Comparing isolated soy protein with flaxseed oil vs isolated soy protein with corn oil and wheat flour with corn oil consumption on muscle catabolism, liver function, blood lipid, and sugar in burn patients: a randomized clinical trial

Babajafari, Siavash; Hojhabrimanesh, Abdollah; Sohrabi, Zahra; Ayaz, Mehdi; Noorafshan, Ali; Akrami, Abbas

doi:10.1186/s13063-018-2693-5

Cited by 8 publications

(3 citation statements)

References 67 publications

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“…Especially in burn patients, gastrointestinal congestion leads to impaired functions of digestion and absorption, which further augments the concern of protein nutrition increasing kidney burden [ 34 ]. However, results from a clinical trial indicate that isolated soybean protein with flaxseed oil or corn oil nutritional support has no significant effect on increasing the kidney burden [ 35 ]. In the current study, we observed slightly increased UA levels after burn injury on days 3, 7, and 14, which were further elevated on days 7 and 14 after blended protein administration, but with no significant difference observed between the three groups ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Effect of blended protein nutritional support on reducing burn-induced inflammation and organ injury

Zhang

Wang

et al. 2022

Nutr Res Pract

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BACKGROUND/OBJECTIVES Previous studies have reported that protein supplementation contributes to the attenuation of inflammation. Serious trauma such as burn injury usually results in the excessive release of inflammatory factors and organs dysfunction. However, a few reports continued to focus on the function of protein ingestion in regulating burn-induced inflammation and organ dysfunction. MATERIALS/METHODS This study established the rat model of 30% total body surface area burn injury, and evaluated the function of blended protein (mixture of whey and soybean proteins). Blood routine examination, inflammatory factors, blood biochemistry, and immunohistochemical assays were employed to analyze the samples from different treatment groups. RESULTS Our results indicated a decrease in the numbers of white blood cells, monocytes, and neutrophils in the burn injury group administered with the blended protein nutritional support (Burn+BP), as compared to the burn injury group administered normal saline supplementation (Burn+S). Expressions of the pro-inflammatory factors (tumor necrosis factor-α and interleukin-6 [IL-6]) and chemokines (macrophage chemoattractant protein-1, regulated upon activation normal T cell expressed and secreted factor, and C-C motif chemokine 11) were dramatically decreased, whereas anti-inflammatory factors (IL-4, IL-10, and IL-13) were significantly increased in the Burn+BP group. Kidney function related markers blood urea nitrogen and serum creatinine, and the liver function related markers alanine transaminase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase were remarkably reduced, whereas albumin levels were elevated in the Burn+BP group as compared to levels obtained in the Burn+S group. Furthermore, inflammatory cells infiltration of the kidney and liver was also attenuated after burn injury administered with blended protein supplementation. CONCLUSIONS In summary, nutritional support with blended proteins dramatically attenuates the burn-induced inflammatory reaction and protects organ functions. We believe this is a new insight into a potential therapeutic strategy for nutritional support of burn patients.

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Section: Resultsmentioning

confidence: 99%

Effect of blended protein nutritional support on reducing burn-induced inflammation and organ injury

Zhang

Wang

et al. 2022

Nutr Res Pract

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“…Protein supplementation significantly increased lean body mass, but not muscle strength in burn patients 28 . Isolated soy protein and flaxseed oil also reduced muscle catabolism and increased body weight in burn patients 29 . Dietary supplementation with inulin was also observed to improve weight loss and skeletal muscle atrophy in burned rats, probably due to the modulatory effect of inulin on the gut microbiota, which thereby improved metabolism.…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation with inulin improves burn-induced skeletal muscle atrophy by regulating gut microbiota disorders

