Comparative toxicity of nano-ZnO and bulk ZnO suspensions to zebrafish and the effects of sedimentation, ˙OH production and particle dissolution in distilled water

Li, Yu; Fang, Tao; Xiong, Dao-wen; Zhu, Wentao; Sima, Xiao-Feng

doi:10.1039/c1em10197h

Cited by 90 publications

(52 citation statements)

References 42 publications

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“…The slope (R 2 ) and hazard concentration 5% (with 90% confidence intervals) are indicated. Data from (Adams et al, 2006;Aruoja et al, 2009;Baek and An, 2011;Dasari et al, 2013;Franklin et al, 2007;Heinlaan et al, 2008;Hu et al, 2009;Ivask et al, 2010;Kasemets et al, 2009;Li et al, 2011Li et al, , 2013Ma et al, 2009Ma et al, , 2011Manzo et al, 2013;Mortimer et al, 2010;Nations et al, 2011;Poynton et al, 2011;Wang et al, 2009;Wiench et al, 2009;Xiong et al, 2011;Yu et al, 2011;Zhao et al, 2012;Zhu et al, 2008Zhu et al, , 2009aZhu et al, ,2009b were used for the construction of the SSD. The other invertebrates (for ZnCl 2 ) represent species of sea urchin and protozoa.…”

Section: Effect Of Nanoparticle Dissolution On Ssdmentioning

confidence: 99%

Aquatic acute species sensitivity distributions of ZnO and CuO nanoparticles

Adam

Schmitt

Bruyn

et al. 2015

Science of The Total Environment

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Metal oxide nanoparticles are increasingly being produced and will inevitably end up in the aquatic environment. Up till now, most papers have studied individual nanoparticle effects. However, the implementation of these data into a risk assessment tool, needed to characterise their risk to the aquatic environment, is still largely lacking. Therefore, aquatic species sensitivity distributions (SSDs) were constructed for ZnO and CuO nanoparticles and 5% hazard concentrations (HC5) were calculated in this study. The effect of individual nanoparticles on these SSDs was estimated by comparison with bulk SSDs. Additionally, the effect of nanoparticle dynamics (aggregation and dissolution) was considered by evaluating the effect of aggregate size on the toxicity, by estimation of the dissolved fraction and comparison with SSDs for ZnCl2 and CuCl2 inorganic salt. Bacteria, protozoa, yeast, rotifera, algae, nematoda, crustacea, hexapoda, fish and amphibia species were included in the analysis. The results show that algae (Zn) and crustacea (Zn, Cu) are the most sensitive species when exposed to the chemicals. Similar acute sensitivity distributions were obtained for ZnO nanoparticles (HC5: 0.06 with 90% confidence interval: 0.03-0.15 mg Zn/l; 43 data points), bulk ZnO (HC5: 0.06 with CI: 0.03-0.20 mg Zn/l; 23 dps) and ZnCl2 (HC5: 0.03 with CI: 0.02-0.05 mg Zn/l; 261 dps). CuO nanoparticles (HC5: 0.15 with CI: 0.05-0.47 mg Cu/l; 43 dps) are more toxic than the bulk materials (HC5: 6.19 with CI: 2.15-38.11 mg Cu/l; 12 dps) but less toxic than CuCl2 (HC5: 0.009 with CI: 0.007-0.012 mg Cu/l; 594 dps) to aquatic species. However, the combined dissolution and SSD results indicate that the toxicity of these nanoparticles is mainly caused by dissolved metal ions. Based on the available information, no current risk of these nanoparticles to the aquatic environment is expected.

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Section: Effect Of Nanoparticle Dissolution On Ssdmentioning

confidence: 99%

Aquatic acute species sensitivity distributions of ZnO and CuO nanoparticles

Adam

Schmitt

Bruyn

et al. 2015

Science of The Total Environment

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“…Indeed, Yu et al (2011) andXiong et al (2011) showed that under illumination, at concentrations above 10 mg/L, suspensions of ZnO NPs induced hydroxyl radicals ( OH). At the same time, no hydroxyl radical production was detected in case of bulk ZnO particles.…”

Section: Oxidative Stress and The Related Effects Of Nanoparticlesmentioning

confidence: 99%

Mechanisms of toxic action of Ag, ZnO and CuO nanoparticles to selected ecotoxicological test organisms and mammalian cells in vitro: A comparative review

et al. 2013

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Silver, ZnO and CuO nanoparticles (NPs) are increasingly used as biocides. There is however increasing evidence of their threat to ''non-target'' organisms. In such a context, the understanding of the toxicity mechanisms is crucial for both the design of more efficient nanoantimicrobials, i.e. for ''toxic by design'' and at the same time for the design of nanomaterials that are biologically and/or environmentally benign throughout their life-cycle (safe by design). This review provides a comprehensive and critical literature overview on Ag, ZnO and CuO NPs' toxicity mechanisms on the basis of various environmentally relevant test species and mammalian cells in vitro. In addition, factors modifying the toxic effect of nanoparticles, e.g. impact of the test media, are discussed. Literature analysis revealed three major phenomena driving the toxicity of these nanoparticles: (i) dissolution of nanoparticles, (ii) organismdependent cellular uptake of NPs and (iii) induction of oxidative stress and consequent cellular damages. The emerging information on quantitative structure-activity relationship modeling of nanomaterials' toxic effects and the challenges of extrapolation of laboratory results to the environment are also addressed.

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“…NPs tend to aggregate in the environment and therefore can be eliminated or captured by sedimentation (Zhu et al 2009;Yu et al 2011). Thus it is important to understand the behavior and fate of TiO 2 NPs in aquatic environments in order to elucidate their toxicology.…”

Section: Introductionmentioning

confidence: 99%

Effects of humic acid and ionic strength on TiO2 nanoparticles sublethal toxicity to zebrafish

Fang

Zhang

et al. 2015

Ecotoxicology

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The stability and bioavailability of titanium dioxide nanoparticles (TiO 2 NPs) suspension could be modified by the physicochemical properties of solution. In the present study, the effect of humic acid (HA) and ionic strength (by adding NaCl) on aggregation and sedimentation of TiO 2 NPs suspension were investigated. Accordingly, the sublethal toxicity of TiO 2 NPs suspensions with different HA and NaCl concentrations toward zebrafish (Danio rerio) was evaluated by monitoring the changes of superoxide dismutase, catalase, malonaldehyde and glutathione in gill, liver and intestine. The results showed that the aggregations formation and hydrodynamic diameter of TiO 2 NPs in suspensions are not essential characteristics to decide toxicity. The varied oxidative stress responses detected in gill, liver and intestine derived from different toxicity mechanisms of TiO 2 NPs. Nevertheless, the oxidative stress could be suppressed by the adding of HA and/or the increase of ionic strength, which can decrease the bioavailability of TiO 2 NPs in water. The study suggests that the environmental factors, such as HA and ionic strength, are important for the fate (aggregation and sedimentation) and toxicity of nanomaterials in aquatic environment.

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Comparative toxicity of nano-ZnO and bulk ZnO suspensions to zebrafish and the effects of sedimentation, ˙OH production and particle dissolution in distilled water

Cited by 90 publications

References 42 publications

Aquatic acute species sensitivity distributions of ZnO and CuO nanoparticles

Aquatic acute species sensitivity distributions of ZnO and CuO nanoparticles

Mechanisms of toxic action of Ag, ZnO and CuO nanoparticles to selected ecotoxicological test organisms and mammalian cells in vitro: A comparative review

Effects of humic acid and ionic strength on TiO2 nanoparticles sublethal toxicity to zebrafish

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