Compared Localizations of Prolactin-Like and Adrenocorticotropin Immunoreactivities within the Brain of the Rat

Toubeau, Gérard; Desclin, Jean; Parmentier, Marc; Pasteels, Jean Lambert

doi:10.1159/000122948

Cited by 61 publications

(24 citation statements)

References 24 publications

(36 reference statements)

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“…Immunoreactive LH was also found in scattered cells of the pars tuberalis, in agreement with findings from other stud ies [7,8], The distribution of radioimmunoassayble LH in the rat brain is rather similar to that also reported for ACTH [13,16,19] and TSH [15]. It is of interest to note also that the distribution of stained neural elements is simular to that reported for ACTH [26] and prolactin [25] although much less intense than that obtained by us for ACTH [10]. This suggests that several adenohypophysial principles may coexist in separate or identical arcuate perikarya, and that their fiber processes project to hypothalamic and extrahypothalamic sites.…”

Section: Discussionsupporting

confidence: 91%

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Presence of Immunoreactive Luteinizing Hormone in the Rat Forebrain

Hostetter¹,

Gallo²,

Brownfield³

1981

Neuroendocrinology

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This study demonstrates the presence of immunoreactive LH in rat brain by radioimmunoassay and immunocytochemistry. High levels of radioimmunoassayable LH were identified in the hypothalamus, while significant but lesser quantities were found in the amygdala, septal area, preoptic area, thalamus, caudate nucleus, and hippocampus. Correlative immunocytochemistry localized immunopositive fibers in hypothalamic and serveral extrahypothalamic brain structures. Immunoreactive cell bodies were seen in colchicine-treated rats in the arcuate nucleus of the hypothalamus. Gel chromatography of hypothalamic extracts revealed that immunoassayable LH coeluted with LH standard and rat pituitary extracts. Possible mechanisms related to the origin and function of neuronal LH are discussed.

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Section: Discussionsupporting

confidence: 91%

“…Obviously, this suggestion requires further careful studies of antibody specificity and possible antigen ic cross reactivity. However, supporting evidence for this suggestion comes from the localization of prolactin and ACTH within the same arcuate perikarya [25].…”

Section: Discussionmentioning

confidence: 95%

Presence of Immunoreactive Luteinizing Hormone in the Rat Forebrain

Hostetter¹,

Gallo²,

Brownfield³

1981

Neuroendocrinology

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“…The selective localization of positive cells in the peripheral part of the paraventricular nucleus and in the dorsal part of the supraoptic nucleus is similar to the localization of oxytocin neurones (24); in view of the number of positive magnocellular cells and of positive posthypophyseal fibers, it can be suggested that this positive material is located mainly in oxytocin neurons. Such a localization of two unrelated peptides in the same neuron has been described for corticotropin and prolactin in the hypothalamic arcuate, ventromedial, and premamillary nuclei (25).…”

Section: Methodssupporting

confidence: 60%

Immunohistochemical localization of cholecystokinin- and gastrin-like peptides in the brain and hypophysis of the rat

Vanderhaeghen¹,

Lotstra²,

Mey³

et al. 1980

Proc. Natl. Acad. Sci. U.S.A.

358

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ABSIRACT The distribution of gastrin-cholecystokinin-like peptide(s) is reported in brain and hypophysis of the rat. The unlabeled peroxidase-antiperoxidase complex immunohistochemical technique was used. Controls of specificity for various peptides were studied with solid-phase absorption. Colchicine treatment was necessary to obtain positivity in many neuronal cell bodies. In addition to their already known distribution, gastrin-cholecystokinins containing neural cell bodies and fibers were present in olfactory structures, in various preoptic and hypothalamic nuclei (except in mamillary bodies), in mesencephalic nucleus linearis rostralis, and in A-10, A-9, and A-8 regions of Dahlstrom and Fuxe, which include substantia nigra. From previous investigations and the present distribution study, it can be inferred that, although most of the brain material consists of cholecystokinin, gastrins may also be present in hypothalamo-posthypophyseal magnocellular cells, in nucleus tractus solitarii, and in the dorsal horn of the spinal cord. The distribution of positive cell bodies in the peripheral part of the paraventricular nucleus and in the dorsal part of the supraoptic nuclei in the hypothalamus is similar to that of oxytocin neurons.

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“…We have previously shown that T implants in the POA-SCN can specifically inhibit DA turnover locally [33]. There are some neurons in the rostral POA regions which contain 'prolactin-like' material [12,38,39] and electrophysiological studies have also identified prolactin-responsive neu rons in the POA [8]. The results of the present studies further reveal the existence of a complex interaction between the androgen-concentrating neurons [35,36] and prolactin-re sponsive cells in the POA-SCN [8] to modulate the activity of DA neurons locally.…”

Section: Discussionmentioning

confidence: 99%

Hyperprolactinemia Counteracts the Testosterone-Induced Inhibition of the Preoptic Area Dopamine Turnover

Kalra¹,

Simpkins²,

Kalra³

1981

Neuroendocrinology

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The present study was undertaken to determine the effects of hyperprolactinemia on dopamine (DA) concentrations and turnover rates in the medial basal hypothalamus (MBH) and the preoptic area-suprachiasmatic nucleus region (POA-SCN) in castrated and castrated, testosterone (T) implanted male rats. Subcutaneous implants, which raised serum T levels to those found in intact rats, decreased serum LH to basal levels but did not alter DA turnover in the MBH. Anterior pituitary (AP) transplants under the renal capsule increased serum prolactin to 60–110 ng/ml, and accelerated DA turnover by nearly 2-fold in the MBH of both castrated and castrated, T-implanted rats without influencing serum LH levels. While T implants caused a decrease in the POA-SCN DA turnover, high serum prolactin levels produced by AP implants in castrated rats were ineffective in altering POA-SCN DA turnover. However, in the presence of physiological levels of T, these elevated serum prolactin levels not only blocked the T-induced decrease in POA-SCN DA turnover, but further augmented DA turnover over that observed in the castrated or castrated, T-implanted rats. These results indicate that (i) for acceleration of the MBH DA turnover by prolactin T priming is not essential and it appears to occur at serum prolactin levels which do not depress serum LH levels, and (ii) the stimulatory effects of prolactin on the POA-SCN DA turnover are dependent upon the presence of circulating T. Since these synergistic effects of prolactin and T on the POA-SCN DA turnover are not involved in the regulation of gonadotropin secretion, their participation in attenuation of male sexual behavior associated with hyperprolactinemia is discussed.

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Compared Localizations of Prolactin-Like and Adrenocorticotropin Immunoreactivities within the Brain of the Rat

Cited by 61 publications

References 24 publications

Presence of Immunoreactive Luteinizing Hormone in the Rat Forebrain

Presence of Immunoreactive Luteinizing Hormone in the Rat Forebrain

Immunohistochemical localization of cholecystokinin- and gastrin-like peptides in the brain and hypophysis of the rat

Hyperprolactinemia Counteracts the Testosterone-Induced Inhibition of the Preoptic Area Dopamine Turnover

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