Comparing EndoPAT and BIOPAC measurement of vascular responses to mental stress

Abstract

There are currently no comparison measurements of stress-induced changes in vascular function during acute mental stress tests to measurements made by BIOPAC MP150 systems technology, a standard polygraph device used to detect deception during polygraph examinations in military or law enforcement applications. Vascular responses to reactive hyperaemia and acute mental stress in 25 healthy subjects were measured by both peripheral arterial tonometry (EndoPAT) and a blood pressure cuff attached to a pressure transducer (BIOPAC) and compared. Reactive hyperaemia was performed at baseline and following three acute mental stress tests. There was no difference in vascular reactivity at baseline and following acute mental stress, as measured by EndoPAT or BIOPAC systems (p > 0·05). Mental stress ratios measured by EndoPAT were significantly different than those measured by BIOPAC (p < 0·01). These data suggest that EndoPAT measurements of vascular responses to acute mental stress may be more specific and sensitive than measurements using the BIOPAC system.

Mental stress peripheral vascular reactivity is elevated in women with coronary vascular dysfunction: Results from the NHLBI-sponsored Cardiac Autonomic Nervous System (CANS) study

“…Peripheral endothelial function and vascular reactivity were measured by peripheral arterial tonometric (PAT) plethysmographic device (EndoPAT 2000, Itamar Medical®) as previously described and during supine position, under conditions for MST described above.. 28,29 The deviceconsists of a finger probe with a transducer to assess digital volume changes accompanying pulse-waves. A pressure of 40–70mmHg is applied by the probe to the index fingers for venous occlusion of both hands and arterial pulse amplitude is recorded.…”

“…After 10 minutes of equilibration period, reactive hyperemia index (RHI) is obtained by the following: 5 minutes of baseline amplitude signal detection, 5-minutes of arterial occlusion by suprasystolic blood pressure cuff inflation, and then 6-minutes of post-occlusion amplitude signal detection. RHIis a unit-less measure and a marker of endothelial function, and was determined at baseline and post MST by EndoPAT® automated software which takes into account the baseline signal and adjusts it to the changes in the contralateral arm 15,16,28 . RHI of less than 2.0 has been reported to correlate with coronary endothelial dysfunction and coronary artery disease, and is prognostic (sensitivity and specificity of ~80%).…”

“…SPR was obtained from the arm not wearing a BP cuff and determined for each MST task, as a measure of vasoconstriction, where less than 0.8 is considered abnormal. 28,33…”

Differential effects of EPA versus DHA on postprandial vascular function and the plasma oxylipin profile in men

“…The primary outcome for the trial was the EndoPAT RHI index, with PWV and AIx as secondary outcomes. For EndoPAT, given an SD of 0.4 ( 26 ), a clinically relevant difference of 0.25 between treatments would be detectable in 21 subjects per treatment group. For PWV, given an SD of 1.2 m/s ( 27 ), a clinically relevant difference of 1.5 m/s would be detectable with a sample size of 11 participants per treatment group.…”

Bioethical differences between drug addiction treatment professionals inside and outside the Russian Federation

“…In spite of the fact that narcology has a psychiatric component, the standards of bioethics and medical law that are observed in psychiatry [ 12 - 17 ] are not always applied to it. The legitimacy and expediency of applying the norms dictated by the Russian Federation law "Concerning Psychiatric Care and Guaranteeing Patient Rights" [ 18 ] to drug addicts are still being debated today [ 19 , 20 ].…”