Comparing Child-Pugh, MELD, and FIB-4 to Predict Clinical Outcomes in Hepatitis C Virus-Infected Persons: Results From ERCHIVES

Butt, Adeel A.; Ren, Yanjie; Re, Vincent Lo; Taddei, Tamar H.; Kaplan, David E.

doi:10.1093/cid/cix224

Cited by 34 publications

(34 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Depending on the total points, Child-Pugh score can be divided into grade A (5–6 points), B (7–9 points) and C (10–15 points) [18]. The MELD score was calculated using the formula: 11.2 × ln (international normalized ratio) + 9.57 × ln (creatinine, mg/dL) + 3.78 × ln (bilirubin, mg/dL) + 6.43 [19]. Clinically significant portal pressure (CSPH) was defined as the presence of esophageal varices or in those with a low platelet count (<100 ×10 9 /L) with splenomegaly [20].…”

Section: Methodsmentioning

confidence: 99%

A Comparative Study of Albumin-Bilirubin Score with Child-Pugh Score, Model for End-Stage Liver Disease Score and Indocyanine Green R15 in Predicting Posthepatectomy Liver Failure for Hepatocellular Carcinoma Patients

Zou

Yang

et al. 2018

Dig Dis

View full text Add to dashboard Cite

Background: The albumin-bilirubin (ALBI) grade is a newly proposed model for assessing the hepatic function. This study aimed to compare the value of the ALBI score with Child-Pugh score, model for end-stage liver disease (MELD) score and indocyanine green (ICG) R15 in predicting posthepatectomy liver failure (PHLF). Methods: Patients undergoing curative resection for hepatocellular carcinoma (HCC) between January 2014 and June 2017 were enrolled. The values of the Child-Pugh score, MELD score, ICG R15 and ALBI score in predicting PHLF were evaluated. Results: A total of 473 HCC patients were enrolled. The ALBI score was identified as an independent predictor of PHLF. The AUCs for the Child-Pugh score, MELD score, ICG R15 and ALBI score in predicting PHLF were 0.665, 0.649, 0.668, and 0.745 respectively. Multivariable analyses revealed that the ALBI score was an independent predictor of PHLF regardless of the hepatectomy subgroups, but the Child-Pugh score and MELD score were not significant predictors of PHLF both in major and minor hepatectomy subgroups, and ICG R15 was only a significant predictor of PHLF in minor hepatectomy subgroup. Conclusion: The ALBI score showed superior predictive value of PHLF over Child-Pugh score, MELD score and ICG R15. We propose to use the ALBI score to evaluate surgical risk for HCC patients undergoing hepatic resection.

show abstract

Section: Methodsmentioning

confidence: 99%

A Comparative Study of Albumin-Bilirubin Score with Child-Pugh Score, Model for End-Stage Liver Disease Score and Indocyanine Green R15 in Predicting Posthepatectomy Liver Failure for Hepatocellular Carcinoma Patients

Zou

Yang

et al. 2018

Dig Dis

View full text Add to dashboard Cite

show abstract

“…Persons with advanced liver fibrosis at baseline (FIB-4 score >3.25) had a higher incidence, and had a higher risk, of CVD events compared with those with no or minimal fibrosis (FIB-4 score <1. 25). However, at all levels of liver fibrosis, those who received treatment had a consistently lower incidence of CVD events compared with those who did not receive treatment.…”

Section: March 2019mentioning

confidence: 88%

“…The ERCHIVES is updated regularly to include veterans with a new diagnosis of HCV and has been described in detail in multiple previous publications. [19][20][21][22][23][24][25] For the present study, we identified all persons with confirmed chronic HCV infection (positive for HCV antibody and !1 HCV RNA). We excluded those with human immunodeficiency virus coinfection and hepatitis B virus coinfection.…”

Section: Study Populationmentioning

confidence: 99%

Direct-Acting Antiviral Therapy for HCV Infection Is Associated With a Reduced Risk of Cardiovascular Disease Events

