Comparative study to evaluate the anti-diabetic activity of commercially available extract of Tinospora cordifolia and Phyllanthus emblica in streptozocin induced diabetic rat

Pathak, Nishant; Bandyopadhyay, Arkapal; Kumar, Gyanendra; Chaurasia, Rajan; Varma, Kachnar

doi:10.18203/2319-2003.ijbcp20162486

Cited by 5 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The aqueous extracts of P. niruri were thoroughly studied for their physicochemical characteristics and organoleptic characters, and it was described that the displayed high antidiabetic activity is mainly due to the presence of phenolics in the extracts [ 74 ]. P. emblica showed a significant reduction of glucose levels in blood plasma within 30 days of administration to streptozocin fed diabetic rats [ 75 ]. The fruits, leaves and flowers of P. emblica are rich in ellagitannins have been stated useful to ameliorate diabetes when tested in streptozotocin fed rats.…”

Section: Biological Activitiesmentioning

confidence: 99%

Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature

Nisar

Ahmed

et al. 2018

Molecules

View full text Add to dashboard Cite

Medicinal plants have served humans since prehistoric times to treat various ailments. Both developed and underdeveloped countries rely on traditional systems of medication using natural sources from plants. Phyllanthus is one of the largest genus in the family Phyllanthaceae, comprising over 700 well known species cosmopolitan in distribution mainly in the tropics and subtropics. Phyllanthus species are being in constant used in traditional medications to cure an array of human diseases (constipation, inhalation related, arthritis, loss of appetite, injuries, conjunctivitis, diarrhoea, running nose, common cold, malaria, blennorrhagia, colic, diabetes mellitus, dysentery, indigestion, fever, gout, gonorrheal diseases of males and females, skin itching, jaundice, hepatic disorders, leucorrhea, vaginitis, menstrual irregularities, obesity, stomach pains, and tumors), confectionaries, food industry, and in some pesticides. Phyllanthus species are rich in diversity of phytochemicals e.g., tannins, terpenes, alkaloids, glycosidic compounds, saponins, and flavones etc. More in depth studies are a direly needed to identify more compounds with specific cellular functions to treat various ailments.

show abstract

Section: Biological Activitiesmentioning

confidence: 99%

Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature

Nisar

Ahmed

et al. 2018

Molecules

View full text Add to dashboard Cite

show abstract

“…Several studies validating the therapeutic potential of Tinospora cordifolia for treatment of endocrine and metabolic disorders have been documented (Chakraborty 2016;Dhama et al 2017). The whole plant extract of Tinospora cordifolia has shown significant anti-diabetic activity by reduction of plasma glucose levels in alloxaninduced diabetic rats (Kinkar and Patel 2015) and streptozocin-induced diabetic rats (Pathak et al 2016). A novel polysaccharide isolated from Tinospora cordifolia stem extract has been found to possess -cell regenerative potential and significantly decreased plasma glucose, HBA1c, triglycerides and total cholesterol (Rajalakshmi and Anita 2016).…”

Section: Antidiabetic Potential Of Medicinal Plantsmentioning

confidence: 99%

Relevance of Traditional Antidiabetic Plants in The Covid-19 Pandemic Era

2022

Medicinal Plants: Ethnomedicine, Pharmacognosy and Therapeutic Values

View full text Add to dashboard Cite

Diabetes mellitus is a major endocrine disorder characterized by chronic hyperglycaemia with associated severe complications like diabetic nephropathy, retinopathy, peripheral neuropathy, atherosclerosis and increased susceptibility to infections. Covid-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) has been particularly more severe to people with co-morbidities like diabetes, cardiovascular diseases and other metabolic disorders. Diabetes and obesity appear to be strong risk factors for mortality in Covid-19. The prevalence of uncontrolled blood sugar levels and immunosuppressive treatments like corticosteroids have resulted in a surge of secondary bacterial as well as fungal infections like Mucormycosis in Covid patients, particularly in India. There are increasing reports of new-onset diabetes after Covid-19 infection. Prevention of diabetes and management of blood sugar levels, therefore is extremely significant in the current scenario. Medication for diabetes includes insulin injections and oral drugs like metformin that may have adverse side-effects. Many medicinal plants and polyherbal formulations used in the Indian Traditional systems of medicine can provide prophylactic and curative treatment as natural and safer alternatives for control of diabetes and insulin resistance. The article is intended to give an update of plants like Berberis

show abstract

An overview of some Indian vegetables, fruits, and spices effective in diabetes and metabolic disorders: Current status and future scenarios

Pundarikakshudu,

Patel,

Shah

2024

Antidiabetic Medicinal Plants

View full text Add to dashboard Cite

Comparative study to evaluate the anti-diabetic activity of commercially available extract of Tinospora cordifolia and Phyllanthus emblica in streptozocin induced diabetic rat

Cited by 5 publications

References 10 publications

Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature

Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature

Relevance of Traditional Antidiabetic Plants in The Covid-19 Pandemic Era

An overview of some Indian vegetables, fruits, and spices effective in diabetes and metabolic disorders: Current status and future scenarios

Contact Info

Product

Resources

About