Comparative vitellogenic responses in three teleost species: extrapolation to in situ field studies

Thompson, Steven D.; Tilton, Fred; Schlenk, Daniel; Benson, William H.

doi:10.1016/s0141-1136(00)00077-5

Cited by 53 publications

(21 citation statements)

References 6 publications

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“…The LOEC of E2 for induction of vitellogenin mRNAs was observed at < 0.1 Ag/l (or < 0.1 ppb) in medaka and at < 1 Ag/l (or < 1 ppb) in zebrafish. These ranges are consistent with the previous studies in the two models (Thompson et al, 2000;Brion et al, 2002) as well as in other fish models (Bowman et al, 2000;Denslow et al, 2001).…”

Section: Induction Of Vitellogenin Mrnas In the Zebrafish And Medakasupporting

confidence: 93%

Molecular cloning of zebrafish and medaka vitellogenin genes and comparison of their expression in response to 17β-estradiol

Tong

Shan

Poh

et al. 2004

Gene

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Section: Induction Of Vitellogenin Mrnas In the Zebrafish And Medakasupporting

confidence: 93%

Molecular cloning of zebrafish and medaka vitellogenin genes and comparison of their expression in response to 17β-estradiol

Tong

Shan

Poh

et al. 2004

Gene

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“…Certainly one of these is species differences. Differences have been demonstrated in the responses (both presence or absence and magnitude) of wild fish species collected in the same locations in field monitoring or assessment studies (Kavanagh et al 2004; Vine et al 2005; Baldigo et al 2006; Hinck et al 2009) and among species in more controlled laboratory or experimental pond exposures (Routledge et al 1998; Thompson et al 2000; Van den Belt et al 2003; Palace et al 2009; Yonkos et al 2010). Smallmouth bass, like roach Rutilus rutilis studied extensively in Europe (Jobling et al 1998; Nolan et al 2001; Tyler et al 2007), appears to be a sensitive and potentially important sentinel species for reproductive endocrine disruption studies.…”

Section: Discussionmentioning

confidence: 99%

Reproductive endocrine disruption in smallmouth bass (Micropterus dolomieu) in the Potomac River basin: spatial and temporal comparisons of biological effects

Blazer

Iwanowicz

Henderson

et al. 2011

Environ Monit Assess

118

105

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A high prevalence of intersex or testicular oocytes (TO) in male smallmouth bass within the Potomac River drainage has raised concerns as to the health of the river. Studies were conducted to document biomarker responses both temporally and spatially to better understand the influence of normal physiological cycles, as well as water quality and land-use influences. Smallmouth bass were collected over a 2-year period from three tributaries of the Potomac River: the Shenandoah River, the South Branch Potomac and Conococheague Creek, and an out-of-basin reference site on the Gauley River. The prevalence of TO varied seasonally with the lowest prevalence observed in July, post-spawn. Reproductive maturity and/or lack of spawning the previous spring, as well as land-use practices such as application of manure and pesticides, may influence the seasonal observations. Annual, seasonal, and site differences were also observed in the percentage of males with measurable concentrations of plasma vitellogenin, mean concentration of plasma vitellogenin in females, and plasma concentrations of 17β-estradiol and testosterone in both sexes. Bass collected in the South Branch Potomac (moderate to high prevalence of TO) had less sperm per testes mass with a lower percentage of those sperm being motile when compared to those from the Gauley River (low prevalence of TO). An inverse relationship was noted between TO severity and sperm motility. An association between TO severity and wastewater treatment plant flow, percent of agriculture, total number of animal feeding operations, the number of poultry houses, and animal density within the catchment was observed.

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“…; Thompson et al, 2000). In contrast, due to the relatively low estrogenic activity and limited solubility of NP and BPA, we could not reach the maximum VTG induction plateaus which resulted in no nonlinear regression models fitted to the experimental data well.…”

mentioning

confidence: 80%

Interactions between estrogenic chemicals in binary mixtures investigated using vitellogenin induction and factorial analysis

2009

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a b s t r a c tConsiderable progress has been made in assessing the combined effects of chemicals, but the effect of mixtures remains one of the most daunting challenges in environmental toxicology. In this study, the effects of binary mixtures of estrogenic chemicals were investigated using plasma vitellogenin (VTG) induction in male adult Japanese medaka (Oryzias latipes) as the endpoint. We focused on whether or not the factorial design using rigorous statistical methods was appropriate for the identification of possible interactions. The estrogenic activities of 17b-estradiol (E2), 4-tert-nonylphenol (NP) and bisphenol A (BPA) were investigated in medaka following 14 d of exposure. Although all chemicals induced concentration-dependent increases in plasma VTG, a complete concentration-response curve was obtained only for E2, while partial curves were obtained for NP and BPA. Therefore, a 3Â3 factorial design was employed to identify both the individual and interactive effects. A significant difference in mean plasma VTG induction was found when any chemical was considered alone. However, no significant interactions between E2 and NP, E2 and BPA, and NP and BPA were demonstrated. These results suggest that these three model estrogenic chemicals share a common mechanism for inducing VTG synthesis, and that no interactions occur when they act in combination. We also demonstrated the ability of this experimental design to detect interactions between binary mixtures, which will allow the assessment of biological effects of more complex mixtures in future research.

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Comparative vitellogenic responses in three teleost species: extrapolation to in situ field studies

Cited by 53 publications

References 6 publications

Molecular cloning of zebrafish and medaka vitellogenin genes and comparison of their expression in response to 17β-estradiol

Molecular cloning of zebrafish and medaka vitellogenin genes and comparison of their expression in response to 17β-estradiol

Reproductive endocrine disruption in smallmouth bass (Micropterus dolomieu) in the Potomac River basin: spatial and temporal comparisons of biological effects

Interactions between estrogenic chemicals in binary mixtures investigated using vitellogenin induction and factorial analysis

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