Comparatives Evaluation of Antifertility Potential of Leaves of Bambusa arudinacea retz. and Ficus racemosa Bark Extracts in Female Albino Rats

Soni, Vishal; Jha, Arvind Kumar; Dwivedi, Jaya; Soni, Priyanka

doi:10.20510/ukjpb/1/i1/91111

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…e histological findings of this study suggest a hypothalamic-pituitary-gonadal axis dysfunction after treatment with the plant extract through a negative feedback mechanism of the gonadotropins FSH and LH as previously explained [43]. In accordance, several plants have been shown to act in a similar fashion [43,[46][47][48][49][50][51][52].…”

Section: Discussionsupporting

confidence: 81%

The Potential of Jatropha variegata Fruits as a Natural Contraceptive: Antifertility Activity and Phytochemical Analysis

Alhaj

Moharram

Al-Maqtari

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Jatropha variegata (family, Euphorbiaceae) is native to Yemen, where it is commonly known as the Ebki shrub. The fruits of the plant are traditionally ingested by local women as a natural method of contraception. This study was undertaken to investigate the phytochemical content of the methanol extract of J. variegata fruits and to evaluate its antifertility potential. Methods. Isolation of the chemical constituents was performed by chromatographic techniques, and the chemical structures of these compounds were identified by spectroscopy. The antifertility activity of the methanol extract was assessed in two experimental rat models to explore both the anti-implantation and the estrogenic/antiestrogenic activities in females. In these models, the number of successful implants, the size of litter, and body/ovary weights were all recorded. The development of ovarian follicles was also monitored via histological staining. Results. Phytochemical work on the fruit extract of J. variegata led to the isolation of two oils (JF1 and JF2) and methyl elaidate. GC-MS analysis of the JF1 oil revealed that the major chemical constituents were fatty acid esters (43.77%), hydrocarbon alkanes (20.65%), and terpenoids (4.65%), while terpenoids (28.8%), fatty acids and their esters, (29.47%), and phytosterol (10.49%) were the major components found in the JF2 oil. The methanol extract of J. variegata fruit exhibited 50% and 93% abortifacient activity at 150 and 300 mg/kg doses, respectively. The extract also showed significant estrogenic activity as evidenced by the increase in rat ovary weight at a dose of 300 mg/kg compared to the control group. Histological analyses further confirmed this estrogenic activity. Conclusions. J. variegata fruits possess an antifertility activity that appeared to result from its antiembryo implantation potential and from its estrogenic activity. The bioactive constituents involved in these activities may need to be further explored and exploited in the pursuit of newer contraceptives.

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Section: Discussionsupporting

confidence: 81%

The Potential of Jatropha variegata Fruits as a Natural Contraceptive: Antifertility Activity and Phytochemical Analysis

Alhaj

Moharram

Al-Maqtari

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…The bark is highly efficacious in threatened abortion and also recommended in urological disorders, diabetes, hiccough, leprosy, skin diseases, asthma and piles. The leaves are good wash for wounds and ulcers 2,3 .…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Medicated Derma Sticks of Ficus racemosa For Management of Infectious Skin Diseases

Murthy¹,

Rao²

2018

PBJ

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External infections involving the skin are the most frequent complications affecting humans and animals. Medicinal plants play great roles in the treatment of infectious skin diseases. The present study was aimed to formulate and evaluate medicated sticks of Ficus racemosa extract. The petroleum ether and ethanol (70%) extracts were prepared. Medicated derma sticks of Ficus racemosa extract were prepared by heating and congealing and evaluated for thickness, length and weight. The findings of weight, thickness and length of medicated derma sticks of Ficus racemosa were found to 2.3±0.18 gm, 5.9±0.32 mm and 3.8±0.11 cm, respectively. The medicated derma sticks of Ficus racemosa were evaluated for antimicrobial activity against S. aureus, E. coli and C. albicans, and further stability studies was performed. The zones of inhibition of medicated derma sticks of Ficus racemosa against S. aureus, E. coli and C. albicans were 20.17±0.31, 18.24±0.82 and 29.12±0.65 mm, respectively. The values of zones of inhibition were near to value of pure drug. The stability study of medicated derma sticks of Ficus racemosa exhibited that the formulations were safe to use.

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Experimental Evaluation of Pippali, Vidanga and Tankana for Contraceptive effect

R. Kadibagil,

Sarashetti

2023

RJPT

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Since centuries women have been target of family planning measure and medicines. But chemical contraceptives are inherently unreliable and interfere with delicate and complex immunologicalreproductive system of women with high risk. This provided an opportunity to the research scholars to explore herbal contraceptive medicine. The concept of contraceptive is not a new to Ayurveda. Various contraceptives are mentioned in classical Ayurvedic texts. Such as 1) Pippali (Piper longum), Vidanga (Emblicaribes) and Tankana (SodiiBiboras). 2) Talisapatra (Taxus baccata) and Gairika (Hematite) with cold water and 3) Kanji (sour gruel) Bhavita(triturated) Japakusuma (Hibiscus rosa sinensis). The herbo mineral combination of Pippali (Piper longum), Vidanga (Emblicaribes) and Tankana (SodiiBiboras) was subjected for anti-implantation activity on albino rats by Choudhary and Khanna's method. Significant difference was noted in number of implantations, in weight of uterus and ovary in study group compared with standard group. Histological reports on isolated ovary reveals that study drug combination was suppressed the maturation of graffian follicle. Pippali, Vidanga and Tankana drug combination shown significant anti- implantation activity in albino rats and given further scope for clinical study which may contribute a better contraceptive medicine to female generation under national mainstream of health programme.

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Comparatives Evaluation of Antifertility Potential of Leaves of Bambusa arudinacea retz. and Ficus racemosa Bark Extracts in Female Albino Rats

Cited by 3 publications

References 2 publications

The Potential of Jatropha variegata Fruits as a Natural Contraceptive: Antifertility Activity and Phytochemical Analysis

The Potential of Jatropha variegata Fruits as a Natural Contraceptive: Antifertility Activity and Phytochemical Analysis

Formulation and Evaluation of Medicated Derma Sticks of Ficus racemosa For Management of Infectious Skin Diseases

Experimental Evaluation of Pippali, Vidanga and Tankana for Contraceptive effect

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