Comparative toxicity of low dose tributyltin chloride on serum, liver, lung and kidney following subchronic exposure

Mitra, Sumonto; Gera, Ruchi; Singh, Vikas; Khandelwal, Shashi

doi:10.1016/j.fct.2013.11.031

Cited by 31 publications

(35 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, (Mitra et al, 2014) reported that; reactive oxygen species but not lipid peroxidation content was observed to be significantly elevated both in the tissues and serum after a month of low dose of TBT exposure.…”

Section: Discussionmentioning

confidence: 95%

“…The dosing regimen and the duration selected in the current study was in accordance with the work of (Mitra et al, 2014) who studied the sub chronic toxicity of TBT in rats. He reported that one month exposure to TBT in low doses resulted in loss of cell viability in liver, kidney as well as the lungs.…”

Section: Discussionmentioning

confidence: 99%

“…Group II (Tributyltin-treated group) : each rat in this group received Tributyltin chloride dissolved in corn oil in a dose of 5 mg/kg for 30 days (Mitra et al, 2014). …”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

The effect of Tributyltin on thyroid follicular cells of adult male albino rats and the possible protective role of green tea: a toxicological, histological and biochemical study

Dine

Nabil

Dwedar

2017

Egypt J Forensic Sci

View full text Add to dashboard Cite

IntroductionTributyltin is one of the important and wide-spread persistent organic contaminants that accumulate in the food chain. It is suspected to cause endocrine-disrupting effects in mammals, due in part to its possible transfer through marine food chains and to the consumption of contaminated seafood.Aim of the workWas to study the possible toxic effect of Tributyltin on thyroid follicular cells of adult male albino rats and to evaluate the possible protective role of green tea.Material and methodsForty-five adult male albino rats were included and randomly divided into 3 equal groups: a control group (Group I); Group II: received tributyltin chloride (TBT) dissolved in corn oil orally in a dose of 5 mg/kg for 30 days. Group III: received tributyltin chloride in the same dose with concomitant oral administration of green tea extract for 30 days. At the end of the experiment, the animals were sacrificed and blood samples were subjected to hormonal assay for T3, T4 and TSH levels. Malondialdehyde and reduced glutathione were assessed. The thyroid tissue was processed for histological and ultrastructure examination. The colloid area of thyroid follicles was evaluated morphometrically and statistically analyzed.ResultsA significant decrease in T3 and T4 levels and serum reduced glutathione in the group II when compared with the other groups. Furthermore, a significant increase in serum Malondialdehyde and TSH levels was recorded in group II treated group by comparison to the other two groups. Histopathological and ultrastructural changes of thyroid gland follicles were detected in tributyltin treated rats; the follicular cells appeared swollen and vacuolated. Epithelial stratification was noticed in some foci with excessive vacuolation of the colloid. Dilated rough endoplasmic reticulum filled with flocculent material and increased number of lysosomes were also detected together with variation in shape and size of the nuclei. A marked improvement in the histological features of thyroid follicles was noticed in group III.ConclusionTributyltin induces oxidative stress in rats as well as anti-thyroid effect. The green tea extract is useful in combating tissue injury that is a result of tributyltin toxicity.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of Tributyltin on thyroid follicular cells of adult male albino rats and the possible protective role of green tea: a toxicological, histological and biochemical study

Dine

Nabil

Dwedar

2017

Egypt J Forensic Sci

View full text Add to dashboard Cite

show abstract

“…In mammals, TBT is toxic to a number of organs [8][9][10]. Recently, TBT was shown to affect adipogenic differentiation by activating peroxisome proliferatoractivated receptor (PPAR) γ and retinoid X receptor (RXR) in vitro [11].…”

Section: Reverse-transcriptional Real-time Pcr (Rt-pcr)mentioning

confidence: 99%

Wpływ tributylocyny na przyjmowanie pokarmu i ekspresję neuropeptydów w mózgu szczurów

Zhang

Chen

2015

Endokrynologia Polska

View full text Add to dashboard Cite

Introduction: Tributyltin (TBT) is a largely diffused environmental pollutant. Several studies have demonstrated that TBT is involved in the development of obesity. However, few studies addressing the effects of TBT on the brain neuropeptides involved in appetite and body weight homeostasis have been published. Material and methods: Experiments were carried out on female and male Sprague-Dawley rats. Animals were exposed to TBT (0.5 μg/kg body weight) for 54 days. The hepatic triglyceride and total cholesterol were determined using commercial enzyme kits. The NPY, AgRP, POMC and CART mRNA expression in brains were quantified by real-time PCR. Results: TBT exposure resulted in significant increases in the hepatic total cholesterol and triglyceride concentration of both male and female rats. Interestingly, increases in body weight and fat mass were only found in the TBT-treated male rats. TBT exposure also led to a significant increase in food intake by the female rats, while no change was observed in the male rats. Moreover, the neuropeptides expression was different between males and females after TBT exposure. TBT induced brain NPY expression in the female rats, and depressed brain POMC, AgRP and CART expression in the males. Conclusions: TBT can increase food intake in female rats, which is associated with the disturbance of NPY in brains. TBT had sex-different effects on brain NPY, AgRP, POMC and CART mRNA expression, which indicates a complex neuroendocrine mechanism of TBT.

show abstract

“…) Além disso, o TBT é classificado como um produto químico desregulador endócrino (EDC), obesogênico, sendo capaz de intensificar processos metabólicos por atuar como programador metabólico, aumentando o risco de obesidade e outras anormalidades metabólicas. (FARINETTI et al, 2018;GRACELI et al, 2013) Os efeitos tóxicos da exposição ao TBT são descritos em vários sistemas tais como: metabolismo anormal de hormônios sexuais em roedores, (GIBSON e Wilson, 2003;GRÜN et al, 2006) síndrome metabólica e adipogênese ovariana anormal em ratas, (IMO, 2001) disfunções reprodutivas, irregularidade do ciclo estral, danos morfológicos nos ovários de ratas, (IPCS, 1999;JANESICK e Blumberg, 2011;KISHTA et al, 2007) inibição da função mitocondrial, (KRAJNC et al, 1984) imunidade dependente do timo, (LANG et al, 2012), mudanças no metabolismo do heme (LIU e Peterson, 2015;MAGUIRE, 1987 , 1980;MITRA et al, 2014;OMURA et al, 2001;PALMER et al, 2006) Nosso estudo anterior demonstrou que a cardiotoxicidade aguda do TBT, está presente, mesmo em baixas doses, danificando a contratilidade e o relaxamento…”

unclassified

Dilemas Bioéticos, Espiritualidade, Formação Profissional E a Inter-Relação Com Paciente

Assis¹,

Santos²,

Vieira³

et al. 2020

Ações De Saúde E Geração De Conhecimento Nas Ciências Médicas

View full text Add to dashboard Cite

Comparative toxicity of low dose tributyltin chloride on serum, liver, lung and kidney following subchronic exposure

Cited by 31 publications

References 46 publications

The effect of Tributyltin on thyroid follicular cells of adult male albino rats and the possible protective role of green tea: a toxicological, histological and biochemical study

The effect of Tributyltin on thyroid follicular cells of adult male albino rats and the possible protective role of green tea: a toxicological, histological and biochemical study

Wpływ tributylocyny na przyjmowanie pokarmu i ekspresję neuropeptydów w mózgu szczurów

Dilemas Bioéticos, Espiritualidade, Formação Profissional E a Inter-Relação Com Paciente

Contact Info

Product

Resources

About