Comparing indications for cardiovascular admissions into a Nigerian and an Israeli Hospital

Ukpabi, Ogba J; Uwanurochi, Kelechukwu

doi:10.4103/aam.aam_30_16

Cited by 9 publications

(11 citation statements)

References 14 publications

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“…Work by Wachukwu et al found a renal disease prevalence of 15.4% in tandem with the renal disease prevalence found in this study [11]. Other works in tertiary centres in neighbouring south-east, Nigeria reported cardiovascular diseases as leading causes of medical ward admissions [9,12]. These further buttresses the increasing burden of cardiovascular diseases and other NCDs in the developing nations which is related to changing lifestyles and in consonant with the epidemiologic transition concept in developing nations of the world.…”

Section: Discussionsupporting

confidence: 77%

Non Communicable Disease Admissions in Developing Country as Experienced from the Medical Ward of a Tertiary Centre in Nigeria

Akubudike¹,

Eze²

2018

CAJPH

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Non-Communicable Diseases (NCDs) are chronic medical conditions that are non-infectious. NCDs which include a cluster of illnesses (Diabetes mellitus, Cancers, Chronic respiratory diseases, cardiovascular disease and musculoskeletal disorders) are increasing worldwide due to changing lifestyles and socio-economic status with significant contribution to the global disease burden. It is projected that by 2020, the largest increase in NCD deaths will occur in Africa which currently has a heavy infectious diseases burden. NCDs usually affect adults who are economically productive and bear enormous social responsibilities. The aim of this study is to determine the pattern of non-communicable diseases in the medical wards of the University of Port Harcourt Teaching Hospital (UPTH). It was a retrospective and hospital based study. The admission and discharge registers of the medical wards of UPTH from January 2013 to December 2016 were reviewed and NCD admissions extracted. There were 1096 cases of various NCDs constituting 57.7% of total medical ward admissions of 1898. The male to female ratio was 1:1.2 with a mean age of 54.40±21 years. Subjects ≥50 years of age accounted for 60.5% of total admissions. Diseases of the cardiovascular, endocrine and renal systems were found to be the most prevalent accounting for 46.5%, 18.8% and 12.4% respectively of the NCDs in this study. Hypertension and hypertension-related complications, diabetes mellitus, and chronic renal failure are major and important contributor to NCD admissions in the medical wards of UPTH. Early detection, appropriate management as well as patient education will play significant role in reducing its morbidity and mortality.

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Section: Discussionsupporting

confidence: 77%

Non Communicable Disease Admissions in Developing Country as Experienced from the Medical Ward of a Tertiary Centre in Nigeria

Akubudike¹,

Eze²

2018

CAJPH

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“…According to reports, almost all unexpected deaths of medical origin in Nigeria are due to CVD [2,3]. As reported by Ukpabi & Uwanurochi [2], the prevalence of CVD in Northern Nigeria was 8% in 1970. Between 1993 and 2003, CVD prevalence was reported to be at an average of 17.6% in the Country and 20.1% in 2017 in South-East Nigeria [3].…”

Section: Introductionmentioning

confidence: 97%

“…In developing countries like Nigeria and Tanzania, mortality due to CVD is expected to rise above 18 million by 2020 with deaths affecting age bracket of 15 -59 [3]. According to reports, almost all unexpected deaths of medical origin in Nigeria are due to CVD [2,3]. As reported by Ukpabi & Uwanurochi [2], the prevalence of CVD in Northern Nigeria was 8% in 1970.…”

Section: Introductionmentioning

confidence: 99%

“…Dyslipidaemia, type 2 diabetes mellitus, cardiovascular disease (CVD) and other forms of metabolic disorders are global health problems associated with overweight and obesity that promote biochemical and neurohormonal processes which eventually culminate in a nonproductive life of existence [1,2,3]. In developing countries like Nigeria and Tanzania, mortality due to CVD is expected to rise above 18 million by 2020 with deaths affecting age bracket of 15 -59 [3].…”

Section: Introductionmentioning

confidence: 99%

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A Study of Correlation of Anthropometric Data with Atherogenic Indices of Students of Rivers State University, Port Harcourt, Nigeria

Elekima

Inokon

2019

AJRIMPS

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Aim: The aim of the study was to correlate anthropometric data with atherogenic indices of students in Rivers State University, Port Harcourt as a means of assessing their cardiovascular health. Study Design: A pilot study was carried out in Rivers State University, Port Harcourt in Rivers State, Nigeria. The study was conducted within a period of 4 months (June – September, 2018). A total of 82 students were selected from the recruitment process after consenting to participate in the study. Atherogenic indices (after determination of lipid parameters values) and anthropometric measurements were done at the Department of Medical Laboratory Science, Rivers State University, Port Harcourt, Nigeria. Methodology: Five millitres (5mls) of fasting blood samples were collected into lithium heparin bottles and spun at 3500 rpm for 5 minutes to obtain plasma. Total cholesterol (TC) and Triglyceride (TG) were assayed based on enzymatic methods. High density lipoprotein (HDL) was assayed using precipitation and enzymatic method while low density lipoprotein (LDL) was calculated using Friedewald equation. After determination of lipid parameters, atherogenic indices were computed as ratios of these lipid parameters. Anthropometric measurements were collected using stadiometer, non-stretchable tape and weighing scale. Results: Significant increases were seen in both atherogenic indices and anthropometric data of obese (OBS) and overweight (OVW) students compared to ideal weight (NOM) students. Correlation of anthropometric data with atherogenic indices in obese (OBS) students indicated significant positive correlation between WC with NHDL and CRI-2 as well as between WHR with NHDL, AC, CRI-1 and CRI-2. Conclusion: Obesity is a strong factor among students that induces atherogenic hyperlipoproteinaemia and thus, CVD risks. Also, WHR and WC correlates strongly with atherogenic indices such as NHDL, AC, CRI-1 and CRI-2 and therefore, were seen as better and sensitive anthropometric parameters for predicting cardiovascular risks compared to WHtR and BMI.

