Comparing Effectiveness of Letrozole Versus Clomiphene Citrate to Evaluate the Ovulation Induction in patients with POS

Abstract

Background: Anovulation is the commonest cause of female infertility and polycystic ovarian syndrome (PCOS) is the most frequently seen cause of anovulation among infertile females. Letrozole and Clomiphene Citrate are two common drugs for PCOS. But controversial data was noticed regarding their effectiveness. Aim: To compare effectiveness of Letrozole versus Clomiphene Citrate to evaluate the ovulation induction in patients with polycystic ovarian syndrome Methods: After fulfilling the selection criteria, total 360 females were enrolled according to calculated sample size and were randomly divided into two equal groups. One is treated with letrozole and other is clomiphene citrate. Successful ovulation was noted on follow up. Data was collected in proforma and later on analyzed in SPSS version 23. Results: The mean age of patients in letrozole group was 26.61± 4.81 years and in clomiphene citrate was it 27.89±4.24 years. Successful ovulation induction was noted in 172 with letrozole and 150 with clomiphene citrate i. e p-value=0.001. Conclusion: Letrozole has significantly better efficacy for successful ovulation than Clomiphene Citrate for PCOS. Keywords: Ovulation, Clomiphene citrate, Letrozole, polycystic ovarian syndrome

Strong early impact of letrozole on ovulation induction outperforms clomiphene citrate in polycystic ovary syndrome: a systematic review with meta-analysis

“…S15 Fig. Risk of bias assessment of the studies included in the meta-analysis assessing endometrial thickness (ET) [1, 4, 5, 16, 19, 41, 43–46, 56] using the revised tool for assessing risk of bias in randomized trials (Rob 2). Legend: +: low risk; !…”

“…S16 Fig. Risk of bias assessment of the studies included in the meta-analysis assessing endometrial thickness (ET) [1, 4, 5, 16, 19, 41, 43–46, 56] broken down to tools, shown in percentage.…”