Comparing health-related quality of life in modified Rankin Scale grades: 15D results from 323 patients with brain arteriovenous malformation and population controls

Abstract

Background We wanted to understand how patients with different modified Rankin Scale (mRS) grades differ regarding their health-related quality of life (HRQoL) and how this affects the interpretation and dichotomization of the grade. Methods In 2016, all adult patients in our brain arteriovenous malformation (AVM) database (n = 432) were asked to fill in mailed letters including a questionnaire about self-sufficiency and lifestyle and the 15D HRQoL questionnaire. The follow-up mRS was defined in 2016 using the electronic patient registry and the questionnaire data. The 15D profiles of each mRS grade were compared to those of the general population and to each other, using ANCOVA with age and sex standardization. Results Patients in mRS 0 (mean 15D score = 0.954 ± 0.060) had significantly better HRQoL than the general population (mean = 0.927 ± 0.028), p < 0.0001, whereas patients in mRS 1–4 had worse HRQoL than the general population, p < 0.0001. Patients in mRS 1 (mean = 0.844 ± 0.100) and mRS 2 (mean = 0.838 ± 0.107) had a similar HRQoL. In the recently published AVM research, the most commonly used cut points for mRS dichotomization were between mRS 1 and 2 and between mRS 2 and 3. Conclusions Using 15D, we were able to find significant differences in the HRQoL between mRS 0 and mRS 1 AVM patients, against the recent findings on stroke patients using EQ-5D in their analyses. Although the dichotomization cut point is commonly set between mRS 1 and 2, patients in these grades had a similar HRQoL and a decreased ability to continue their premorbid lifestyle, in contrast to patients in mRS 0.

Validation of β- Patient Self-Sufficiency Assessment Scale - the Results of a Pilot Study

“…Although the use of new technologies is certainly revolutionary in this direction, the study also demonstrated certain limits that these technologies still have. In the Finnish studies of the authors Pohjola et al in 2021 [13] tested the modified Rankin Scale in patients with cerebral vascular malformations and assessed the quality of life and health of these patients and compared the results with the general population. The modified Rankin Scale showed significantly better results of the followed patients than the general population, which was measured by the original Rankin Scale.…”

Study on the intervention effect of SMG health management in patients with ischemic stroke

“…The rehabilitation phase after ischemic stroke has been dedicated to the recovery of neurological function. The NIHSS [6] and mRS [23] are internationally recognized scales evaluating neurological outcomes and outcomes before and after treatment in stroke patients. In this study, after 3 months of nursing intervention of brain and heart health managers combined with "SMG" health management mode, patients' NIHSS score and mRS score improved significantly compared with routine care intervention.…”

“…Impaired neurological function was positively correlated with the score. Patient disability was assessed using a modified Rankin scale (mRS) [1,23], with a scale reliability and validity of 0.740, a total score of 0 to 6, and 0 indicates no neurological dysfunction, and 6 indicates death.…”