Comparative Study on Hypnotics of Barbituric Acid Series

Pyrazolylmethylenepyrimidinetrione: Synthesis, Characterization and DFT Analysis

“…In addition to bioactivity, pyrazoles have potential for other applications such as optical materials, dyes, catalysts, solar cells, polymers, ammunition and corrosion inhibitors [13]. Similarly, barbituric acid derivatives attained the interest of synthetic chemist due to its spectrum of bioactivity such as hypnotic [14], [15] sedative [16], anticonvulsant [17], [18], antimicrobial [19] anaesthetic [20], anticancer and antitumor properties [21], [22]. Also, it plays vital role in dye sensitized solar cells as anchoring unit [23].…”

XXXV. Value of Barbital before Local Anesthesia

“…The salts of barbituric acid have been found clinically to abolish the unpleasant symptoms of cocain and novo cain poisoning in local anesthesia, eliminating such symptoms as collapse and pallor. 4. It has been found satisfactory to give 5 or 10 grains of sodium barbital or one and one-half grains of neonal by mouth one hour before operation.…”