Comparative Toxicity of Intraocular Irrigating Solutions on the Corneal Endothelium

Edelhauser, Henry F.; Horn, Diane L. Van; Schultz, Richard O.; Hyndiuk, Robert A.

doi:10.1016/0002-9394(76)90304-4

Cited by 109 publications

(48 citation statements)

References 3 publications

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“…The aetiology of TASS is relatively broad and may include problems involving irrigating solutions, such as Balanced Saline Solution (BSS) and any additives included. [5][6][7][8][9] Highest number of cases of PCO were in patients with non-square edge lenses as compared to square edge lens and foldable lens. The reason for low incidence of PCO in square edge and foldable lenses is because of the unique IOL design.…”

Section: Resultsmentioning

confidence: 99%

Development of Posterior Capsular Opacification Post-Operatively in Cataract Surgery Using Different Techniques and Different Intraocular Lenses

Javadekar¹

2017

jemds

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BACKGROUNDWith accurate estimation of power of Intraocular Lens (IOL), uncomplicated cataract surgery and uneventful post-operative period, the implant is capable of providing a visual acuity of 6/6 and a normal field of vision. However, post-operative results are not always according to the expectations. Among all the causes of subnormal vision, Posterior Capsular Opacification (PCO) is one of the common cause of subnormal vision postoperatively. This study is an attempt to find out causes of posterior capsular opacification in an uneventful cataract surgery with posterior chamber intraocular lens by various surgical techniques and using different intraocular lenses in Krishna Institute of Medical Sciences, Karad and Prakash Institute of Medical Science and Research, Islampur.The aims of this study are to study the incidence of posterior capsular opacification in patients who have undergone uneventful cataract surgery with posterior chamber IOL implant and relation between the type of surgery and IOL used and its effect on the subnormal vision post-operatively due to posterior capsular opacification, also to find out other causes of subnormal vision 6 weeks post-operatively in an uneventful cataract surgery in Krishna Hospital over a period of 13 months and in Prakash Institute of Medical Science and Research, Islampur over a period of 5 months

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Section: Resultsmentioning

confidence: 99%

Development of Posterior Capsular Opacification Post-Operatively in Cataract Surgery Using Different Techniques and Different Intraocular Lenses

Javadekar¹

2017

jemds

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“…Hatta intraoküler yapılar üzerine toksik etkileri olabileceği gösterilmiştir. Edel Hauser ve arkadaşları yaptıkları bir çalışmada izotonik salin solüsyo-nunun intraoküler uygulamada 1 saat içerisinde endotel hasarı oluşturduğunu göstermişlerdir (10,11). Nazal mukozal lavaj uygulamaları da Ringer laktat solüsyonunun, izotonik salin (%0,9 NaCl) solüsyonuna göre siliyer yapıdaki epiteli koruduğu ve siliyer aktiviteyi bozmadığını göster-miştir (1).…”

Section: Discussionunclassified

Farklı Lavaj Solüsyonlarının Akut Akciğer Hasarı Oluşumundaki Etkilerinin Araştırılması

