Comparative survival following different treatment modalities for stage T2 bladder cancer in octogenarians

Trulson, Jerry; Haden, Tyler; Kheterpal, Emil; Pokala, Naveen

doi:10.1007/s00345-013-1123-2

Cited by 12 publications

(5 citation statements)

References 16 publications

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“…To date, assessing the prognosis of patients with MIBC is mainly based on tumor-related factors. Extravesical tumor stage (pT3-4), lymph node metastasis, and nonurothelial variant histology have been established as poor prognostic factors for patients treated with RC [4][5][6][7][8] survival after RC, therapeutic decision-making after RC for BUC remains a major challenge [9,10]. Therefore, identifying new biological markers for determining the risk of poor prognosis is important for designing treatment strategies for patients with BUC.…”

Section: Introductionmentioning

confidence: 99%

The prognostic role of preoperative serum albumin/globulin ratio in patients with bladder urothelial carcinoma undergoing radical cystectomy

Liu

Dai

Zhou

et al. 2016

Urologic Oncology: Seminars and Original Investigations

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Section: Introductionmentioning

confidence: 99%

The prognostic role of preoperative serum albumin/globulin ratio in patients with bladder urothelial carcinoma undergoing radical cystectomy

Liu

Dai

Zhou

et al. 2016

Urologic Oncology: Seminars and Original Investigations

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“…Seven patients eventually underwent salvage radical cystectomy and in patients requiring radical cystectomy, the OS was significantly higher at 24 vs. 10 months than in TURBT [21 ▪ ]. Previous comparative series in patients greater than 80 years old likewise had mixed results: some studies report significantly decreased OS for TURBT (9 vs. 28 months [22], 14 vs. 39 months [23]) whereas others found no survival benefit of radical cystectomy over TURBT [24,25].…”

Section: Bladder Cancermentioning

confidence: 92%

“…Carrion ]. Previous comparative series in patients greater than 80 years old likewise had mixed results: some studies report significantly decreased OS for TURBT (9 vs. 28 months [22], 14 vs. 39 months [23]) whereas others found no survival benefit of radical cystectomy over TURBT [24,25].…”

Section: Key Pointsmentioning

confidence: 99%

The role of surgery for loco-regional and advanced urological cancers

Chow

Tay

Yuen

et al. 2022

Current Opinion in Urology

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Purpose of reviewThere is a general misconception that surgery is the antithesis of palliation. However, symptom mitigation, the basic tenet of palliative interventions, can be achieved by invasive procedures. Surgical care, thus, plays an important role in palliative oncology, alongside radiation and systemic therapy. There is global movement to improve palliation in oncology, and thus it is timely to evaluate the role of surgical interventions can play in this setting. Recent findingsMany of the surgical interventions done with palliative intent were first established as curative options. Most studies looked at interventions for local control of primary tumour including extirpative surgeries, while some studies studied pain relief for bone metastases. Results show that patients have an acceptable survival outcome and complication rate comparable to those done in the curative setting. However, not all studies report functional outcomes and symptom-relief consistently, highlighting an unmet need. SummaryMore studies are needed to further define the role of surgery in palliative care. Randomized controlled trials studying surgical intervention in the palliative setting will be challenging because of lack of equipoise, inherent bias in patient and disease characteristics in those who undergo surgery. Nonetheless, studies should endeavour to study symptom-free survival and PROMs as meaningful endpoints of interventions performed in a palliative setting rather than solely focus on hard oncological endpoints of survival.

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“…The extension of the indications for radical cystectomy to elderly patients [20,21] and the progressive incorporation of neoadjuvant chemotherapy [13,14] into treatment protocols in Spain may have contributed to the decrease in mortality observed in the trend analysis, particularly in the group aged 75 and older. For this reason, it is important to continue implementing bladder-sparing treatments and systemic treatments and to perform cystectomies in fit patients regardless of their age [53].…”

Section: Health Services: Diagnosis and Treatmentmentioning

confidence: 99%

“…These data indicate that between 3.1 and 4.3% [15,16] of patients received NAC before 2010, with a percentage increase in its current use varying between 29.7% and 60.7% [16][17][18]. The indication for surgery in geriatric patients have been increasingly positive as surgical experience and life expectancy have improved [19], with cystectomy becoming established as a safe procedure in selected elderly patients [20,21].…”

Section: Introductionmentioning

confidence: 99%

Mortality Trends Related to Bladder Cancer in Spain, 1999–2018

Sanz

Martínez-Cayuelas

Gil-Guillén

et al. 2022

JCM

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Bladder cancer (BC) is an important cause of premature mortality (PM, <75 years). Spain has one of the highest BC mortality rates in Europe. The objective of this study was to analyse BC mortality trends between 1999 and 2018 in Spain. The study was based on data from the National Institute of Statistics (Instituto Nacional de Estadística—INE). Age-adjusted mortality rates (AAMRs) were calculated by sex and age group. A trend analysis was performed using Joinpoint regression models and years of potential life lost (YPLL). Mortality in men resulting from BC decreased in all age groups studied. This was not observed in women, for whom mortality only decreased in the ≥75 age group. Deaths due to BC occurred prematurely in 38.6% of men and in 23.8% of women, which indicated a greater impact on YPLL in men compared to women. Over the last 20 years, there has been a significant decrease in BC mortality rate, except in women under 75 years of age. Despite this temporal trend of decreasing mortality, BC continues to have a significant impact on YPLL, mainly in men. Given this context, it is important to direct more resources towards prevention and early diagnosis strategies to correct this situation.

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Comparative survival following different treatment modalities for stage T2 bladder cancer in octogenarians

Abstract: Compared to other treatment modalities, surgery, either radical cystectomy or partial cystectomy, offers the best OS and CSS for men aged 80 years or older with T2 bladder cancer.

Cited by 12 publications

References 16 publications

The prognostic role of preoperative serum albumin/globulin ratio in patients with bladder urothelial carcinoma undergoing radical cystectomy

The prognostic role of preoperative serum albumin/globulin ratio in patients with bladder urothelial carcinoma undergoing radical cystectomy

The role of surgery for loco-regional and advanced urological cancers

Mortality Trends Related to Bladder Cancer in Spain, 1999–2018

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