Comparative Toxicities of Hydrastis Canadensis L., Berberis aristata DC. and Achillea millefolium L. Against Brine Shrimps (Artemia salina) Using Dosage Mortality Curve: A Probit Approach

Karim, Mahwish Ahmed; Rizwani, Ghazala H.; Sidddiqui, Afaq Ahmed; Khan, Muhammad Farhanullah

doi:10.6000/1927-5129.2015.11.09

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…With the exception of the mentioned extracts, a significant mortality rate (more than 50% after 48 h), was showed the EA of A. grandifolia and ET of A. abrotanoides (LC50 values of 676.08 and 712.85 μg/mL, respectively). Examination of the toxicity of extracts of A. millefolium toward the nauplii of A. salina was the subject of other studies [33,34]. The acute toxicity of the chloroform extract of A. millefolium was proven [33], which is in agreement with our results.…”

Section: Table IVsupporting

confidence: 90%

Phytochemical Investigation, Acute Toxicity, Antioxidant and Antidiabetic Activity of Extracts From Aerial Parts of Four Wild Growing Achillea Species

RISTIĆ

2023

FARMACIA

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Plants from the genus Achillea are rich in biologically active ingredients and are traditionally known for their healing potential. In this research, the phytochemical profile was investigated, the content of total phenolics and flavonoids was determined and examined the acute toxicity, antioxidant and antidiabetic activity of ethanolic, ethyl acetate and chloroform extracts of Achillea abrotanoides (Vis.) Vis., Achillea chrysocoma Friv., Achillea grandifolia Friv. and Achillea millefolium L. Tested extracts showed the presence of different groups of phytochemicals, while the high content of total phenolics and flavonoids was quantified, especially in the ethanolic and ethyl acetate extracts. The acute toxicity was examined in the Artemia salina model, where the extracts did not show significant toxicity after an incubation period of 24 hours, while after 48 hours, strong acute toxicity was recorded in chloroform extracts of A. millefolium and A. chrysocoma. Extracts were tested for antioxidant activity using the DPPH test, as well as antidiabetic activity based on their ability to inhibit the α-amylase. Ethanol and ethyl acetate extracts of A. abrotanoides and A. millefolium showed a great ability to reduce DPPH radicals, while the same extracts accomplished a significant inhibitory potential on α-amylase. Also, a correlation was established between the content of total phenolics and flavonoids with the antioxidant activity of the extracts. RezumatPlantele din genul Achillea, bogate în principii biologic active, sunt cunoscute în mod tradițional pentru potențialul lor curativ. În cadrul acestui studiu, au fost caracterizate fitochimic și evaluate din punct de vedere al toxicității acute, al acțiunii antioxidante și al activității antidiabetice extractele etanolice, de acetat de etil și de cloroform ale speciilor Achillea abrotanoides (Vis.) Vis., Achillea chrysocoma Friv., Achillea grandifolia Friv. și Achillea millefolium L. Toxicitatea acută a fost examinată pe modelul Artemia salina, unde extractele nu au prezentat o toxicitate semnificativă după 24 de ore, în timp ce după 48 de ore, s-au observat efecte toxice marcante pentru extractele cloroformice de A. millefolium și A. chrysocoma. Extractele au fost testate pentru activitatea antioxidantă folosind-se testul DPPH, precum și pentru activitatea antidiabetică bazată pe capacitatea lor de a inhiba α-amilaza. Extractele de etanol și de acetat de etil din A. abrotanoides și A. millefolium au demonstrat o mare capacitate de reducere a radicalilor DPPH, în timp ce aceleași extracte au realizat un potențial inhibitor semnificativ asupra α-amilazei. De asemenea, s-a stabilit o corelație între conținutul în fenoli totali și flavonoide și activitatea antioxidantă a extractelor.

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Section: Table IVsupporting

confidence: 90%

Phytochemical Investigation, Acute Toxicity, Antioxidant and Antidiabetic Activity of Extracts From Aerial Parts of Four Wild Growing Achillea Species

RISTIĆ

2023

FARMACIA

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Phytotherapy of Hypertension: An Updated Overview

Ajebli

Eddouks

2020

EMIDDT

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Background: Cardiovascular disorders are the leading cause of morbidity and mortality throughout the globe. Hypertension is the main risk factor that contributes to the development of many diseases. The use of herbal therapies, medicinal plants and their derivatives for remedying and managing hypertension is well recognized and popular among a wide part of the world population. Methods: The aim of the current review was to collect, treat, and critically analyze the published research relative to experimental and clinical investigations which have studied the blood pressure lowering abilities of medicinal plant derivatives in the last decade. This review was organized into three principal axes; the first axis was attributed to the in vivo and in vitro experimental studies; the second treated the clinical trials; while, the last one is devoted to analyze the mechanisms of action underlying the therapeutic antihypertensive effectiveness of phytochemicals. Results: Different types of extracts and isolated molecules obtained from a large variety of species demonstrated their efficiency in improving raise of blood pressure either experimentally or clinically. Medicinal species such as garlic (Allium sativum), celery (Apium graveolens), Black Cumin (Nigella sativa) and Ginseng (Panax) are among the most common and therapeutically used plant derivatives for controlling hypertension while Asteraceae, Apiaceae and Rosaceae are among the botanical families which were frequently studied in the last decade. Whereas, isolated compounds such as allicin and apigenin have received more interest in this field. Recent evidence from clinical trials suggests that a wide variety of herbal preparations and plant extracts or natural isolated compounds have a favorable therapeutic impact on blood flow. Interestingly, phytochemicals can either act directly on blood vessels via a vasorelaxant effect involving a variety of signaling cascades or indirectly through inhibiting or stimulating a diversity of systems such as angiotensin converting enzyme (ACE), renin angiotensin system (RAS) or the diuretic activity. Hence, based on the findings of the present review medicinal plant derivatives could be used as preventive and curative agents in the case of cardiovascular disorders, particularly hypertension and could play a promoting function for the discovery of new antihypertensive agents. Conclusion: In conclusion, the analysis of the published data shows that a great effort remains to be done to investigate the medicinal plants cited as antihypertensive through published ethnopharmacological surveys. The analysis of the literature in this field shows the lack of standardization at the level of experimental study methods as well as the need to study purified molecules. Moreover the mechanistic studies when they exist remain in the whole partial. On the other hand few advanced clinical studies have been conducted. Finally the determination of the efficacy/safety ratio remains absent in almost all studies.

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Comparative Toxicities of Hydrastis Canadensis L., Berberis aristata DC. and Achillea millefolium L. Against Brine Shrimps (Artemia salina) Using Dosage Mortality Curve: A Probit Approach

Cited by 2 publications

References 11 publications

Phytochemical Investigation, Acute Toxicity, Antioxidant and Antidiabetic Activity of Extracts From Aerial Parts of Four Wild Growing Achillea Species

Phytochemical Investigation, Acute Toxicity, Antioxidant and Antidiabetic Activity of Extracts From Aerial Parts of Four Wild Growing Achillea Species

Phytotherapy of Hypertension: An Updated Overview

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