic Escherichia coli and Salmonella strains in individual and mixed cultures

Effect of a bacteriophage T5virus on growth of Shiga toxigenic Escherichia coli and Salmonella strains in individual and mixed cultures

Antibiotic Resistance: Moving From Individual Health Norms to Social Norms in One Health and Global Health

Phage cocktail strategies for the suppression of a pathogen in a cross‐feeding coculture

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