Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats

Süleyman, Halis; Çadırcı, Elif; Albayrak, Abdulmecit; Polat, Beyzagül; Halıcı, Zekai; Koç, Feride; Hacımüftüoğlu, Ahmet; Bayır, Yasin

doi:10.1016/j.cbi.2009.03.002

Cited by 63 publications

(51 citation statements)

References 44 publications

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“…The decrease or inhibition of gross hemorrhagic lesion areas is regarded as a valuable indication that test substances have favorable gastric mucosa protective effects based on previous efficacy studies conducted by other researchers (Mori, Hayashi, Iwashima, Matsunaga, & Saito, 2006; Süleyman et al., 2009). Reduced gross lesions indicate more favorable protective effects (Oyagi et al., 2010).…”

Section: Discussionmentioning

confidence: 99%

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Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Lim¹,

Song

Park

et al. 2018

Food Science & Nutrition

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This study was designed to observe the possible protective effects of a triple‐fermented barley (Hordeum vulgare L.) extract (FBe) obtained by saccharification and using Saccharomyces cerevisiae and Weissella cibaria in alleviating gastric damage induced by a hydrochloric acid (HCl) and ethanol (EtOH) mixture in mice. After oral administration of FBe (300, 200, and 100 mg/kg) followed by 1 hr before and after the single treatment of HCl/EtOH (H/E) mixture, the hemorrhagic lesion scores, histopathology of the stomach, gastric nitrate/nitrite content, lipid peroxidation, and antioxidant defense systems including catalase and superoxide dismutase activities were observed. Following a single oral treatment of H/E‐induced gastric damages as measured by hemorrhagic gross lesions and histopathological gastric, ulcerative lesions were significantly and dose‐dependently (p < 0.01 or p < 0.05) inhibited in mice, when all three different doses of FBe were administered as compared to those in H/E control mice. In particular, FBe also increased gastric nitrate/nitrite content and strengthened the antioxidant defense, with a decrease in the level of gastric lipid peroxidation, but increased the activities of CAT and SOD. Moreover, the effects of FBe are comparable to that of ranitidine, a reference drug. The obtained results suggest that this fermented barley extract prevented mice from H/E‐induced gastric mucosal damages through the suppression of inflammatory responses and oxidative stress‐responsive free radicals. Thus, FBe can be useful to treat patients suffering from gastric mucosal disorders as a potent food supplement, and thereby, it would increase the necessity of application in the food industry.

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Section: Discussionmentioning

confidence: 99%

“…Ulcer areas on the stomach surface were examined microscopically and measured by an automated computer‐based image analyzer (iSolution FL ver 9.1, IMT i‐solution Inc., Quebec, Canada) according to the methods of Süleyman et al. (2009), Morais et al. (2010) and Oyagi Oyagi et al.…”

Section: Methodsmentioning

confidence: 99%

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Lim¹,

Song

Park

et al. 2018

Food Science & Nutrition

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show abstract

“…Gastric injury was determined by calculating ulcer score according to the method of Suleyman et al (2009a). Stomachs were tacked to a planer surface with small pins and then the total area of stomach and ulcerous areas were each traced using a cellophane sheet for analysis.…”

Section: Determination Of Gastric Mucosal Injurymentioning

confidence: 99%

Serotonin and histamine mediate gastroprotective effect of fluoxetine against experimentally-induced ulcers in rats

Sokar

Elsayad

Ali

2016

Journal of Immunotoxicology

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Research in the treatment of gastric ulcer has involved the investigation of new alternatives, such as anti-depressant drugs. The present study was designed to investigate the gastroprotective effects of fluoxetine against indomethacin and alcohol induced gastric ulcers in rats and the potential mechanisms of that effect. Fluoxetine (20 mg/kg) was administered IP for 14 days. For comparative purposes, other rats were treated with ranitidine (30 mg/kg). Thereafter, after 24 h of fasting, INDO (100 mg/kg) or absolute alcohol (5 ml/kg) was administered to all rats (saline was administered to naïve controls) and rats in each group were sacrificed 5 h (for INDO rats) or 1 h (for alcohol rats) later. Macroscopic examination revealed that both fluoxetine and ranitidine decreased ulcer scores in variable ratios, which was supported by microscopic histopathological examination. Biochemical analysis of fluoxetine-or ranitidine-pre-treated host tissues demonstrated reductions in tumor necrosis factor (TNF)-and myeloperoxidase (MPO) levels and concomitant increases in gastric pH, nitric oxide (NO) and reduced glutathione (GSH) contents. Fluoxetine, more than ranitidine, also resulted in serotonin and histamine levels nearest to control values. Moreover, immuno-histochemical analysis showed that fluoxetine markedly enhanced expression of cyclooxygenases COX-1 and COX-2 in both models; in comparison, ranitidine did not affect COX-1 expression in either ulcer model but caused moderate increases in COX-2 expression in INDOinduced hosts and high expression in alcohol-induced hosts. The results here indicated fluoxetine exhibited better gastroprotective effects than ranitidine and this could be due to anti-secretory, anti-oxidant, anti-inflammatory and anti-histaminic effects of the drug, as well as a stabilization of gastric serotonin levels. ARTICLE HISTORY

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“…These 48 rats were separated into 8 groups, each consisting of 6 rats. All fasted for 24 hours, and then doses of 10, 20, 40, 80, 150 mg/kg moclobemide and 20 mg/kg famotidine [16,18] were administered by oral gavage to six of the groups. The other two groups, indomethacin control and healthy intact, were administered an equal volume of water.…”

Section: Moclobemide Effects On Indomethacin-induced Ulcers In Ratsmentioning

confidence: 99%

Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

Albayrak¹,

Hakan²,

Süleyman³

2015

EAJM

Self Cite

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Objective: Even though there are many drugs for the treatment of gastric ulcers, these drugs sometimes cannot succeed. Since the 1950s, antidepressant drugs have been used for several non-psychiatric indications. Many antidepressant drugs have been shown experimentally to produce antiulcer activity in various ulcer models. Moclobemide is an antidepressant drug which inhibits monoamine oxidase-A (MAO) enzyme selectively. When it is compared to the classic antidepressants drugs, moclobemide is the first choice in depression treatment because of its effectiveness and less side effects. This study aimed to investigate the antiulcer effects of moclobemide and to determine its relationship with antioxidant mechanisms in rat gastric tissue. Materials and Methods:The antiulcer activities of 10, 20, 40, 80, 150 mg/kg moclobemide and 20 mg/kg famotidine have been investigated on indomethacin-induced ulcers in rats, and the results have been compared with that of the control group. Results:Moclobemide decreased the indomethacin-induced ulcers significantly at all doses used. While used doses of moclobemide increased the glutathione (GSH), nitric oxide (NO) level and superoxide dismutase (SOD) activity, it decreased the malondialdehyde (MDA) level and myeloperoxidase (MPO) activity in stomach tissue when compared to the control group. Conclusion:It is determined that an antidepressant drug, moclobemide is a potent anti-ulcer agent. Inhibition of toxic oxidant radicals and activation of antioxidant mechanisms play a role in its antiulcer effect mechanisms.

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Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats

Cited by 63 publications

References 44 publications

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Serotonin and histamine mediate gastroprotective effect of fluoxetine against experimentally-induced ulcers in rats

Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

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