Gündoğdu¹,

Özcan²,

Telci³

et al. 2011

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Amaç: Çeşitli çalışmalarda Ringer laktat solüsyonunun izotonik salin (%0,9 NaCl) solüsyona oranla üst hava yollarında, mukosiliyer aktivite ve klirens üzerinde koruyucu etkilerinin olduğu göste-rilmiştir. Çalışmamızda canlı dokularda irrigasyon için daha uygun olarak gösterilen Ringer laktat solüsyonunun izotonik salin solüs-yona göre akciğer hasarına etkisini araştırmayı hedefledik. Gereç ve Yöntem: İstanbul Üniversitesi, İstanbul Tıp Fakültesi Deneysel Hayvan Araştırmaları Enstitüsü Etik Kurulu onayı alın-dıktan sonra toplam 24 adet 250-300 g ağırlığında SpragueDawley türü sıçan anestezi altında trakeostomize edilmiştir. Sıçanlar basınç kontrollü ventilasyon modunda ventile edilmiştir. Çalışmamızın ilk bölümünde Ringer laktat ve izotonik salin solüs-yonları ile ARDS oluşturan lavaj miktarının bulunması amaçlan-mıştır. Çalışmamızın ikinci bölümünde erken ARDS oluşturduğu belirlenen miktarda sıvı kullanılarak iki farklı gruba ayrılan deneklerde inceleme yapılmıştır. Deneklerin akciğer hasarı akciğer yaş/kuru ağırlıkları, BAL'da mikroalbümin düzeyi ve arter kan gazı değişiklikleri ile değerlendirilmiştir. Bulgular: Beklediğimizin aksine izotonik salin ile ortalama 11,4 adet lavajla ARDS oluşurken Ringer laktat ile 10,57 adet lavajla ARDS gelişmiştir. Çalışmamızın ikinci bölümünde her iki solüsyon-la 10'ar adet lavaj uygulanmış, yaş/kuru ağırlık ve BAL'da miroalbümin düzeyleri istatistiksel olarak anlamlı olmasa da izotonik lavaj grubunda düşük bulunmuştur. ÖZET SUMMARYAim: Experimental animal studies showed that lactated Ringer solution have beneficial effects over isotonic saline solution (0.9% NaCl) for mucociliar activity and clearance of upper respiratory tract. In this study we evaluated the effect of lactated Ringer solution and isotonic saline solution on rat lungs for lung injury. Material and Method: Istanbul University, Istanbul Medical Faculty, Experimental Animal Researches Study Institute ethical committee approval was obtained for 24 Sprague-Dawley rats each weighing between 250-300 g. Rats were tracheostomized under general anesthesia and ventilated using pressure controlled ventilation mode. As the first part of our study, we aimed to find the adequate lavage volume of isotonic saline and lactated Ringer solutions to induce ARDS. After finding the adequate lavage volume and count; the mean lavage count that induce ARDS, rest of the rats were randomly divided into two groups and tracheal lavages were performed according to predetermined lavage volume and count in the second part of the study. Wet/dry body weight counts, arterial blood gas sampling and microalbumin levels of bronchoalveolar lavage were analyzed for assessment of lung injury. Results: ARDS was developed following 11.4 lavages with isotonic saline solution and 10.57 lavages with lactated Ringer solutions. In the second part of the study, wet/dry body weight and BAL microalbumin levels were found lower in isotonic saline group however the difference between groups were not statistically significant. Conclusion:We were not able to demo...

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“…Perfusion fluids should not be toxic to the corneal endothelium, as the use of an unphysiological solution is likely to potentiate any mechanical disruption of the endothelium during the surgical manipulation. A suitable artificial aqueous for prolonged perfusion has been shown by Edelhauser et al (1976) to require a bicarbonated Ringer's solution with added glucose, glutathione, and adenosine (GBR). The same authors suggest that for low volume irrigation of the anterior chamber less favourable fluids such as sodium chloride 09 % or Ringer-lactate solution might be adequate.…”

Section: Discussionmentioning

confidence: 99%

Effects of intraocular miotics on cultured bovine corneal endothelium.

Jay¹,

MacDonald²

1978

British Journal of Ophthalmology

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Experiments were set up to study the morphological changes induced in bovine corneal endothelial cell culutures in vitro after a brief exposure to various miotic preparations. The relative toxic effects of pH, osmolality, absence of calcium, or presence of pilocarpine were investigated. The probable cause of the corneal oedema noted in the 2 clinical cases included in this report was identified, and the minimum requirements for the formulation of a miotic solution for intraocular use are outlined. Case reports CASE IAn apparently uncomplicated intracapsular cryoextraction for presenile nuclear cataract was performed on a 51-year-old woman. Preoperative examination of the cornea by specular reflection with the slit-lamp microscope hiad shown slight

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Comparative Toxicity of Intraocular Irrigating Solutions on the Corneal Endothelium

Cited by 109 publications

References 3 publications

Development of Posterior Capsular Opacification Post-Operatively in Cataract Surgery Using Different Techniques and Different Intraocular Lenses

Development of Posterior Capsular Opacification Post-Operatively in Cataract Surgery Using Different Techniques and Different Intraocular Lenses

Farklı Lavaj Solüsyonlarının Akut Akciğer Hasarı Oluşumundaki Etkilerinin Araştırılması

Effects of intraocular miotics on cultured bovine corneal endothelium.

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