et al. 2019

View full text Add to dashboard Cite

is associated with an increased risk of cardiovascular disease (CVD) events. It is not clear whether treatment with directacting antiviral (DAA) agents affects risk of CVD. METHODS:We searched the Electronically Retrieved Cohort of HCV-Infected Veterans database for patients with chronic HCV infection (n ¼ 242,680) and identified patients who had been treated with a pegylated interferon and ribavirin regimen (n ¼ 4436) or a DAA-containing regimen (n ¼ 12,667). Treated patients were matched for age, race, sex, and baseline values with patients who had never received treatment for HCV infection (controls). All subjects were free of any CVD event diagnosis of HCV infection at baseline. The primary outcome was incident CVD events, identified by International Classification of Diseases, Ninth Edition, Clinical Modification or International Classification of Diseases, Tenth Edition code, in the different groups and in patients with vs without a sustained virologic response to therapy. RESULTS: There were 1239 (7.2%) incident CVD events in the treated groups and 2361 (13.8%) events in the control group. Incidence rates were 30.9 per 1000 patient-years (95% CI 29.6-32.1) in the control group and 20.3 per 1000 patientyears (95% CI 19.2-21.5) in the treated groups (P < .0001). Treatment with pegylated interferon and ribavirin (hazard ratio 0.78; 95% CI 0.71-0.85) or a DAA regimen (hazard ratio 0.57; 95% CI 0.51-0.65) was associated with a significantly lower risk of a CVD event compared with no treatment (controls). Incidence rates for CVD events were 23.5 per 1000 patient-years (95% CI 21.8-25.3) in the group treated with the pegylated interferon and ribavirin regimen, 16.3 per 1000 patient-years (95% CI 14.7-18.0) in the group treated with a DAA regimen, and 30.4 (95% CI 29.2-31.7) in the control group. A sustained virologic response was associated with a lower risk of incident CVD events (hazard ratio 0.87; 95% CI 0.77-0.98). CONCLUSIONS: In an analysis of a cohort of HCV-infected veterans, treatment of HCV infection was associated with a significant decrease in risk of CVD events. Patients treated with a DAA regimen and patients who achieved sustained virologic responses had the lowest risk for CVD events.

show abstract

“…Determination of the CP class was performed according to methods published previously [ 25 ]. The model of end-stage liver disease (MELD) score was computed applying the formula: 9.57 × ln(creatinine [mg/dl]) + 11.2 × ln(INR) + 3.78 × ln(bilirubin [mg/dl]) + 6.43 [ 26 ]. The calculation of the ALBI score used this equation: ALBI score = − 0.085 × (albumin [g l − 1 ]) + 0.66 × log 10 (total bilirubin [μmol l − 1 ]), and was further categorized into three different grades: grade 3 (> − 1.39), grade 2 (> − 2.60 to ≤ − 1.39), and grade 1 (≤ − 2.60) [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

Ability of the ALBI grade to predict posthepatectomy liver failure and long-term survival after liver resection for different BCLC stages of HCC

Zhang

Zhou

et al. 2018

World J Surg Onc

View full text Add to dashboard Cite

BackgroundUnderlying liver function is a major concern when applying surgical resection for hepatocellular carcinoma (HCC). We aimed to explore the capability of the albumin-bilirubin (ALBI) grade to predict post-hepatectomy liver failure (PHLF) and long-term survival after hepatectomy for HCC patients with different Barcelona Clinic Liver Cancer (BCLC) stages.MethodsBetween January 2010 and December 2014, 338 HCC patients who were treated with liver resection were enrolled. The predictive accuracy of ALBI grade system for PHLF and long-term survival across different BCLC stages was examined.ResultsA total of 26 (7.7%) patients developed PHLF. Patients were divided into BCLC 0/A and BCLC B/C categories. ALBI score was found to be a strong independent predictor of PHLF across different BCLC stages by multivariate analysis. In terms of overall survival (OS), it exhibited high discriminative power in the total cohort and in BCLC 0/A subgroup. However, differences in OS between ALBI grade 1 and 2 patients in BCLC B/C subgroup were not significant (P = 0.222).ConclusionThe ALBI grade showed good predictive ability for PHLF in HCC patients across different BCLC stages. However, the ALBI grade was only a significant predictor of OS in BCLC stage 0/A patients and failed to predict OS in BCLC stage B/C patients.Electronic supplementary materialThe online version of this article (10.1186/s12957-018-1500-9) contains supplementary material, which is available to authorized users.

show abstract

Comparing Child-Pugh, MELD, and FIB-4 to Predict Clinical Outcomes in Hepatitis C Virus-Infected Persons: Results From ERCHIVES

Abstract: FIB-4 score is a better predictor of HD and HCC in HCV-positive persons. A score of <3 is associated with a low risk of HD and HCC 1 and 3 years after HCV diagnosis.

Cited by 34 publications

References 29 publications

A Comparative Study of Albumin-Bilirubin Score with Child-Pugh Score, Model for End-Stage Liver Disease Score and Indocyanine Green R15 in Predicting Posthepatectomy Liver Failure for Hepatocellular Carcinoma Patients

A Comparative Study of Albumin-Bilirubin Score with Child-Pugh Score, Model for End-Stage Liver Disease Score and Indocyanine Green R15 in Predicting Posthepatectomy Liver Failure for Hepatocellular Carcinoma Patients

Direct-Acting Antiviral Therapy for HCV Infection Is Associated With a Reduced Risk of Cardiovascular Disease Events

Ability of the ALBI grade to predict posthepatectomy liver failure and long-term survival after liver resection for different BCLC stages of HCC

Contact Info

Product

Resources

About