Comparative Study on Gastric Secretory Function between Benign Gastric Polyp and Elevated Type of Early Stomach Cancer with Special Reference to Histological Findings of Gastric Mucosa

Abstract

In cases of elevated type of early cancer and benign polyp of the stomach, gastric analysis was performed and the results were compared with histological findings of gastric mucosa. Both clinical entities were found to show lowered acid and pepsin secretory functions reflecting severe and extensive atrophic changes of gastric mucosa. Dissociation in secre tory disturbance between acid and pepsin was also noticed. gastric polyp; early stomach cancer; mucosal atrophic change; pepsin Both benign polyp and elevated type of early cancer of the stomach are known to be accompanied by mucosal atrophic changes of various degrees around the lesion (Cornet et al. 1971). However, the clinical course and prognosis of these elevated lesions are entirely different in these two pathological entities.Owing to difficulties in detecting gastric cancer of an early stage, pathophysio -logical differences between benign polyp and elevated type of early cancer of the stomach remain still obscure.The purpose of the present investigation is to compare gastric secretory functions in these two pathological entities and to relate the results to histological findings of gastric mucosa. MATERIALS AND METHODSSubjects. 28 cases of benign gastric polyp and 21 cases of early stomach cancer located near the angular incisure were chosen. The cases of elevated type of early cancer of the stomach consisted of 7 cases of type I and 14 cases of type IIa according to the classification of Japanese Endoscopic Society. Multiple specimens were obtained from the mucosa of the anterior and the posterior wall according to the rule of Ishimori et al. (1974)