Comparing Asthma Control Questionnaire (ACQ) and National Asthma Education and Prevention Program (NAEPP) asthma control criteria

Rhee, Hyekyun; Love, Tanzy; Mammen, Jennifer R.

doi:10.1016/j.anai.2018.09.448

Cited by 12 publications

(10 citation statements)

References 43 publications

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“…ACQ responder rates in this Chinese asthma patient subpopulation with both doses of tiotropium and salmeterol were not statistically different from that of placebo although a significant improvement in FEV1 was demonstrated; the differences in the overall study population were statistically significant 11. The reliability of ACQ in predicting lung function has been debated due to its nature as a patient self-reported questionnaire, where the constructs are indirectly measured and the methods for gathering information may be vulnerable to memory bias 12. For this study, the lack of differences could possibly be due to the small patient size and the known placebo effects in assessing improvement in asthma control 13…”

Section: Discussionmentioning

confidence: 79%

Add-on Tiotropium in Chinese Patients With Moderate Asthma: A Pooled Subgroup Analysis of MezzoTinA-Asthma 1 and 2

Lin

Wan

Kang

et al. 2019

Allergy Asthma Immunol Res

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Purpose Asthma affects approximately 30 million patients in China; however, tiotropium data for Chinese patients is limited. This study aimed to assess the efficacy and safety of tiotropium in Chinese patients with moderate symptomatic asthma. Methods A post hoc subgroup analysis was conducted on 430 Chinese patients pooled from two 24-week, replicate phase 3 trials ( NCT01172808 and NCT01172821 ), in which they received once-daily tiotropium 2.5 µg (Tio R2.5) or 5 µg (Tio R5) (n = 106 or 109, respectively), twice-daily salmeterol 50 µg (Sal 50) (n = 110), or placebo (n = 105), while maintaining inhaled corticosteroids (ICS). The co-primary endpoints assessed in week 24 were forced expiratory volume in 1 second (FEV1) peak 0–3h response, trough FEV1 response, and responder rate as assessed using the Asthma Control Questionnaire (ACQ). Results For both FEV1 peak 0–3h responses and trough FEV1 responses, the mean treatment differences were greater for Tio R2.5, Tio R5, and Sal 50 compared with placebo at 0.249 L, 0.234 L, and 0.284 L, and 0.172 L, 0.180 L, and 0.164 L, respectively ( P < 0.001). The ACQ responder rate in placebo, Tio R2.5, Tio R5, and Sal 50 was 58.7%, 62.3%, 59.3%, and 69.1%, respectively. Furthermore, 11 (2.6%) of 430 patients had serious adverse events (Tio R5, n = 4; Tio R2.5, n = 1; Sal 50, n = 1; and placebo, n = 5). Conclusions Once-daily tiotropium, as add-on to medium-dose ICS, was effective and well tolerated for Chinese patients with moderate symptomatic asthma, consistent with the main analysis.

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Section: Discussionmentioning

confidence: 79%

Add-on Tiotropium in Chinese Patients With Moderate Asthma: A Pooled Subgroup Analysis of MezzoTinA-Asthma 1 and 2

Lin

Wan

Kang

et al. 2019

Allergy Asthma Immunol Res

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“…Other key clinical indicators also supported this result. The asthma control questionnaire (ACQ) is the most widely used standardized questionnaire for asthma control and can evaluate the control degree of patients stably and effectively ( 36 – 38 ). The FEV1 reversibility is a marker of airway hyper-responsiveness (AHR) and has traditionally been considered positively correlated with the severity of asthma ( 39 , 40 ).…”

Section: Resultsmentioning

confidence: 99%

Autophagy-Related Genes Are Involved in the Progression and Prognosis of Asthma and Regulate the Immune Microenvironment

et al. 2022

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BackgroundAutophagy has been proven to play an important role in the pathogenesis of asthma and the regulation of the airway epithelial immune microenvironment. However, a systematic analysis of the clinical importance of autophagy-related genes (ARGs) regulating the immune microenvironment in patients with asthma remains lacking.MethodsClustering based on the k-means unsupervised clustering method was performed to identify autophagy-related subtypes in asthma. ARG-related diagnostic markers in low-autophagy subtypes were screened, the infiltration of immune cells in the airway epithelium was evaluated by the CIBERSORT, and the correlation between diagnostic markers and infiltrating immune cells was analyzed. On the basis of the expression of ARGs and combined with asthma control, a risk prediction model was established and verified by experiments.ResultsA total of 66 differentially expressed ARGs and 2 subtypes were identified between mild to moderate and severe asthma. Significant differences were observed in asthma control and FEV1 reversibility between the two subtypes, and the low-autophagy subtype was closely associated with severe asthma, energy metabolism, and hormone metabolism. The autophagy gene SERPINB10 was identified as a diagnostic marker and was related to the infiltration of immune cells, such as activated mast cells and neutrophils. Combined with asthma control, a risk prediction model was constructed, the expression of five risk genes was supported by animal experiments, was established for ARGs related to the prediction model.ConclusionAutophagy plays a crucial role in the diversity and complexity of the asthma immune microenvironment and has clinical value in treatment response and prognosis.

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“…Because asthma is a highly variable disease, symptoms might fluctuate substantially from day-to-day [24], and for that reason, the pretesting ACQ questionnaire was used to not evaluate FeNO in a patient with asthma exacerbation. Statistical analysis.…”

Section: Visit Methodologymentioning

confidence: 99%

Modification of exhaled air nitric oxide in patients with asthma – cortisone monotherapy or dual inhalation therapy?

Ruta

Motoc

Todea

et al. 2020

Ann Agric Environ Med.

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Comparing Asthma Control Questionnaire (ACQ) and National Asthma Education and Prevention Program (NAEPP) asthma control criteria

Abstract: ClinicalTrials.gov Identifier: NCT02293499.

Cited by 12 publications

References 43 publications

Add-on Tiotropium in Chinese Patients With Moderate Asthma: A Pooled Subgroup Analysis of MezzoTinA-Asthma 1 and 2

Add-on Tiotropium in Chinese Patients With Moderate Asthma: A Pooled Subgroup Analysis of MezzoTinA-Asthma 1 and 2

Autophagy-Related Genes Are Involved in the Progression and Prognosis of Asthma and Regulate the Immune Microenvironment

Modification of exhaled air nitric oxide in patients with asthma – cortisone monotherapy or dual inhalation therapy?

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