Comparing diffusion‐weighted and T2‐weighted MR imaging for the quantification of infarct size in a neonatal rat hypoxic–ischemic model at 24 h post‐injury

Abstract

At 24h post-HI, lesion size on DWI, using 80% ADC threshold is the best predictor of final infarct volume. Although T2WI performed less well, it has the advantage of superior spatial resolution and is technically less demanding. These are important considerations for experiments which utilize MRI as a surrogate method for lesion quantification in the neonatal rat HI model.

Sex differences in brain MRI abnormalities and neurodevelopmental outcomes in a rat model of neonatal hypoxia-ischemia

“…Acquisition time was about 6 minutes. MRI was carried out 3 days (P10) and 60 days (P67) after the hypoxicischemic insult; the selection of these time points was based on previous studies [26][27][28][29][30]. Lesion size was measured from the acquired images using Analyze 5.0 software (Biomedical Imaging Resource, Mayo Clinic, Rochester, MN, USA).…”

Characterization of White Matter Injury in a Hypoxic-Ischemic Neonatal Rat Model by Diffusion Tensor MRI

“…Previous animal studies 2,3,5,9,10 have demonstrated that conventional MRI sequences such as T1-weighted imaging (T1WI) and T2-weighted imaging (T2WI), and diffusion-weighted imaging (DWI) measuring trace, could detect HI-induced brain damage. Diffusion tensor MR imaging (DTI) allows the measurement of the directional diffusivities of water and is more sensitive than conventional MRI sequences in detecting WM 1 injury.…”

Functional MRI of postnatal visual development in normal rat superior colliculi

“…It has also been shown that the cerebral cortex has the ability to adapt to altered sensory inputs and can undergo massive restructuring of neuronal circuits during functional reorganization [22]. While the present study showed occasional activations of the visual cortex upon the current stimulation and scanning parameters, further experiments will be performed to understand the functional development of the visual cortex in the same rat developmental model, and the functional impairment and restoration in both the superior colliculus and the visual cortex in the well-established rat model of neonatal hypoxic-ischemic cerebral injury [23][24][25][26][27][28].…”