Comparative study on the efficacy of Garcinia kola in reducing some heavy metal accumulation in liver of Wistar rats

Possible mechanisms of action of the hypotensive effect ofAnnona muricata(soursop) in normotensive Sprague–Dawley rats

“…However, many of these medications produce undesirable side effects. As a result, there is much interest in the use of alternative medicine in the treatment of hypertension and in the search for plants with hypotensive activity and less adverse side effects (Nwokocha et al, 2011c. Brussel (2004) reported that a decoction made from the fruits, leaves, and twigs of Annona muricata Linn (Annonaceae) is drunk to treat high blood pressure, and there have been reports that the plant extract has antihypertensive properties (Carbajal et al, 1991;Adeyemi et al, 2008).…”

Possible mechanisms of action of the aqueous extract ofArtocarpus altilis(breadfruit) leaves in producing hypotension in normotensive Sprague–Dawley rats

“…Herbal remedies are known to affect the dynamics of drug and chemical interactions (Nwokocha et al, 2011(Nwokocha et al, , 2012 and these enzymes are of significant concern to drug-drug interactions.…”

In Vivo Carbon Tetrachloride-Induced Hepatoprotective and in Vitro Cytotoxic Activities of Garcinia Hombroniana (Seashore Mangosteen)

“…Previously, several investigations carried out on the pharmacological effects of chemical constituents isolated from Garcinia species, have reported their anti-hepatotoxic and cytotoxic activities. For example, kolaviron (a mixture of GB1, GB2 and kolaflavonone) isolated from G. kola seeds (Kapadia et al, 1994) is reported to have hepatoprotective properties (Nwokocha et al, 2011). Similaly, Panda et al (2013), and Mahendran and Devi (2001) in their invsitgation on G. indica and G. cambogia, reported their antihepatotoxic activities against D-galactosamine-, antitubercular drug-, and ethanol-induced toxicities.…”