Comparative study on the efficacy of and the tolerance to the triazolodiazepines, triazolam and brotizolam.

Goetzke, Edda; Findeisen, Peter; Welbers, Inés B.

doi:10.1111/j.1365-2125.1983.tb02318.x

Cited by 10 publications

(4 citation statements)

References 11 publications

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“…In both cases, drug therapy (any) appeared to be superior to placebo with respect to sleep latency; however, no statistical analysis was provided by Goetzke et al . 38 No statistically significant differences were identified between the active arms of either study ( table 3 ).…”

Section: Resultsmentioning

confidence: 89%

“…Two randomised control trials evaluated sleep latency with triazolam. 37 38 Morgan et al (n=357) compared triazolam to zolpidem and placebo, while Goetzke et al (n=79) compared it to brotizolam and placebo. In both cases, drug therapy (any) appeared to be superior to placebo with respect to sleep latency; however, no statistical analysis was provided by Goetzke et al .…”

Section: Resultsmentioning

confidence: 99%

“…Four reported no differences between drugs and/or placebo. 34 37 38 41 The study by Lupolover et al 36 described an improved state on awakening by patient self-report in those taking midazolam compared to oxazepam.…”

Section: Resultsmentioning

confidence: 99%

“… 37 Allergic type skin reactions were reported in two patients—one was associated with triazolam; the other, described as pruritus, occurred in a patient with pancreatitis and whether the reaction was attributed to benzodiazepines or placebo was not specified in the study. 36 38 …”

Section: Resultsmentioning

confidence: 99%

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Pharmacological interventions to improve sleep in hospitalised adults: a systematic review

et al. 2016

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ObjectivesPatients often suffer from disturbed sleep in hospital. Poor-quality sleep in hospitalised patients has been associated with significant morbidity and pharmacological sleep aids are often prescribed. The objective of this systematic review is to evaluate the comparative efficacy and safety of pharmacological interventions used for sleep in hospitalised patients.Setting/participantsWe searched MEDLINE, Embase, the Cochrane database and grey literature for prospective studies that evaluated sleep in hospitalised adults after a pharmacological intervention.Primary and secondary outcome measuresTwo reviewers assessed studies for inclusion and extracted data for efficacy outcomes, including sleep efficiency, sleep latency, sleep fragmentation and objectively measured sleep stage distribution. Risk of bias was assessed and meta-analyses were planned contingent upon homogeneity of the included studies.ResultsAfter screening 1920 citations, 15 studies involving 861 patients were included. Medications studied included benzodiazepines, nonbenzodiazepine sedatives, melatonin, propofol and dexmedetomidine. Five studies were deemed to be of high quality. Heterogeneity and variable outcome reporting precluded meta-analysis in most cases. No consistent trends with respect to sleep efficiency, quality or interruptions were observed identifying a drug or drug class as superior to another or no treatment. Benzodiazepines appeared to be better than no treatment with respect to sleep latency, but this was not consistently demonstrated across all studies. Sleep stage distribution shows that sleep in hospital is dominated by stages N1 and N2.ConclusionsThere is insufficient evidence to suggest that pharmacotherapy improves the quality or quantity of sleep in hospitalised patients suffering from poor sleep. No drug class or specific drug was identified as superior even when compared to placebo or no treatment. Although 15 studies were included, the quality of evidence was limited by their quality and size. Larger, better-designed trials in hospitalised adults are needed.

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Section: Resultsmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Pharmacological interventions to improve sleep in hospitalised adults: a systematic review

et al. 2016

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Sedative‐Hypnotics

Vida¹,

Yevich

2003

Burger's Medicinal Chemistry and Drug Discovery

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This chapter focuses on sedative‐hypnotic drugs that are sued to alleviate the condition of sleep disturbances. One‐third of our life is spent in sleep; the lack, of which, can cause serious physical, social, and psychological problems. This chapter describes the features of an ideal hypnotic drug and provides a classification of sedative‐hypnotic drugs currently in use. These include the barbiturates, benzodiazepines, halogenated sedative‐hypnotics, heterocyclic sedative‐hypnotics, antihistamines, and other sedative‐hypnotics. Individual members of all of these classes of drugs are discussed in detail. The chapter also describes the physiology of sleep and the sleep cycle, including the nonrapid eye movement and rapid eye movement sleep. A list of neurotransmitters and nonhypnotic drugs that have a direct and indirect action on the sleep cycle are provided. The pharmacology including the evaluation of sedative‐hypnotics are also given. The chapter refers to the discovery of one of the most frequently prescribed hypnotic drugs, Zolpidem. The chapter also examines structure‐activity relationships, recent developments, things to come, and available websites.

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Benzodiazepines and related drugs for insomnia in palliative care

Hirst¹,

Sloan

2001

Cochrane Database of Systematic Reviews

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Comparative study on the efficacy of and the tolerance to the triazolodiazepines, triazolam and brotizolam.

Cited by 10 publications

References 11 publications

Pharmacological interventions to improve sleep in hospitalised adults: a systematic review

Pharmacological interventions to improve sleep in hospitalised adults: a systematic review

Sedative‐Hypnotics

Benzodiazepines and related drugs for insomnia in palliative care

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