Comparing brains by matching connectivity profiles

Mars, Rogier B.; Verhagen, Lennart; Gladwin, Thomas; Neubert, Franz-Xaver; Sallet, Jérôme; Rushworth, Matthew F. S.

doi:10.1016/j.neubiorev.2015.10.008

Cited by 123 publications

(144 citation statements)

References 43 publications

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“…Connectivity‐based parcellation analysis [CBP, Johansen‐Berg et al, ; for reviews see Eickhoff et al, ; Mars et al, ] groups voxels into an area if they show a common pattern of structural brain connectivity with the rest of the brain—distinct from that in neighboring voxels. In the present review, we use connectivity‐based parcellation atlases of TPJ and adjacent IPL that are based on diffusion weighted imaging data [Mars et al, , ].…”

Section: Methodsmentioning

confidence: 99%

Specifying the brain anatomy underlying temporo-parietal junction activations for theory of mind: A review using probabilistic atlases from different imaging modalities

et al. 2017

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In this quantitative review, we specified the anatomical basis of brain activity reported in the Temporo-Parietal Junction (TPJ) in Theory of Mind (ToM) research. Using probabilistic brain atlases, we labeled TPJ peak coordinates reported in the literature. This was carried out for four different atlas modalities: (i) gyral-parcellation, (ii) sulco-gyral parcellation, (iii) cytoarchitectonic parcellation and (iv) connectivity-based parcellation. In addition, our review distinguished between two ToM task types (false belief and social animations) and a nonsocial task (attention reorienting). We estimated the mean probabilities of activation for each atlas label, and found that for all three task types part of TPJ activations fell into the same areas: (i) Angular Gyrus (AG) and Lateral Occpital Cortex (LOC) in terms of a gyral atlas, (ii) AG and Superior Temporal Sulcus (STS) in terms of a sulco-gyral atlas, (iii) areas PGa and PGp in terms of cytoarchitecture and (iv) area TPJp in terms of a connectivity-based parcellation atlas. Beside these commonalities, we also found that individual task types showed preferential activation for particular labels. Main findings for the right hemisphere were preferential activation for false belief tasks in AG/PGa, and in Supramarginal Gyrus (SMG)/PFm for attention reorienting. Social animations showed strongest selective activation in the left hemisphere, specifically in left Middle Temporal Gyrus (MTG). We discuss how our results (i.e., identified atlas structures) can provide a new reference for describing future findings, with the aim to integrate different labels and terminologies used for studying brain activity around the TPJ. Hum Brain Mapp 38:4788-4805, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Methodsmentioning

confidence: 99%

Specifying the brain anatomy underlying temporo-parietal junction activations for theory of mind: A review using probabilistic atlases from different imaging modalities

et al. 2017

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“…Connectivity fingerprints can then be compared by calculating the Manhattan distance between them (Mars et al, 2016b).…”

Section: Connectivity Fingerprintsmentioning

confidence: 99%

Two fiber pathways connecting amygdala and prefrontal cortex in humans and monkeys

Folloni

Sallet

Khrapitchev

et al. 2019

Preprint

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The interactions between amygdala and prefrontal cortex are pivotal to many neural processes involved in learning, decision-making, emotion, and social regulation. The broad functional role of amygdala-prefrontal interplay may reflect the diversity of its anatomical connections. Little, however, is known of the structural wiring linking amygdala and prefrontal cortex in humans. Using diffusion imaging techniques, we reconstructed connections between amygdala, anterior temporal and prefrontal cortex in human and macaque brains. First, by studying macaques we were able to assess which aspects of connectivity known from tracer studies could be identified with diffusion imaging. Second, by comparing diffusion imaging results in humans and macaques we were able to estimate amygdala-prefrontal connection patterns in humans and compare them with those in the monkey. We observed a prominent and well-preserved bifurcation of connections between amygdala and frontal lobe into two fiber networksan amygdalofugal path and an uncinate fascicle pathin both species.There has recently been a particular focus on understanding amygdala-prefrontal pathways in health and disease. These neural circuits have been implicated with reward-based learning and decision-making (De Martino et al.

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“…Finally, permutation testing was used to test for significant differences in the Manhattan distance between fingerprints of the two subregions, as described in Mars et al (2016). For each hemisphere we tested the hypothesis that the difference between the anatomical connectivity fingerprints to be compared would be larger (or smaller) than expected by chance.…”

Section: Anatomical Connectivity Patterns Of the Psts Subregionsmentioning

confidence: 99%

Rostro‐caudal organization of the human posterior superior temporal sulcus revealed by connectivity profiles

Chen

Fan

Xia

et al. 2018

Human Brain Mapping

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The posterior superior temporal sulcus (pSTS) plays an important role in biological motion perception but is also thought to be essential for speech and facial processing. However, although there are many previous investigations of distinct functional modules within the pSTS, the functional organization of the pSTS in its full functional heterogeneity has not yet been established. Here we applied a connectivity‐based parcellation strategy to delineate the human pSTS subregions based on distinct anatomical connectivity profiles and divided it into rostral and caudal subregions using diffusion tensor imaging. Subsequent multimodal connection pattern analyses revealed distinct subregional connectivity profiles. From this we inferred that the two subregions are involved in distinct functional circuits, the language processing loop and the cognition attention network. These results indicate a convergent functional architecture of the pSTS that can be revealed based on different types of connectivity and is reflected in different functions and interactions. In addition, when the subregions were performing their processing in the different functional circuits, we found asymmetry in the bilateral pSTS. Our findings may improve the understanding of the functional organization of the pSTS and provide new insights into its interactions and integration of information at the subregional level.

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Comparing brains by matching connectivity profiles

Cited by 123 publications

References 43 publications

Specifying the brain anatomy underlying temporo-parietal junction activations for theory of mind: A review using probabilistic atlases from different imaging modalities

Specifying the brain anatomy underlying temporo-parietal junction activations for theory of mind: A review using probabilistic atlases from different imaging modalities

Two fiber pathways connecting amygdala and prefrontal cortex in humans and monkeys

Rostro‐caudal organization of the human posterior superior temporal sulcus revealed by connectivity profiles

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