Comparing Medial Temporal Atrophy Between Early-Onset Semantic
Dementia and Early-Onset Alzheimer's Disease Using Voxel-Based Morphometry:
A Multicenter MRI Study

Kobayashi, Ryota; Hayashi, Hiroshi; Kawakatsu, Shinobu; Shibuya, Yuzuru; Morioka, Daichi; Ohba, Makoto; Yoshioka, Masumi; Sakamoto, Kazutaka; Kanoto, Masafumi; Otani, Koichi

doi:10.2174/1567205019666220820145429

Cited by 3 publications

(1 citation statement)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On MRI, image-supported svPPA has inferolateral ATL involvement distinguishable from more prominent hippocampal and parietal lobe atrophy in AD [ 7 ]. svPPA has more severe and asymmetrical atrophy in temporal structures than AD [ 43 ]. FDG-PET imaging can confirm focal predominant hypometabolism localized to the ATLs as in this patient ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Distinguishing Semantic Variant Primary Progressive Aphasia from Alzheimer’s Disease

Mendez

Nasir

2023

ADR

View full text Add to dashboard Cite

The differentiation of semantic variant primary progressive aphasia from dementia and Alzheimer’s disease can be difficult, particularly when the semantic anomia is pronounced. This report describes a patient who presented with complaints of memory loss and proved to have prominent semantic loss of all types of nouns, common and proper, concrete and abstract, yet continued to live independently and maintain his activities of daily living. The evaluation was consistent for semantic variant primary progressive aphasia with degradation of semantic knowledge and focal anterior temporal atrophy and hypometabolism. This report summarizes the literature and discusses the differential diagnosis of this disorder from Alzheimer’s disease and related dementias.

show abstract

Section: Discussionmentioning

confidence: 99%

Distinguishing Semantic Variant Primary Progressive Aphasia from Alzheimer’s Disease

Mendez

Nasir

2023

ADR

View full text Add to dashboard Cite

show abstract

Temporo‐frontoparietal hypoconnectivity as a biomarker for isolated language impairment in mild cognitive impairment: A cross‐cohort comparison

Huang,

Hu,

Cui

et al. 2024

Alzheimer's & Dementia

View full text Add to dashboard Cite

INTRODUCTIONWhether brain functional connectivity (FC) is consistently disrupted in individuals with mild cognitive impairment (MCI) with isolated language impairment (ilMCI), and its potential to differentiate between MCI subtypes remains uncertain.METHODSCross‐sectional data from 404 participants in two cohorts (the Chinese Preclinical Alzheimer's Disease Study and the Alzheimer's Disease Neuroimaging Initiative) were analyzed, including neuropsychological tests, resting‐state functional magnetic resonance imaging (fMRI), cerebral amyloid positivity, and apolipoprotein E (APOE) status.RESULTSTemporo‐frontoparietal FC, particularly between the bilateral superior temporal pole and the left inferior frontal/supramarginal gyri, was consistently decreased in ilMCI compared to amnestic MCI (aMCI) and normal controls, which was correlated with semantic impairment. Using mean temporo‐frontoparietal FC as a classifier could improve accuracy in identifying ilMCI subgroups with positive cerebral amyloid deposition and APOE risk alleles.DISCUSSIONTemporal‐frontoparietal hypoconnectivity was observed in individuals with ilMCI, which may reflect semantic impairment and serve as a valuable biomarker to indicate potential mechanisms of underlying neuropathology.Highlights Temporo‐frontoparietal hypoconnectivity was observed in impaired language mild cognitive impairment (ilMCI). Temporo‐frontoparietal hypoconnectivity may reflect semantic impairment. Temporo‐frontoparietal functional connectivity can classify ilMCI subtypes.

show abstract

In vivo [18F]THK-5351 imaging detected reactive astrogliosis in argyrophilic grain disease with comorbid pathology: A clinicopathological study

Kobayashi¹,

Nakamura²,

Naganuma³

et al. 2023

Journal of Neuropathology &Amp; Experimental Neurology

View full text Add to dashboard Cite

Quantification of in vivo reactive astrogliosis, which represents neural inflammation and remodeling in the brain, is an emerging methodology for the evaluation of patients with neurodegenerative diseases. [18F]THK-5351 is a positron emission tomography (PET) tracer for monoamine oxidase B (MAO-B), a molecular marker of reactive astrogliosis. We performed in vivo [18F]THK-5351 PET in a patient who at autopsy was found to have argyrophilic grain disease (AGD) with comorbid pathology to visualize reactive astrogliosis for the first time. We aimed to validate an imaging-pathology correlation using [18F]THK-5351 PET and the autopsy brain. The patient, a 78-year-old man, was pathologically diagnosed with AGD combined with limbic-predominant age-related transactive response DNA-binding protein of 43 kDa encephalopathy and Lewy body disease without Alzheimer disease-related neuropathological changes. Reactive astrogliosis in the postmortem brain was abundant in the inferior temporal gyrus, insular gyrus, entorhinal cortex, and ambient gyrus where premortem [18F]THK-5351 signals were high. We found a proportional correlation between the amount of reactive astrogliosis in the postmortem brain and the in vivo [18F]THK-5351 standardized uptake value ratio (r = 0.8535, p = 0.0004). These results indicated that reactive astrogliosis in AGD with comorbid pathology could be identified and quantified by in vivo MAO-B imaging.

show abstract

Comparing Medial Temporal Atrophy Between Early-Onset Semantic Dementia and Early-Onset Alzheimer's Disease Using Voxel-Based Morphometry: A Multicenter MRI Study

Cited by 3 publications

References 45 publications

Distinguishing Semantic Variant Primary Progressive Aphasia from Alzheimer’s Disease

Distinguishing Semantic Variant Primary Progressive Aphasia from Alzheimer’s Disease

Temporo‐frontoparietal hypoconnectivity as a biomarker for isolated language impairment in mild cognitive impairment: A cross‐cohort comparison

In vivo [18F]THK-5351 imaging detected reactive astrogliosis in argyrophilic grain disease with comorbid pathology: A clinicopathological study

Contact Info

Product

Resources

About