Comparative study on Toxoplasma infection between Malaysian and Myanmar pregnant women

Andiappan, Hemah; Nissapatorn, Veeranoot; Sawangjaroen, Nongyao; Nyunt, Myat Htut; Lau, Yee Ling; Khaing, Si Lay; Aye, Khin Myo; Mon, Nan Cho Nwe; Kumar, Thulasi; Onichandran, Subashini; Adenan, Noor bin Mat

doi:10.1186/preaccept-2076192715134533

Cited by 7 publications

(11 citation statements)

References 20 publications

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“…In another study in which a similar survey was administered, general knowledge of parasitosis was also low (less than 10%). 11 These findings indicate the importance of educating pregnant women and the community in general about preventive measures. 9,19,20 In a study of pregnant and postpartum women in three Asian countries, 19.4% of respondents correctly identified contact with cat feces as the main mode of transmission of toxoplasmosis.…”

Section: Discussionmentioning

confidence: 99%

“…24 Improving knowledge of preventive measures and appropriate behavioral changes can reduce infection rates. 11 Investigation of the prevalence of infectious diseases in different regions is essential to create health care policies and programs that can effectively improve care and public awareness to prevent or minimize the occurrence of new cases. 25 Only half (46/97) of the patients in our study had been serologically tested for toxoplasmosis.…”

Section: Discussionmentioning

confidence: 99%

“…9 Because the disease is usually asymptomatic, education of pregnant women for prevention is critical in order to reduce infection rates. 10,11 Accordingly, the present study aimed to assess the knowledge concerning toxoplasmosis and its potential health effects in a sample of pregnant and postpartum women managed at the University Hospital of the city of Rio Grande, Rio Grande do Sul state, Brazil.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Pregnant and Postpartum Women's Knowledge about Toxoplasmosis in Rio Grande – RS, Brazil

Lehmann

Santos

Scaini

2016

Rev Bras Ginecol Obstet

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Toxoplasmosis a parasitic zoonosis of global distribution, responsible for disorders during gestation can cause fetal death or congenital anomalies. To evaluate the knowledge of toxoplasmosis among pregnant and postpartum women treated at the University Hospital of the city of Rio Grande, Rio Grande do Sul, Brazil. This was a cross-sectional study of 100 pregnant and postpartum women at the University Hospital. Participants answered a self-administered questionnaire and gave consent for data relating to serological examinations to be abstracted from their medical records. The proportion of women who received information about toxoplasmosis was higher among those who received care in the private health care system (52.9%) than among those cared for in the public health care system (25.0%). Only 55.7% of women reported having some knowledge about toxoplasmosis. Of these, 53.7% received information during the prenatal period. However, most participants were unable to answer questions about preventive measures and modes of infection. Of the 100 patients in the study, only 46 underwent serologic testing for toxoplasmosis, 65.2% of whom tested negative (IgG). Findings from this study are relevant to the training of health professionals regarding toxoplasmosis education and prevention. Improved education for health care providers and patients can lead to earlier diagnoses and reductions in adverse outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Pregnant and Postpartum Women's Knowledge about Toxoplasmosis in Rio Grande – RS, Brazil

Lehmann

Santos

Scaini

2016

Rev Bras Ginecol Obstet

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“…In Myanmar, Toxoplasma seroprevalence in children was observed at 28.4 to 43.8%. 12,13,[16][17][18][19][20][21] Although studies were done in pregnant women, there was a dearth of intensive studies on children born from infected mothers.…”

Section: Introductionmentioning

confidence: 99%

Congenital Toxoplasmosis: The Unknown Disease Burden of Pregnant Women in Southeast Asia

Salibay

Torres

Salibay

et al. 2017

J Pediatr Infect Dis

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Congenital toxoplasmosis (CT) is caused by Toxoplasma gondii which is an Apicomplexa parasite that requires a cat for its sexual cycle and a wide array of warm-blooded animals, including man for its asexual cycle. CT develops due to vertical transmission of the parasite from an infected mother to the child. It is in this manner when the unborn child becomes susceptible to infection. The literature review revealed that 26.0% of infants born from T. gondii infected mother are subclinically infected at birth and 10.0% are either mildly or severely clinically affected, while 3.0% of neonates die. Predominant manifestation of CT is encephalomyelitis, initiated by formation of microglial nodules in the brain. However, the most remarkable classical triad signs of toxoplasmosis are hydrocephalus or microcephalus, intracranial calcification, and retinochoroiditis. Hence, this review focused on the risks of the child from developing CT, the role of the pregnant women on the transmission of the parasite, and the risks of acquiring the parasite by the expectant mothers from Southeast Asia vis-à-vis transmitting the same to the unborn child. Likewise, this review also included the methods used for the diagnosis of CT and its importance in early detection and management of the disease by assessing practical means of controlling the incidence and preventing further transmission of the parasite.

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“…5,6 A recent study reported a 42.3% T. gondii seroprevalence rate among a population of pregnant women. 7 Immunocompetent individuals with acute toxoplasmosis are commonly asymptomatic or show mild symptoms. However, pregnant women who acquire acute (primary) infection during pregnancy can develop congenital toxoplasmosis with fetal and neonatal complications including severe neurologic and ocular diseases that may last for life.…”

Section: Introductionmentioning

confidence: 99%

Identification, production and assessment of twoToxoplasma gondiirecombinant proteins for use in aToxoplasmaIgG avidity assay

Teh

Amerizadeh

Osman

et al. 2016

Pathogens and Global Health

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The IgG avidity assay is an important tool in the management of suspected toxoplasmosis in pregnant women. This study aimed to produce new Toxoplasma gondii recombinant proteins and to assess their usefulness in an IgG avidity assay. Toxoplasma positive and negative serum samples were used, the former were categorized into low (LGA) and high (HGA) IgG avidity samples. Immunoblots were performed on 30 T. gondii cDNA clones to determine the reactivity and IgG avidity to the expressed proteins. Two of the clones were found to have diagnostic potential and were analyzed further; AG12b encoded T. gondii apical complex lysine methyltransferase (AKMT) protein and AG18 encoded T. gondii forkhead-associated (FHA) domain-containing protein. The Histagged recombinant proteins, rAG12b and rAG18, were expressed and tested with LGA and HGA samples using an IgG avidity western blot and ELISA. With the IgG avidity western blot, rAG12b identified 86.4% of LGA and 90.9% of HGA samples, whereas rAG18 identified 81.8% of both LGA and HGA samples. With the IgG avidity ELISA, rAG12b identified 86.4% of both LGA and HGA samples, whereas rAG18 identified 77.3% of LGA and 86.4% of HGA serum samples. This study showed that the recombinant antigens were able to differentiate low avidity and high avidity serum samples, suggesting that they are potential candidates for use in the Toxoplasma IgG avidity assay.

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Comparative study on Toxoplasma infection between Malaysian and Myanmar pregnant women

Cited by 7 publications

References 20 publications

Evaluation of Pregnant and Postpartum Women's Knowledge about Toxoplasmosis in Rio Grande – RS, Brazil

Evaluation of Pregnant and Postpartum Women's Knowledge about Toxoplasmosis in Rio Grande – RS, Brazil

Congenital Toxoplasmosis: The Unknown Disease Burden of Pregnant Women in Southeast Asia

Identification, production and assessment of twoToxoplasma gondiirecombinant proteins for use in aToxoplasmaIgG avidity assay

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