Comparing gene expression profiles of Kashin-Beck and Keshan diseases occurring within the same endemic areas of China

Xi, Wang; Wang, Shuang; He, Shulan; Zhang, Feng; Tan, Wenfeng; Lei, Yanxia; Yu, Hanjie; Li, Zheng; Ning, Yujie; Xiang, Youzhang; Guo, Xiong

doi:10.1007/s11427-013-4495-z

Cited by 17 publications

(7 citation statements)

References 25 publications

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“…A number of hormones and cytokines that act directly on osteoblasts are regulated by calcium ions (via calcium channels) [17]. A previous study has shown the relationship between CACNG6 and KBD [18]. We found that CACNG6 was down-regulated in the peripheral blood of the KBD patients, which may reflect the differentiation disorder and apoptosis of chondrocytes observed in KBD patients.…”

Section: Discussionmentioning

confidence: 60%

Gene Expression Signature in Endemic Osteoarthritis by Microarray Analysis

Wang¹,

Ning

Zhang

et al. 2015

IJMS

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Kashin-Beck Disease (KBD) is an endemic osteochondropathy with an unknown pathogenesis. Diagnosis of KBD is effective only in advanced cases, which eliminates the possibility of early treatment and leads to an inevitable exacerbation of symptoms. Therefore, we aim to identify an accurate blood-based gene signature for the detection of KBD. Previously published gene expression profile data on cartilage and peripheral blood mononuclear cells (PBMCs) from adults with KBD were compared to select potential target genes. Microarray analysis was conducted to evaluate the expression of the target genes in a cohort of 100 KBD patients and 100 healthy controls. A gene expression signature was identified using a training set, which was subsequently validated using an independent test set with a minimum redundancy maximum relevance (mRMR) algorithm and support vector machine (SVM) algorithm. Fifty unique genes were differentially expressed between KBD patients and healthy controls. A 20-gene signature was identified that distinguished between KBD patients and controls with 90% accuracy, 85% sensitivity, and 95% specificity. This study identified a 20-gene signature that accurately distinguishes between patients with KBD and controls using peripheral blood samples. These results promote the further development of blood-based genetic biomarkers for detection of KBD.

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Section: Discussionmentioning

confidence: 60%

Gene Expression Signature in Endemic Osteoarthritis by Microarray Analysis

Wang¹,

Ning

Zhang

et al. 2015

IJMS

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“…There has been controversy because some authors initially thought that Keshan disease was caused by coxsackievirus B3 viral infection [64,65]. Currently, many other authors attribute Keshan disease to the mycotoxin citreoviridin [60,63,66,67]. Tsunoda et al found that P. citrinum was responsible for yellowish rice, which was associated with the high nephrotoxic toxicity produced by citrinin [53,56].…”

Section: Keshan Diseasementioning

confidence: 99%

“…The gene expression profiles of Kashin-Beck and Keshan diseases occurring within the same endemic areas of China were compared [66]. Total RNA was isolated from peripheral blood mononuclear cells from 36 patients and 28 controls, and gene expression profiles were analyzed using oligonucleotide microarrays.…”

Section: Keshan Diseasementioning

confidence: 99%

Mycotoxins that Affect the Human Cardiovascular System

Carvajal-Moreno¹

2016

J Biomol Res Ther

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“…and Fusarium spp. ), which produce trichothecene (T-2) mycotoxins.The gene expression profiles of Kashin-Beck and Keshan diseases occurring within the same endemic areas of China were compared [66]. Total RNA was isolated from peripheral blood mononuclear cells from 36 patients and 28 controls, and gene expression profiles were analyzed using oligonucleotide microarrays.…”

mentioning

confidence: 99%

“…The comparative toxicogenomics database shows that the expression and biological function of these genes can be affected by multiple environmental factors, including mycotoxin and selenium content, which are potential environmental risk factors for the two diseases. Thus, these shared differentially expressed genes may contribute to the distinct organ lesions caused by the common environmental risk factors for Kashin-Beck and Keshan diseases [66]. …”

mentioning

confidence: 99%

Mycotoxins that Affect the Human Cardiovascular System

Carvajal-Moreno¹

2015

Pharm Anal Acta

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Mycotoxins are toxic secondary metabolites produced by fungi in the field or during storage; these fungi are mainly saprophytic molds growing on foodstuffs or animal feeds. These molds produce chemical compounds of low molecular weight that are not detected by antigens and hence are insidious poisons with no obvious symptoms. Since 1960, mycotoxins have been considered responsible for diseases and death in domestic animals and humans. Mycotoxicoses, the diseases caused by mycotoxins, have been responsible for major epidemics in humans and domestic animals since agriculture was developed. Each of these diseases is caused by specific molds that produce one or more potent toxins, usually in one specific type of commodity or feed. Among the main mycotoxigenic fungi are the genera Aspergillus spp., Penicillium spp. and Fusarium spp.The symptoms caused by mycotoxins can be acute or chronic, depending on the type of toxin and the dose. The symptoms of acute mycotoxicoses include liver and kidney damage, attacks on the central nervous system, skin disorders, hormonal effects, miscarriage, hemorrhage, vomiting, diarrhea and many others. Mycotoxins are eaten in trace quantities in the daily diet; some, such as aflatoxins, can accumulate, whereas others are quickly eliminated. Examples of chronic mycotoxicoses include Reye syndrome, Kwashiorkor, and cancers that develop in experimental animals or humans long after the mycotoxin is eaten. In the present review, we will describe some mycotoxins that cause circulatory problems, vein breakage, hemorrhage, and heart failure. The structures, physicochemical properties [7], biosynthesis [8], production conditions and occurrence of aflatoxins are also well known [9,10]. One important property of aflatoxins is that they form links to DNA, RNA and proteins [11,12], and they accumulate over time as adducts of AFB1-formamidopyrimidine (AFB1-FAPY) [13] and AFB1-lysine albumin [14], which are active carcinogens. Mycotoxins that Affect the Human Cardiovascular SystemMagdaAflatoxins, the most powerful mycotoxins, were discovered in the early 1960s with the outbreak of turkey "X" disease in England and high incidences of liver disease in ducklings in Kenya and hatcheryreared trout in the United States; the causes of all these problems were aflatoxins [15]. Aflatoxins are present in numerous foods, such as cereals, spices [16], oilseeds [17], and dry fruits. After these foods are consumed, the aflatoxins pass into milk, [18,19], all dairy products, eggs [20] and meat [21] derivatives. Aflatoxins are considered unavoidable toxins [22]. Biological control measures include lactic acid bacterial fermentation, which is known to render cereal-based foods and beverages safe [23], and the use of aluminosilicates, glucomannans and optimal storage conditions to prevent fungal growth.Aflatoxin intake is related to kwashiorkor [24] and Reye syndrome [25], and aflatoxins induce liver damage in undernourished individuals [26]. Aflatoxins are classified as Group I carcinogens in humans [27]; the...

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Comparing gene expression profiles of Kashin-Beck and Keshan diseases occurring within the same endemic areas of China

Cited by 17 publications

References 25 publications

Gene Expression Signature in Endemic Osteoarthritis by Microarray Analysis

Gene Expression Signature in Endemic Osteoarthritis by Microarray Analysis

Mycotoxins that Affect the Human Cardiovascular System

Mycotoxins that Affect the Human Cardiovascular System

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