Comparative survival analysis of adjuvant therapy with iodine-131-labeled lipiodol to hepatic resection of primary hepatocellular carcinoma

Abstract

Postoperative adjuvant therapy with intra-arterial (131)I-lipiodol to hepatic resection of HCC significantly improves overall and disease-free survival rates and reduces recurrence rates. However, well-designed randomized trials are needed to arrive at conclusive evidence.

Management of hepatocellular carcinoma: an overview of major findings from meta-analyses

“…Two meta-analyses compared the outcomes of surgical resection in combination with I 131 lipiodol versus surgical resection alone [36, 40]. Both of them favored the combination therapy in terms of OS, DFS, and recurrence [36, 40].…”

On developing a pragmatic strategy for clinical trials: A case study of hepatocellular carcinoma

“…These comprise Items concerning clinical opinion (1), single arm (4), comparative (4) and RCTs (2), with 3 Elements providing updated information for their corresponding Items. Following publication of the two RCTs [3,7], two systematic overviews have been published [8,9]. These identified some Elements that had not been located earlier.…”

“…The first analysis was conducted on 14 November 2005 when the DMSB Table 1 Elements identified for the evaluation of the role of I131L in resectable hepatocellular carcinoma -more extensive summary details of some are provided by Gong et al (2014) (Table 2), the accumulated evidence from these, and from the earlier information, suggested a current smaller HR = 0.415 with a greater Prob (HR b 0.57) = 0.841 (Table 3). However, once combined with the interim data from the AHCC03 trial [H1], the HR = 0.53, and hence moved closer to the equivalence range, and with a correspondingly reduced Prob (HR b 0.57) = 0.624 (Table 3).…”

“…Our proposal is also a suggestion for additional stages to be added to systematic reviews and meta-analysis such as those of the four comparative studies and the two RCTs concerning the role of adjuvant I131L that have been published [8,9].…”

Effect of Nursing on Patients with Primary Liver Cancer before and after Transcatheter Arterial Embolization

“…Rehabilitation guidance was provided which included, postoperative rehabilitation phase in which metal nursing should be strengthened to increase patients' belief in rehabilitation to keep them in positive mood [9] . In addition, instructing patients to take appropriate exercise to improve immunity, and imparting patients with health knowledge and rehabilitation information to prevent postoperative complications.…”