Gao,

Zhao,

Leng

et al. 2024

Sci Rep

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Inulin, as a prebiotic, could modulate the gut microbiota. Burn injury leads to gut microbiota disorders and skeletal muscle catabolism. Therefore, whether inulin can improve burn-induced muscle atrophy by regulating microbiota disorders remains unknown. This study aimed to clarify that inulin intake alleviates gut microbiota disorders and skeletal muscle atrophy in burned rats. Rats were divided into the sham group, burn group, prebiotic inulin intervention group, and pseudo-aseptic validation group. A 30% total body surface area (TBSA) third-degree burn wound on dorsal skin was evaluated in all groups except the sham group. Animals in the intervention group received 7 g/L inulin. Animals in the validation group received antibiotic cocktail and inulin treatment. In our study inulin intervention could significantly alleviate the burn-induced skeletal muscle mass decrease and skeletal myoblast cell apoptosis. Inulin intake increased the abundances of Firmicutes and Actinobacteria but decreased the abundance of Proteobacteria. The biosynthesis of amino acids was the most meaningful metabolic pathway distinguishing the inulin intervention group from the burn group, and further mechanistic studies have shown that inulin can promote the phosphorylation of the myogenesis-related proteins PI3K, AKT and P70S6K and activate PI3K/AKT signaling for protein synthesis. In conclusion, inulin alleviated burn induced muscle atrophy through PI3K/AKT signaling and regulated gut microbiota dysbiosis.

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“…La caída en los niveles de glutamina aumenta el riesgo de infección, la permeabilidad intestinal y la mortalidad, por lo que es importante valorar semanalmente estos niveles (2,11). El soporte nutricional con proteína de soya y aceite de linaza favorece el resultado final del paciente, ya que contiene cantidades elevadas de aminoácidos y omega-3, los cuales ayudan a la desinflamación y la cicatrización de las heridas (13).…”

Section: Requerimientos Específicosunclassified

Manejo general nutricional del paciente gran quemado adulto y sus complicaciones

Mora

Vargas

2023

Rev.méd.sinerg.

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Las quemaduras se dan cuando los tejidos blandos entran en contacto con una fuente de calor o energía, varían en su presentación y severidad. La morbilidad y la mortalidad se incrementan de acuerdo a la cantidad de superficie corporal quemada, mientras que la localización de las lesiones, la energía, y el tiempo de exposición contribuyen a la severidad. Los pacientes grandes quemados presentan alteraciones metabólicas muy significativas que repercuten negativamente en la morbilidad, la mortalidad y el tiempo de recuperación. El soporte nutricional aporta los nutrientes y los agentes terapéuticos necesarios para mantener el estado nutricional. El objetivo principal del soporte nutricional es aportar las distintas demandas corporales que son consecuencia del hipercatabolismo. El inicio del soporte nutricional temprano en los pacientes quemados, que tengan criterio para este, representa uno de los factores más efectivos en la regulación metabólica dada por las lesiones térmicas, manifestándose como una disminución de la respuesta catabólica y actualmente considerados como piedra angular en el manejo básico de los grandes quemados. Existen tres distintas vías de soporte nutricional, la oral, enteral o parenteral. La vía oral es la recomendada, si el paciente puede consumir el 60% de los requerimientos calóricos. Si el consumo es inadecuado, se debe considerar la nutrición enteral o parenteral. El paciente gran quemado es de manejo multidisciplinario. Las quemaduras que afectan más de 20% de la superficie corporal afectada requieren nutrición enteral temprana, ya que mejora la supervivencia y disminuye la estancia hospitalaria, así como las complicaciones tanto gastrointestinales como generales.

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Comparing isolated soy protein with flaxseed oil vs isolated soy protein with corn oil and wheat flour with corn oil consumption on muscle catabolism, liver function, blood lipid, and sugar in burn patients: a randomized clinical trial

Cited by 8 publications

References 67 publications

Effect of blended protein nutritional support on reducing burn-induced inflammation and organ injury

Effect of blended protein nutritional support on reducing burn-induced inflammation and organ injury

Dietary supplementation with inulin improves burn-induced skeletal muscle atrophy by regulating gut microbiota disorders

Manejo general nutricional del paciente gran quemado adulto y sus complicaciones

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