Comparing physical mechanisms for membrane curvature-driven sorting of BAR-domain proteins

Tsai, Feng-Ching; Šimunović, Mijo; Sorre, Benoît; Bertin, Aurélie; Manzi, John; Callan-Jones, Andrew; Bassereau, Patricia

doi:10.1039/d0sm01573c

Cited by 21 publications

(29 citation statements)

References 92 publications

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“…6(a)), C s becomes lower than C p and φ has a broad peak. A similar C s dependence on the tube curvature has been reported in the experiments of the BAR proteins [17,18]. It indicates the anisotropic interaction of the BAR proteins.…”

Section: B Theoretical Resultssupporting

confidence: 85%

“…Since the theory for the isotropic bending energy has been well established, it has been employed even in the analysis for the experiments of the BAR proteins [17,18,32]. In this study, however, we have clarified that the anisotropy of the bending energy largely changes the membrane-protein interactions such as the sensing curvature.…”

Section: Summary and Discussionmentioning

confidence: 86%

“…The curvature-inducing proteins can sense the membrane curvature, i.e., they are concentrated in membranes that have their preferred curvatures. The sensing of curvature-inducing proteins, such as BAR proteins [7,8,13,17,18], dynamin [19], and G-protein coupled receptors [20], has been examined using a tethered vesicle pulled by optical tweezers and a micropipette. They typically bind more onto the membrane tube than the remaining spherical component.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, the effects of the anisotropic spontaneous curvature of proteins have been much less explored. Instead, the bending energy for isotropic spontaneous curvature has been often used for the analysis of BAR proteins [17,18,32]. A few approaches have been examined for the anisotropy of the protein binding.…”

Section: Introductionmentioning

confidence: 99%

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Binding of anisotropic curvature-inducing proteins onto membrane tubes

Noguchi,

Tozzi,

Arroyo

2022

Preprint

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Section: B Theoretical Resultssupporting

confidence: 85%

Section: Summary and Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Binding of anisotropic curvature-inducing proteins onto membrane tubes

Noguchi,

Tozzi,

Arroyo

2022

Preprint

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“…To examine the curvature sensing of protein binding, a tethered vesicle has been most widely employed [14,15,21,41,42,44,[60][61][62][63]. Using optical tweezers and a micropipette, a narrow membrane tube (tether) is extended from a spherical vesicle.…”

Section: Binding Onto Tethered Vesiclementioning

confidence: 99%

Binding of Curvature-Inducing Proteins onto Biomembranes

Noguchi

2022

Preprint

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We review the theoretical analyses and simulations of the interactions between curvatureinducing proteins and biomembranes. Laterally isotropic proteins induce spherical budding, whereas anisotropic proteins, such as Bin/Amphiphysin/Rvs (BAR) superfamily proteins, induce tubulation. Both types of proteins can sense the membrane curvature. We describe the theoretical analyses of various transitions of protein binding accompanied by a change in various properties, such as the number of buds, the radius of membrane tubes, and the nematic order of anisotropic proteins. Moreover, we explain the membrane-mediated interactions and protein assembly. Many types of membrane shape transformations (spontaneous tubulation, formation of polyhedral vesicles, polygonal tubes, periodic bumps, and network structures, etc.) have been demonstrated by coarse-grained simulations. Furthermore, traveling waves and Turing patterns under the coupling of reactiondiffusion dynamics and membrane deformation are described.

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Nonequilibrium Membrane Dynamics Induced by Active Protein Interactions and Chemical Reactions: A Review

Noguchi

2024

ChemSystemsChem

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Biomembranes wrapping cells and organelles are not only the partitions that separate the insides but also dynamic fields for biological functions accompanied by membrane shape changes. In this review, we discuss the spatiotemporal patterns and fluctuations of membranes under nonequilibrium conditions. In particular, we focus on theoretical analyses and simulations. Protein active forces enhance or suppress the membrane fluctuations; the membrane height spectra are deviated from the thermal spectra. Protein binding or unbinding to the membrane is activated or inhibited by other proteins and chemical reactions, such as ATP hydrolysis. Such active binding processes can induce traveling waves, Turing patterns, and membrane morphological changes. They can be represented by the continuum reaction‐diffusion equations and discrete lattice/particle models with state flips. The effects of structural changes in amphiphilic molecules on the molecular‐assembly structures are also discussed.

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Comparing physical mechanisms for membrane curvature-driven sorting of BAR-domain proteins

Abstract: Protein enrichment at specific membrane locations in cells is crucial for many cellular functions. It is well-recognized that the ability of the proteins to sense membrane curvature contributes partly to...

Cited by 21 publications

References 92 publications

Binding of anisotropic curvature-inducing proteins onto membrane tubes

Binding of anisotropic curvature-inducing proteins onto membrane tubes

Binding of Curvature-Inducing Proteins onto Biomembranes

Nonequilibrium Membrane Dynamics Induced by Active Protein Interactions and Chemical Reactions: A Review

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