Comparative tissue distribution and depuration characteristics of copper nanoparticles and soluble copper in rainbow trout (Oncorhynchus mykiss)

Abstract

The continuously growing number of products containing nanoparticles (NPs) makes their presence in the environment inevitable, and given the well‐known toxicity of dissolved metals, concerns regarding the toxicity of metal‐based NPs have been raised. Whether metal‐based NPs present similar or different toxicological effects compared with metal salts is an emerging field. In the present study, rainbow trout were intraperitoneally injected with CuSO4 or copper NPs (CuNPs) to investigate tissue distribution and depuration characteristics. Fish injected with Cu showed an initial accumulation of Cu in the liver, kidney, gills, intestine, and carcass. The Cu concentration in the liver of CuNP‐injected fish increased over time. It appears as though CuNPs accumulated in the liver at a greater rate than they were excreted. In livers of fish injected with CuSO4, the Cu concentration appeared to increase and reach an equilibrium, suggesting that copper was accumulated and excreted at the same rate. The possibility that CuNPs can accumulate at a higher rate than it is excreted in the liver warrants further investigation. The present study demonstrates the possibility of dietary uptake of CuNPs because elevated Cu concentrations were observed in carcass, gills, kidney, and intestine of fish gavaged with CuNPs. In conclusion, the results suggest that dietary CuNPs are taken up by the gut and preferentially accumulate in the liver. Environ Toxicol Chem 2019;38:80–89. © 2018 SETAC

Impacts of trace metals on African common toad, Amietophrynus regularis (Reuss, 1833) and depuration effects of the toad's enteric parasite, Amplicaecum africanum (Taylor, 1924) sampled within Lagos metropolis, Nigeria

“…Isibor and Imoobe (2017b) also detected the preference of copper for the intestinal tissues of Clarias gariepinus and Tilapia mariae. The observations also corroborate the report of Lindh et al (2018) on the comparative tissue distribution and depuration of copper in rainbow trouts. Although copper is an essential metal, it can be toxic to biota at levels elevated above the ecological background levels (Suedel et al, 1994;Song et al, 2015;Xiao et al, 2015;Lindh et al, 2018).…”

Heavy Metal Resistance Determinants of the Foodborne Pathogen Listeria monocytogenes

“…In the environment, metals are typically found at low levels, but their concentrations can increase due to various anthropogenic interventions, including industrial pollution or agricultural practices [9,10]. In an animal host, metal concentrations are dependent on various factors, such as diet and tissue type [11,12,13]. The immune system can utilize metals in response to pathogens, either by restricting metal availability or by accumulating metals, to exert toxic effects on pathogens in the course of an infection [14,15,16].…”

The Single and Combined Effects of Wildfire Runoff and Sediment‐Bound Copper on the Freshwater Amphipod Hyalella azteca

“…Copper analysis was performed as described by Lindh et al (2019). Supernatant was analyzed on an Agilent 240 FS atomic absorption spectrometer with a GTA 120 graphite tube atomizer (Agilent Technologies).…”