Comparing effects of low glycemic index/high-fat, high-calorie diet and high-fat, high-calorie diet on cytokine levels of patients with cystic fibrosis: A randomized controlled clinical trial

Gorji, Zahra; Modaresi, Mohammadreza; Yekanni-Nejad, Saeed; Rezaei, Nima; Mahmoudi, Maryam

doi:10.1684/ecn.2020.0442

Eur Cytokine Netw

2020

DOI: 10.1684/ecn.2020.0442

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Comparing effects of low glycemic index/high-fat, high-calorie diet and high-fat, high-calorie diet on cytokine levels of patients with cystic fibrosis: A randomized controlled clinical trial

Zahra Gorji

Mohammadreza Modaresi

Saeed Yekanni-Nejad

et al.

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Cited by 2 publications

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Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases

Tang

Dong

et al. 2021

IJMS

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Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that most often occur after an overreactive immune system is activated by an acute systemic infection. A variety of cells participate in cytokine storm induction and progression, with profiles of cytokines released during cytokine storm varying from disease to disease. This review focuses on pathophysiological mechanisms underlying cytokine storm induction and progression induced by pathogenic invasive infectious diseases. Strategies for targeted treatment of various types of infection-induced cytokine storms are described from both host and pathogen perspectives. In summary, current studies indicate that cytokine storm-targeted therapies can effectively alleviate tissue damage while promoting the clearance of invading pathogens. Based on this premise, “multi-omics” immune system profiling should facilitate the development of more effective therapeutic strategies to alleviate cytokine storms caused by various diseases.

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Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases

Tang

Dong

et al. 2021

IJMS

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Recovery of ΔF508-CFTR Function by Citrate

Borkenhagen

Prehm

2022

Nutrients

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Treatment of cystic fibrosis relies so far on expensive and sophisticated drugs. A logical approach to rescuing the defective ΔF508-CFTR protein has not yet been published. Therefore, virtual docking of ATP and CFTR activators to the open conformation of the CFTR protein was performed. A new ATP binding site outside of the two known locations was identified. It was located in the cleft between the nucleotide binding domains NBD1 and NBD2 and comprised six basic amino acids in close proximity. Citrate and isocitrate were also bound to this site. Citrate was evaluated for its action on epithelial cells with intact CFTR and defective ΔF508-CFTR. It activated hyaluronan export from human breast carcinoma cells and iodide efflux, and recovered ΔF508-CFTR from premature intracellular degradation. In conclusion, citrate is an activator for ΔF508-CFTR and increases export by defective ΔF508-CFTR into the extracellular matrix of epithelial cells.

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Comparing effects of low glycemic index/high-fat, high-calorie diet and high-fat, high-calorie diet on cytokine levels of patients with cystic fibrosis: A randomized controlled clinical trial

Cited by 2 publications

References 44 publications

Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases

Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases

Recovery of ΔF508-CFTR Function by Citrate

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