Comparative study on the antioxidant capacities of synthetic influenza inhibitors and ellagic acid in model systems

Pavlova, Elitsa L.; Zografov, Nikolay; Simeonova, Lora

doi:10.1016/j.biopha.2016.07.046

Cited by 17 publications

(8 citation statements)

References 42 publications

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“…In recent decades, EA is attracting great attention due to its pronounced antioxidant [15][16][17][18][19][20][21][22][23], anti-inflammatory [24][25][26][27][28][29], antimutagenic [30][31][32][33], and antiproliferative properties [34][35][36][37][38][39] and its therapeutic potential in the treatment of several human diseases. Numerous studies have shown that EA may be involved in regulating a spectrum of cellular signaling pathways to prevent, mitigate, or slow down the progression of chronic disorders, including cardiovascular [40][41][42][43] and neurodegenerative diseases [44][45][46][47], diabetes [48][49][50][51], and cancer [38,[52][53][54].…”

Section: Introductionmentioning

confidence: 99%

Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential

Sharifi‐Rad

Quispe

Castillo

et al. 2022

Oxidative Medicine and Cellular Longevity

160

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Ellagic acid (EA) is a bioactive polyphenolic compound naturally occurring as secondary metabolite in many plant taxa. EA content is considerable in pomegranate (Punica granatum L.) and in wood and bark of some tree species. Structurally, EA is a dilactone of hexahydroxydiphenic acid (HHDP), a dimeric gallic acid derivative, produced mainly by hydrolysis of ellagitannins, a widely distributed group of secondary metabolites. EA is attracting attention due to its antioxidant, anti-inflammatory, antimutagenic, and antiproliferative properties. EA displayed pharmacological effects in various in vitro and in vivo model systems. Furthermore, EA has also been well documented for its antiallergic, antiatherosclerotic, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties. This review reports on the health-promoting effects of EA, along with possible mechanisms of its action in maintaining the health status, by summarizing the literature related to the therapeutic potential of this polyphenolic in the treatment of several human diseases.

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Section: Introductionmentioning

confidence: 99%

Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential

Sharifi‐Rad

Quispe

Castillo

et al. 2022

Oxidative Medicine and Cellular Longevity

160

View full text Add to dashboard Cite

show abstract

“…It was also found that the antioxidant activity of the phenolic compounds may be related to the chelation of metal ions. In addition, EA (10 −4 and 1.75.10 −5 M) has antioxidant activity against hydroxyl radical, superoxide radical, and H 2 O 2 oxidation, especially for superoxide radical (Pavlova et al, 2016), which may be related to chelation and phenol activity, showing that EA has a strong antioxidant effect.…”

Section: Bioactivity Of Ellagic Acidmentioning

confidence: 99%

The bioactivity and applications of pomegranate peel extract: A review

Xiang

Wen

et al. 2022

Journal of Food Biochemistry

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Pomegranate peel (PP) is a by-product in the processing of pomegranate products, which is usually discarded as a waste. However, a large number of researches have shown that pomegranate peel extract (PPE) is rich in a variety of phenolic substances, among which ellagic acid (EA), as one of the main active components, has significant biological activities, such as anti-oxidation, anti-tumor, anti-inflammatory, neuroprotection, anti-viral, and anti-bacterial. We analyzed the mechanism of EA's biological activity, and discussed its application in the food industry, for instance, food preservation, food additives, and functional foods. Combined with the research status of PPE, we discussed the limitations and development potential of PPE, in order to provide theoretical reference and scientific basis for the development and utilization of pomegranate by-products. Practical applicationsPomegranate peel (PP), the inedible part of the fruit, is usually treated as waste. In recent years, researchers have been committed to exploring various bioactive ingredients in PP and exploring its potential benefits to human health, which has far-reaching significance. In this paper, the chemical constituents of polyphenols in PP were reviewed, mainly focusing on the biological activity and mechanism of ellagic acid (EA).We reviewed the applications and invention patents of pomegranate peel extract (PPE) in food field, including food preservation, food additive, and functional foods, providing reference for the recycling and reuse of PP.

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“…For this reason, its pharmacokinetic properties should be enhanced [222]. Other studies have described the synergy between ellagic acid and several antimalarial drugs, which could allow for dose reduction in the treatment of malaria, with the concomitant reduction in potential side effects [230].…”

Section: Other Properties Of Interest Of Ellagic Acidmentioning

confidence: 99%

A Pharmacological Update of Ellagic Acid

et al. 2018

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Ellagic acid is a common metabolite present in many medicinal plants and vegetables. It is present either in free form or as part of more complex molecules (ellagitannins), which can be metabolized to liberate ellagic acid and several of its metabolites, including urolithins. While ellagic acidʼs antioxidant properties are doubtless responsible for many of its pharmacological activities, other mechanisms have also been implicated in its various effects, including its ability to reduce the lipidemic profile and lipid metabolism, alter pro-inflammatory mediators (tumor necrosis factor-α, interleukin-1β, interleukin-6), and decrease the activity of nuclear factor-κB while increasing nuclear factor erythroid 2-related factor 2 expression. These events play an important role in ellagic acidʼs anti-atherogenic, anti-inflammatory, and neuroprotective effects. Several of these activities, together with the effect of ellagic acid on insulin, glycogen, phosphatases, aldose reductase, sorbitol accumulation, advanced glycation end-product formation, and resistin secretion, may explain its effects on metabolic syndrome and diabetes. In addition, results from recent research have increased the interest in ellagic acid, both as a potential protective agent of the liver and skin and as a potential anticancer agent, due to the specific mechanisms affecting cell proliferation, apoptosis, DNA damage, and angiogenesis and its aforementioned anti-inflammatory properties. Taken together, these effects make ellagic acid a highly interesting compound that may contribute to different aspects of health; however, more studies are needed, especially on the compoundʼs pharmacokinetic profile. In this review, we selected papers published from 2005 to the present.

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Comparative study on the antioxidant capacities of synthetic influenza inhibitors and ellagic acid in model systems

Cited by 17 publications

References 42 publications

Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential

Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential

The bioactivity and applications of pomegranate peel extract: A review

A Pharmacological Update of Ellagic Acid

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