1987
DOI: 10.1128/aac.31.6.949
|View full text |Cite
|
Sign up to set email alerts
|

Comparative susceptibilities of Campylobacter pylori to norfloxacin and other agents

Abstract: Twenty-one strains of Campylobacter pylori (Campylobacter pyloridis) were tested for susceptibility to norfloxacin and other agents by the serial agar dilution method. Ampicillin (MIC for 90% of isolates [MIC901, 0.016 ,ug/ml) and famotidine (MIC90, >1,024 ,ug/ml) were, respectively, the most and the least active of the agents tested. Norfloxacin (MICg, 1 p,g/ml) and imipenem (MIC90, 0.125 p,g/ml) were substantially active against this organism.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
9
0

Year Published

1988
1988
1993
1993

Publication Types

Select...
6
3

Relationship

0
9

Authors

Journals

citations
Cited by 22 publications
(10 citation statements)
references
References 10 publications
1
9
0
Order By: Relevance
“…Bismuth citrate was active against all of the strains tested, and these MICs agree well with those previously reported by several investigators (8,22,36). Cimetidine, ranitidine, and famotidine were almost inactive, and these results are also in agreement with those reported elsewhere (8,32). In contrast to these histamine H2 receptor antagonists, two proton pump inhibitors, omeprazole and lansoprazole, showed considerable activities.…”
Section: Resultssupporting
confidence: 81%
See 1 more Smart Citation
“…Bismuth citrate was active against all of the strains tested, and these MICs agree well with those previously reported by several investigators (8,22,36). Cimetidine, ranitidine, and famotidine were almost inactive, and these results are also in agreement with those reported elsewhere (8,32). In contrast to these histamine H2 receptor antagonists, two proton pump inhibitors, omeprazole and lansoprazole, showed considerable activities.…”
Section: Resultssupporting
confidence: 81%
“…In vitro, a number of antibiotics, including P-lactams, macrolides, and quinolones, have been known to be highly active against H. pylori (1,8,10,13,22,30,32,33,36). However, when tested as single agents in clinical studies, erythromycin (23), doxycycline (35), ofloxacin (5), ciprofloxacin (34), and norfloxacin (24) have not succeeded in eradicating H. pylori.…”
Section: Resultsmentioning
confidence: 99%
“…venerealis, and C. hyointestinalis, for which MICs are 128 to 256 pug/ml (48). One of us found C. pylori strains to be resistant to intermediate levels of nalidixic acid (MIC, 48 ,ug/ml) (46), although others (36) have noted a wider range of susceptibilities (MIC, 4 to 128 ,ug/ml). In vitro activities of the fluoroquinolones against Campylobacter species have been reported by a number of workers (8,12,13,36).…”
Section: Quinolone Resistancementioning
confidence: 99%
“…pylori is susceptible to amoxicillin, ampicillin, carbenicillin, cefamandole, cefoxitin, cephalothin, cephradine, chloramphenicol, ciprofloxacin, clindamycin, clorobiocin, CP 62993, doxycycline, erythromycin, gentamicin, imipenem, kanamycin, minocycline, nifuroxazide, nitrofurantoin, norfloxacin, ofloxacin, oxolinic acid, rifampin, roxithromycin, tetracycline, and tobramycin (2,10,16,36,57,78,80,86,117,123,128). Most isolates are resistant to colistin, nalidixic acid, trimethoprim, sulfonamides, vancomycin, and polymyxin B (10,57,78,80,117,123), and some are resistant to cefaclor, metronidazole, and penicillin (78,86,128). Since drugs such as cimetidine and bismuth compounds have been used for treating gastric disease for a number of years, there has been significant interest in examining the in vitro activity of these agents against C. pylori.…”
Section: Gastric Diseasesmentioning
confidence: 99%