Convective heat transfer enhancement in a round tube mounted with a centrally perforated twisted tape (CP-TT) was numerically investigated. Influences of space of cut ratio (s/w = 0.5, 0.7 and 0.9) and twist ratio (y/w = 2.0, 3.0 and 4.0) under laminar and turbulent flow regimes on heat transfer characteristics were determined. Numerical encompassed Reynolds numbers (Re) from 400 to 2000 for laminar flow and 5000 to 15,000 for turbulent flow. At a given Reynolds number, the tubes with centrally perforated twisted tape (CP-TT) inserts offer higher heat transfer rate than those the plain tube alone. Heat transfer enhancement in a round tube equipped with centrally perforated twisted tape (CP-TT) is strongly dependent on twist ratio (y/w) and space of cut ratio (s/w). The results also found that the heat transfer rate (Nu) and friction factor (f) increase as twist ratio (y/w) and space of cut ratio (s/w) decreases. The thermal enhancement factor () increases as space of cut ratio (s/w) and twist ratio (y/w) decreases in laminar flow regime while the opposite trend is observed in the turbulent flow regime. Over the studied range, the tube equipped with centrally perforated twisted tape (CP-TT) with s/w = 0.5 and y/w = 2.0 gives the maximum thermal enhancement factor () of 8.92 for laminar flow at Re = 2000. In turbulent flow at Re = 5000, the centrally perforated twisted tape (CP-TT) with s/w = 0.9 and y/w = 3.0 yields the maximum thermal enhancement factor () of 1.33. In addition, the flow structure, temperature field and local Nusselt number of heat exchanger tubes equipped with centrally perforated twisted tape (CP-TT) are also reported for the clarification of heat transfer and flow topology mechanisms.