Compared effects of two beryllium salts (soluble and insoluble): Toxicity and blockade of the reticuloendothelial system

Vacher, J; Deraedt, R.; Benzoni, J.

doi:10.1016/0041-008x(73)90056-2

Cited by 22 publications

(2 citation statements)

References 10 publications

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“…Even if the reported LD50 values for Be2+ and In3+ are very similar their toxicological mechanisms probably differ. Dissolved Be2+ given intravenously, is thus reported to be more toxic than insoluble Be-phosphate (458). The difference compared to In3+ could probably be due to dissolved Be2+ not being metabolized via transferrin and the lysosomes and being more easily taken up by the cell cytosol than the trivalent ions.…”

Section: General Discussion On Metabolism and Effects Of Al3+mentioning

confidence: 99%

Metabolism and possible health effects of aluminum.

Ganrot¹

1986

Environ Health Perspect

203

150

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Literature regarding the biochemistry of aluminum and eight similar ions is reviewed. Close and hitherto unknown similarities were found. A hypothetical model is presented for the metabolism, based on documented direct observations of Al3+ and analogies from other ions. Main characteristics are low intestinal absorption, rapid urinary excretion, and slow tissue uptake, mostly in skeleton and reticuloendothelial cells. Intracellular Al3+ is probably first confined in the lysosomes but then slowly accumulates in the cell nucleus and chromatin. Large, long-lived cells, e.g., neurons, may be the most liable to this accumulation. In heterochromatin, Al3+ levels can be found comparable to those used in leather tannage. It is proposed that an accumulation may take place at a subcellular level without any significant increase in the corresponding tissue concentration. The possible effects of this accumulation are discussed. As Al3+ is neurotoxic, the brain metabolism is most interesting. The normal and the lethally toxic brain levels of Al3+ are well documented and differ only by a factor of 3-10. The normal brain uptake of Al3+ is estimated from data on intestinal uptake of Al3+ and brain uptake of radionuclides of similar ions administered intravenously. The uptake is very slow, 1 mg in 36 years, and is consistent with an assumption that Al3+ taken up by the brain cannot be eliminated and is therefore accumulated. The possibility that Al3+ may cause or contribute to some specific diseases, most of them related to aging, is discussed with the proposed metabolic picture in mind.

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Section: General Discussion On Metabolism and Effects Of Al3+mentioning

confidence: 99%

Metabolism and possible health effects of aluminum.

Ganrot¹

1986

Environ Health Perspect

203

150

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“…The investigation of the distribution and excretion of Be in the body started in the 1950s. It is known that the distribution and excretion of Be depend on route of entry, chemical form, size of dose, and experimental animal species (Feldman et al, 1953;Vacher et a!., 1973;Furchner et al, 1973). We have studied the effects of Be in immunological health surveys of workers handling Be alloy (Sakaguchi et al, 1987a).…”

Section: Introductionmentioning

confidence: 98%

Distribution of radioisotopic beryllium in mice after administration by various routes of injection

Sakaguchi

Nakamura

et al. 1993

Journal of Toxicology and Environmental Health

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A 7BeCl2 solution containing 0.5 micrograms Be per mouse was injected subcutaneously, intraperitoneally, intramuscularly, intrathoracically, and intravenously, and distribution was observed for periods up to 1 wk. 7Be was excreted more rapidly following intravenous injection than by the other routes of injection. The amount of Be found in the liver or the spleen was substantial at 1 d after intraperitoneal injection. It increased more in the spleen at 7 d after either intraperitoneal or intrathoracic injection. On the other hand, the amounts of Be stayed almost constant in the kidneys, by the various routes of injection. When injected intrathoracically, the amounts of Be in the heart and the lung were greater than when administered by the other routes of injection. The amounts of Be in the femurs of mice administered by these routes of injection, except with intravenous injection, were greater than in the other organs. The percentage of 7Be in the mineralized bone was 90% of that of 7Be in the femurs when injected intraperitoneally or intrathoracically. However, the ratio of Be in the mineralized bone to that in the bone marrow was 3 to 2. Beryllium had thus a closer affinity for the femurs than for the other organs investigated, with the different modes of administration used. The amount of Be in the entire skeleton was estimated to be substantial. Within the limitations of 1 wk of exposure, the skeleton would appear to be a critical organ. This would suggest that osteosarcomas may occur following administration of Be to laboratory animals for a long-term period.

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Beryllium Hydrogen Phosphate (1:1) 13598‐15‐7

2004

Sax's Dangerous Properties of Industrial Materials

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Compared effects of two beryllium salts (soluble and insoluble): Toxicity and blockade of the reticuloendothelial system

Cited by 22 publications

References 10 publications

Metabolism and possible health effects of aluminum.

Metabolism and possible health effects of aluminum.

Distribution of radioisotopic beryllium in mice after administration by various routes of injection

Beryllium Hydrogen Phosphate (1:1) 13598‐15‐7

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