Comparative study to evaluate the prevalence of deranged lipid profile and oral glucose tolerance test in polycystic ovarian syndrome patients with normal females: a prospective observational study

Abstract

Background: PCOS is a complex endocrine disorder characterized by menstrual dysfunction, anovulation, infertility and hyper androgenic symptoms with dyslipidaemia, cardiovascular diseases, and impaired glucose tolerance and type II diabetes mellitus. Multiple risk factors are involved in the pathogenesis of PCOS.Methods: A comparative evaluation of deranged lipid profile and OGTT in PCOS patients with normal females was done in patients with age group of 15 to 30 years. The Rotterdam criteria for PCOS was used for selection of the participants prospectively and a detailed history regarding period of amenorrhea, menstrual cycles, obstetric history, any past history of medical disorder were taken followed by general physical, systemic and obstetric examination. All the patients underwent Ultrasound examination, OGTT and lipid profile, prolactin, 17-OH progesterone and testosterone level.Results: A significant association of PCOS with deranged lipid profile and blood glucose tolerance and obesity was observed. Patients with PCOS had higher prevalence of oligomenorrhoea, infertility, hirsutism and acne. Furthermore, a statistically significant trend was seen where signs and symptoms like infertility, hirsutism and acne, deranged OGTT and dyslipidaemia were more frequently associated with increased BMI, sedentary life style intake of high calorie diets.Conclusions: An association between obesity, sedentary lifestyle, and dietary factors with PCOS was observed which can be modified to improve the health condition of the women with PCOS.