Comparing Outcomes Between Thiazide Diuretics and Other First-line Antihypertensive Drugs in Long-term Nursing Home Residents

Boockvar, Kenneth S.; Song, Wei; Lee, Sei; Intrator, Orna

doi:10.1016/j.clinthera.2020.02.016

Cited by 4 publications

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diuretics are important for treating many diseases, including hypertension, kidney disorders, and acute heart failure [ 26 , 27 , 28 , 29 ]. However, because chemically synthesized diuretics used in clinical practice have potential side effects [ 30 , 31 , 32 ], there is a need for natural diuretics.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Diuretic Properties of Rice Bean Accessions Using a Mouse Model and Identification of Active Polyphenolic Compounds

Gong,

Zhang,

Yao

et al. 2024

Nutrients

View full text Add to dashboard Cite

Rice bean [Vigna umbellata (Thunb.) Ohwi and Ohashi], an annual legume in the genus Vigna, is a promising crop suitable for cultivation in a changing climate to ensure food security. It is also a medicinal plant widely used in traditional Chinese medicine; however, little is known about the medicinal compounds in rice bean. In this study, we assessed the diuretic effect of rice bean extracts on mice as well as its relationship with the contents of eight secondary metabolites in seeds. Mice gavaged with rice bean extracts from yellow and black seeds had higher urinary output (5.44–5.47 g) and water intake (5.8–6.3 g) values than mice gavaged with rice bean extracts from red seeds. Correlation analyses revealed significant negative correlations between urine output and gallic acid (R = −0.70) and genistein (R = −0.75) concentrations, suggesting that these two polyphenols negatively regulate diuresis. There were no obvious relationships between mice diuresis-related indices (urine output, water intake, and weight loss) and rutin or catechin contents, although the concentrations of both of these polyphenols in rice bean seeds were higher than the concentrations of the other six secondary metabolites. Our study findings may be useful for future research on the diuretic effects of rice bean, but they should be confirmed on the basis of systematic medical trials.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of the Diuretic Properties of Rice Bean Accessions Using a Mouse Model and Identification of Active Polyphenolic Compounds

Gong,

Zhang,

Yao

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

Patient Safety

Jhaveri

2020

Clinical Therapeutics

View full text Add to dashboard Cite

Last year, I celebrated 20 years in practice posteresidency training. Some would consider me late in my "mid-career" phase given my age, while others would argue that my appointment of professor marks me as early "late career." Regardless of the semantics, I would say one of the biggest changes that I have observed in our health care system over the past 20 years has been an increased focus on patient safety. Using the search phrase patient safety in PubMed, the resulting published articles have exploded, from just 71 in 1999 to almost 5000 in 2019. 1 I would like to share a story from my field, infectious diseases, that I think illustrates how our practice has changed to reflect this increased focus on patient safety.During my residency training, the prevailing thinking in managing osteomyelitis in children was to use IV antibiotics, administered via a peripherally inserted central catheter (PICC), as the primary means of treatment. 2 The duration of therapy was 4e6 weeks, and only some practitioners were using oral antibiotics in the later stages of therapy in patients who had improved very quickly. 3 When I became a fellow at UCLA, my mentor, Paul Krogstad, taught me to be more aggressive in transitioning to oral therapy once the most severe phase of the infection was over. We used clinical improvement, along with normalization of C-reactive protein, as the primary indicators of the appropriate time to switch to oral antibiotics. Despite my individual training, for many years the field was still rooted in the use of long-term IV therapy as the "safer" option. Many providers valued the higher serum drug levels that came with IV therapy and the associated increased concentration gradient to drive more antibiotic into the infected bone. I spent many a conversation during my early faculty years advocating for an early switch to oral agents, citing the decreased cost, increased convenience of oral dosing, and equivalent long-term outcomes. Nonetheless, those practitioners transitioning to oral therapy still seemed to be in the minority.In 2009, an article was published that served as a catalyst to change opinion. Zaoutis et al. 4 used a large pediatrics administrative database to compare outcomes in children with osteomyelitis treated with IV only or transitioned to oral antibiotics at any point in their therapy. They demonstrated that children who were transitioned to oral therapy had outcomes similar to those treated with IV antibiotics. They also demonstrated that children receiving IV therapy had increased rates of adverse events and catheter-related complications compared with those in children treated with oral antibiotics. Those results seem obvious now, but the article served to change the conversation about which treatment option was "safer" for patients. Since that time, our approach to the treatment of osteomyelitis has completely changed, such that transition to oral therapy is the standard of care and a provider needs to justify a plan for long-term IV antibiotic therapy via PICC line. A similar moveme...

show abstract

Optimizing Medication Use in Older Adults

Hung

Chow

2020

Clinical Therapeutics

View full text Add to dashboard Cite

Comparing Outcomes Between Thiazide Diuretics and Other First-line Antihypertensive Drugs in Long-term Nursing Home Residents

Cited by 4 publications

References 33 publications

Assessment of the Diuretic Properties of Rice Bean Accessions Using a Mouse Model and Identification of Active Polyphenolic Compounds

Assessment of the Diuretic Properties of Rice Bean Accessions Using a Mouse Model and Identification of Active Polyphenolic Compounds

Patient Safety

Optimizing Medication Use in Older Adults

Contact Info

Product

Resources

About