Comparing Objective Perimetry, Matrix Perimetry, and Regional Retinal Thickness in Mild Diabetic Macular Edema

Bahadur, Bhim; Maddess, Ted; Carle, Corinne F.; Rohan, Emilie; Kleef, Josh P. van; Barry, Richard C.; Essex, Rohan W; Nolan, Christopher; Sabeti, Faran

doi:10.1167/tvst.10.13.32

Cited by 15 publications

(32 citation statements)

References 35 publications

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“…The effect pupillary autonomic neuropathy is relatively minor because frequently the diagnostic power is carried by the few most deviating points in a field, as we have shown before [ 17 – 19 ], and in Fig. 2 .…”

Section: Discussionmentioning

confidence: 58%

“…Classification by eye, where a fellow eye could be worse, produced AUCs about 2% higher. Aside from our mfPOP studies of diabetic eye disease [ 17 – 19 ], other functional measures indicate that the retinal neuropathy can precede classical diabetic retinopathy [ 28 , 31 – 35 ]. Here we found mfPOP discriminated patients with and without DR, the Yellow Wide protocol achieving AUCs between 79.0 and 85.9% (Table 5 ).…”

Section: Discussionmentioning

confidence: 99%

“…At the request of a reviewer we examined the correlation between eyes of the regional data. In fact larger and smaller than normal sensitivities or delays can be seen frequently in the same retina [ 19 ]. We calculated the correlation between the 1672 to 2200 field points for each of the two eyes.…”

Section: Discussionmentioning

confidence: 99%

“…Another report on 6 studies of 96 normal subjects showed that the signal to noise ratios for the clustered-volleys method was between 35 and 57% larger than methods like those here ( p < 0.001 in 5/6 studies) (Carle et al Clustered volleys stimulus presentation for multifocal pupil perimetry, In revision). Using those stimuli we have compared mfPOP with structural data from optical coherence tomography and macular perimetry in T2D patients with and without mild macular oedema [ 19 ], and have shown that mfPOP functional change over time correlates well with structural change (Sabeti et al Objective Perimetry identifies functional progression and recovery in mild diabetic macular oedema, In revision).…”

Section: Discussionmentioning

confidence: 99%

“…We have shown mfPOP to be clinically useful in early [ 12 , 13 ] and later stage [ 14 – 16 ] age-related macular degeneration (AMD). We have also shown that mfPOP is able to identify localised visual field dysfunction in type 2 diabetes (T2D) subjects prior to the development of clinically detectable retinal vasculopathy [ 17 , 18 ] and early-stage diabetic macular oedema [ 19 ]. Diabetic changes to the visual fields are similar in multifocal visual evoked potentials (mfVEPs) and mfPOP when tested in the same subjects [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Multifocal pupillographic objective perimetry for assessment of early diabetic retinopathy and generalised diabetes-related tissue injury in persons with type 1 diabetes

et al. 2022

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Background To examine the potential utility of five multifocal pupillographic objective perimetry (mfPOP) protocols, in the assessment of early diabetic retinopathy (DR) and generalised diabetes-related tissue injury in subjects with type 1 diabetes (T1D). Methods Twenty-five T1D subjects (age 41.8 ± 12.1 (SD) years, 13 male) with either no DR (n = 13) or non-proliferative DR (n = 12), and 23 age and gender-matched control subjects (age 39.7 ± 12.9 years, 9 male) were examined by mfPOP using five different stimulus methods differing in visual field eccentricity (central 30° and 60°), and colour (blue, yellow or green test-stimuli presented on, respectively, a blue, yellow or red background), each assessing 44 test-locations per eye. In the T1D subjects, we assessed 16 metabolic status and diabetes complications variables. These were summarised as three principal component analysis (PCA) factors. DR severity was assessed using Early Treatment of Diabetic Retinopathy Study (ETDRS) scores. Area under the curve (AUC) from receiver operator characteristic analyses quantified the diagnostic power of mfPOP response sensitivity and delay deviations for differentiating: (i) T1D subjects from control subjects, (ii) T1D subjects according to three levels of the identified PCA-factors from control subjects, and (iii) TID subjects with from those without non-proliferative DR. Results The two largest PCA-factors describing the T1D subjects were associated with metabolic variables (e.g. body mass index, HbA1c), and tissue-injury variables (e.g. serum creatinine, vibration perception). Linear models showed that mfPOP per-region response delays were more strongly associated than sensitivities with the metabolic PCA-factor and ETDRS scores. Combined mfPOP amplitude and delay measures produced AUCs of 90.4 ± 8.9% (mean ± SE) for discriminating T1D subjects with DR from control subjects, and T1D subjects with DR from those without of 85.9 ± 8.8%. The yellow and green stimuli performed better than blue on most measures. Conclusions/interpretation In T1D subjects, mfPOP testing was able to identify localised visual field functional abnormalities (retinal/neural reflex) in the absence or presence of mild DR. mfPOP responses were also associated with T1D metabolic status, but less so with early stages of non-ophthalmic diabetes complications.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multifocal pupillographic objective perimetry for assessment of early diabetic retinopathy and generalised diabetes-related tissue injury in persons with type 1 diabetes

et al. 2022

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Rapid, non-contact multifocal visual assessment in multiple sclerosis

et al. 2022

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Objective Previous work on temporally sparse multifocal methods suggests that the results are correlated with disability and progression in people with multiple sclerosis (PwMS). Here, we assess the diagnostic power of three cortically mediated sparse multifocal pupillographic objective perimetry (mfPOP) methods that quantified response-delay and light-sensitivity at up to 44 regions of both visual fields concurrently. Methods One high-spatial-resolution mfPOP method, P129, and two rapid medium-resolution methods, W12 and W20, were tested on 44 PwMS and controls. W12 and W20 took 82 s to test both visual fields concurrently, providing response delay and sensitivity at each field location, while P129 took 7 min. Diagnostic power was assessed using areas under the receiver operating characteristic (AUROC) curves and effect-size (Hedges’ g). Linear models examined significance. Concurrent testing of both eyes permitted assessment of between-eye asymmetries. Results Per-region response delays and asymmetries achieved AUROCs of 86.6% ± 4.72% (mean ± SE) in relapsing–remitting MS, and 96.5% ± 2.30% in progressive MS. Performance increased with increasing disability scores, with even moderate EDSS 2 to 4.5 PwMS producing AUROCs of 82.1 to 89.8%, Hedge’s g values up to 2.06, and p = 4.0e − 13. All tests performed well regardless of any history of optic neuritis. W12 and W20 performed as well or better than P129. Conclusion Overall, the 82-s tests (W12 and W20) performed better than P129. The results suggest that mfPOP assesses a correlate of disease severity rather than a history of inflammation, and that it may be useful in the clinical management of PwMS.

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Prevalence and severity of diabetic retinopathy at first presentation to vitreoretinal services in Bhutan: a 3-year national study

et al. 2023

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Comparing Objective Perimetry, Matrix Perimetry, and Regional Retinal Thickness in Mild Diabetic Macular Edema

Cited by 15 publications

References 35 publications

Multifocal pupillographic objective perimetry for assessment of early diabetic retinopathy and generalised diabetes-related tissue injury in persons with type 1 diabetes

Multifocal pupillographic objective perimetry for assessment of early diabetic retinopathy and generalised diabetes-related tissue injury in persons with type 1 diabetes

Rapid, non-contact multifocal visual assessment in multiple sclerosis

Prevalence and severity of diabetic retinopathy at first presentation to vitreoretinal services in Bhutan: a 3-year national study

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