Comparing Four Medicines to Treat Pain from Cryptogenic Sensory Polyneuropathy—The PAIN-CONTRoLS Study

Barohn, Richard; Gajewski, Byron J.; Pasnoor, Mamatha; Brown, Louisa; Herbelin, Laura; Kimminau, Kim S.; Jawdat, Omar; Liu, T; Parks, Cherri; Shlemon, P; Dimachkie, M; Pascuzzi, Robert M.; Ahmed, Arsalan; Wicklund, Matthew; Smith, Graham; Heitzman, Darryl; Ladha, Shafeeq; Pulley, Michael; Li, Y; Ra, Lewis; Sharma, K. Krishna; Tobón, Andrea Catalina Nassar; Walk, David; Brannagan, Thomas; Quan, Dianna; Trivedi, Jaya; Iyadurai, Stanley; Kissel, John T.; Stino, Amro; Wolfe, Gil I.; Hayat, Ghazala; Thaisetthawatkul, Pariwat; Biliciler, Suur; Salajegheh, Kian; Hehir, Maggie; Kolb, Noah; Burns, Ted M.; Bril, Vera; Austin, Sophie K.; Jacoby, Martin; Vu, Thanh Huyen T.; Bazant, Mark; Karam, Chafic; Hussainn, Y; Kutz, Christen; Twydell, Paul; Scelsa, Stephen N.; Kushlaf, Hani; Wymer, James P.; Mallonee, William M.; Ralph, James; Barboi, Alexandru; Verma, Narsingh; Ahmed, Mohammed; Memon, Anza B; Ramchandren, Sindhu; Saperstein, David; Lou, Jennie Q.; Swenson, Andrea; Cash, Theodore

doi:10.25302/05.2020.cer.130602496

Cited by 1 publication

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“…REDCap was used as the data capture system: a secure, web-based platform to collect and manage study data. 27,28 A data and safety monitoring board made recommendations related to trial continuation. Information on the inclusion and exclusion criteria, interventions, assessments, and study results can be found in the Patient-Centered Outcomes Research Institute Final Research Report.…”

Section: Trial Designmentioning

confidence: 99%

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Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS)

Barohn¹,

Pasnoor²,

Brown³

et al. 2021

JAMA Neurol

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and the Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS) Study Team IMPORTANCE Cryptogenic sensory polyneuropathy (CSPN) is a common generalized slowly progressive neuropathy, second in prevalence only to diabetic neuropathy. Most patients with CSPN have significant pain. Many medications have been tried for pain reduction in CSPN, including antiepileptics, antidepressants, and sodium channel blockers. There are no comparative studies that identify the most effective medication for pain reduction in CSPN.OBJECTIVE To determine which medication (pregabalin, duloxetine, nortriptyline, or mexiletine) is most effective for reducing neuropathic pain and best tolerated in patients with CSPN.

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Section: Trial Designmentioning

confidence: 99%

“…Randomization was performed from a central, web-based procedure in REDCap. 27,28 The drug was not provided by the study, so all participants received a prescription. Paying for the drug was the responsibility of the participant.…”

Section: Treatmentmentioning

confidence: 99%