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“…Cardiovascular disease (CVD) is a class of diseases that involve the heart and blood vessels [14,15]. Diabetic complications such as CVD areone of the leading cause of morbidity and mortality for some population in developed and developing countries of the world with hypertension and heart failure having the highest admissions [16]. Therefore, having a better understanding of the antioxidant supplementations and cardiovascular disease could pave way for better management of CVD and other health conditions.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antioxidants Supplementation on Renal, Hepatic and Cardiac Function Markers in Alloxan Induced Diabetes Mellitus Wister Rats

Ben-Chioma

Sheudeen

Dornu

et al. 2020

JOCAMR

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Aim: To evaluate antioxidants supplementation (selenium and vitamin E) on renal, hepatic and cardiac function markers in alloxan induced diabetes mellitus in Wister rats. Study Design: Rats were randomly assigned into 5 groups with each group consisting of 5 rats. The treatment pattern involved the induction of hyperglycaemia in the rats followed by oral administration of selenium and vitamin E supplements singularly and in combination. The groups are as follow: Group A: Alloxan induced diabetic Rats treated with selenium (0.02 mg/kg) for 35 days. Group B: Alloxan induced diabetic Rats treated with Vitamin E (70.0 mg/kg) for 35 days. Group C: Alloxan induced diabetic Ratstreated with both Selenium and Vitamin E (0.02 mg/kg + 70.0 mg/kg) for a period of 35 days. Group D: Alloxan induced diabetic Rats without any treatment (Positive control) for 35 days. Group E: Rats in this group were fed normally for 35 days without induction and treatment (Negative control). Place and Duration of the Study Area: The study was carried out in the Department of Medical Laboratory Science, Rivers State University, Port Harcourt, Nigeria over a period of 9 months (January, 2019 – September, 2019). Methodology: After the inducement of hyperglycaemia in the rats (Group A – D) with a single dose intraperitoneal (IP) injection of 140mg/kg body weight of alloxan hydrate, treatment with the antioxidants (selenium and Vitamin E) was performed for 35 days. At the end of 35 days, the animals were allowed to fast for 18 hours and sacrificed. Plasma specimen collected was used for the assay of Na+, K+, HCO3, urea, creatinine, cardiac troponin I, LDH, AST, ALT, ALP, bilirubin, protein, albumin globulin and MDA while renal, hepatic and cardiac tissues collected were used for histological investigations. Results: Significantly lower values were seen in Na+, K+, HCO3 and conjugated bilirubin in the diabetic rats without antioxidants supplementation (group D) when compared to diabetic rats with antioxidants supplementation of selenium and vitamin E (group A, B & C) and non-diabetic control group (group E). There were no significant differences seen when Group A, B, C and E were compared among one another. Also, significantly higher values were seen in AST, ALT, ALP, Unconjugated bilirubin, urea, creatinine, cardiac troponin I and MDA in the diabetic rats without antioxidants supplementation (group D) when compared with diabetic rats treated with antioxidants supplements of selenium and vitamin E (group A, B & C) and non-diabetic control group (group E). However, no significant differences were seen in LDH, total protein, albumin, globulin and total bilirubin at P=.05. Histological findings in the kidneys, liver and cardiac tissues of the rats treated with antioxidants supplement showed recovery tendencies compared to diabetic rats without antioxidant supplementation. Conclusion: Results obtained suggest that the use of selenium or vitamin E singularly or in combination has ameliorative effect on cardiac, renal and hepatic function markers in alloxan-induced diabetic rats. However, the combination of selenium and vitamin E had no synergistic advantage over the use of selenium or vitamin E alone.

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Comparing indications for cardiovascular admissions into a Nigerian and an Israeli Hospital

Cited by 9 publications

References 14 publications

Non Communicable Disease Admissions in Developing Country as Experienced from the Medical Ward of a Tertiary Centre in Nigeria

Non Communicable Disease Admissions in Developing Country as Experienced from the Medical Ward of a Tertiary Centre in Nigeria

A Study of Correlation of Anthropometric Data with Atherogenic Indices of Students of Rivers State University, Port Harcourt, Nigeria

Evaluation of Antioxidants Supplementation on Renal, Hepatic and Cardiac Function Markers in Alloxan Induced Diabetes Mellitus Wister Rats

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