Comparative Systemic Toxicity of Convulsant and Supraconvulsant Doses of Intravenous Ropivacaine, Bupivacaine, and Lidocaine in the Conscious Dog

Feldman, Hal S.; Arthur, G. R.; Covino, Benjamín G.

doi:10.1213/00000539-198912000-00019

Cited by 227 publications

(143 citation statements)

References 0 publications

Supporting

Mentioning

125

Contrasting

Unclassified

Order By: Relevance

“…The aetiology of this arrhythmia remains unknown, but a local anaesthetic effect cannot be excluded. Animal and volunteer data support the wider safety margin of ropivacaine compared with racemic bupivacaine, but it is not known whether equipotent doses of ropivacaine are safer than the mixture of lignocaine and racemic bupivacaine or a mixture of lignocaine and S(¹) bupivacaine [5,16]. Recent animal work has suggested that the addition of lignocaine to racemic bupivacaine increases the ventricular fibrillation threshold and attenuates any conduction abnormality induced by bupivacaine [17].…”

Section: Discussionmentioning

confidence: 99%

A comparison of 1% ropivacaine with a mixture of 0.75% bupivacaine and 2% lignocaine for peribulbar anaesthesia

McLure¹,

Rubin²,

Westcott

et al. 1999

Anaesthesia

View full text Add to dashboard Cite

SummaryIn a single centre, randomised, double-blind study, 54 patients underwent intraocular surgery under peribulbar anaesthesia with either ropivacaine 1% or a mixture of bupivacaine 0.75% and lignocaine 2%, both with hyaluronidase 7.5 iu.ml ¹1 . There were no significant differences in volume of anaesthetic required, time to onset of block, peri-operative pain scores or frequency of adverse events between the ropivacaine group and the lignocaine and bupivacaine group.

show abstract

Section: Discussionmentioning

confidence: 99%

A comparison of 1% ropivacaine with a mixture of 0.75% bupivacaine and 2% lignocaine for peribulbar anaesthesia

McLure¹,

Rubin²,

Westcott

et al. 1999

Anaesthesia

View full text Add to dashboard Cite

show abstract

“…However, it is well described that bupivacaineinduced cardiotoxicity occurs in closer relationship to neurological signs than is the case with other local anaesthetic agents. 12,18 The recommendations for commencement of lipid emulsion therapy by Weinberg ( Figure 2) 8 and the Association of Anaesthetists of Great Britain and Ireland (AAGBI) ( Figure 3) 49 are as follows: 1. Commence therapy at the first signs of local anaestheticinduced cardiotoxicity.…”

Section: Reviewmentioning

confidence: 99%

Lipid rescue: the use of lipid emulsions to treat local anaesthetic toxicity

Kruger

Marwick

Levin

2009

Southern African Journal of Anaesthesia and Analgesia

View full text Add to dashboard Cite

“…One of the drawbacks of ropivacaine mentioned is its less intense motor blockade compared to bupivacaine. [8] Hence here is an attempt through the study to compare bupivacaine with ropivacaine in supraclavicular brachial plexus block (subclavian perivascular approach only) [9]. This study is designed to compare 30 ml of bupivacaine 0.5 % and 30 ml of ropivacaine 0.5 % for supraclavicular brachial plexus block by perivascular approach.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of Bupivacaine 0.5% versus Ropivacaine 0.5% for supraclavicular brachial plexus block (subclavian perivascular approach only) in ASA II,III patients

Pooranan

Dhanasekaran

2016

Int J of Adv in Sci Res

View full text Add to dashboard Cite

Introduction: Peripheral nerve blocks have become important in clinical practice because of their role in post-operative pain relief, shortening of patient recovery time & avoiding risks and adverse effects of general anaesthesia. Bupivacaine is a long acting local anaesthetic. Due to its long duration of action and combined with its high quality sensory blockade compared to motor blockade it has been the most commonly used local anaesthetic for peripheral nerve blocks. Ropivacaine is a newer, long acting local anaesthetic whose neuronal blocking potential used in peripheral nerve blockade seems to be equal or superior to bupivacaine. Method of collection of data: Sixty patients aged between 18 years and 60 years, of physical status ASA grade 2 and ASA grade 3 undergoing elective upper limb surgeries lasting more than 30 minutes were included in the study after getting ethical clearance. Each patient was randomly allocated to one of the two groups of 30 patients each. The patients were explained about the procedure and premedicated with tab alprazolam 0.5mg, and tab ranitidine 150 mg. The anesthetic technique employed was supraclavicular brachial plexus block using 30 ml of either 0.5% bupivacaine or 0.5% ropivacaine. Results: In our study, we observed that onset time of sensory block was earlier in bupivacaine group in comparison with ropivacaine group. Onset time of motor block was earlier in bupivacaine group in comparison with ropivacaine group having a mean value of 22.90±1.88 minutes which is statistically significant. Duration of sensory block was 362.00±47.66 minutes with bupivacaine group and 322.00±42.38 minutes with ropivacaine group. The duration of sensory block was longer in bupivaine group compared with ropivacaine group. The duration of motor block was 399.00±41.05 minutes with bupivacaine group and 366.00±37.29 minutes with ropivacaine group. The duration of motor block was longer in bupivaine group compared with ropivacaine group. The duration of analgesia was 402.00±42.86 minutes with bupivacaine group (Group B) and 371.00±36.52 minutes with ropivacaine group (Group R) in our study. Conclusion: On the basis of our study, we can draw the conclusion that at equal volumes bupivacaine 0.5% has an advantage over ropivacaine 0.5% for supraclavicular brachial plexus block in terms of early onset of sensory blockade, early onset of motor blockade, prolonged duration of sensory blockade, prolonged duration of motor blockade, prolonged duration of analgesia.

show abstract

Comparative Systemic Toxicity of Convulsant and Supraconvulsant Doses of Intravenous Ropivacaine, Bupivacaine, and Lidocaine in the Conscious Dog

Cited by 227 publications

References 0 publications

A comparison of 1% ropivacaine with a mixture of 0.75% bupivacaine and 2% lignocaine for peribulbar anaesthesia

A comparison of 1% ropivacaine with a mixture of 0.75% bupivacaine and 2% lignocaine for peribulbar anaesthesia

Lipid rescue: the use of lipid emulsions to treat local anaesthetic toxicity

A comparative study of Bupivacaine 0.5% versus Ropivacaine 0.5% for supraclavicular brachial plexus block (subclavian perivascular approach only) in ASA II,III patients

Contact Info

Product

Resources

About