Comparative study on electrocrystallization of calcium phosphate ceramics on commercially pure titanium and selective laser melting titanium

Sun, Xuetong; Lin, Huaishu; Chen, Xianshuai; Zhang, Peng

doi:10.1016/j.matlet.2016.12.051

Cited by 11 publications

(3 citation statements)

References 15 publications

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“…Recent advancements in three-dimensional printing (3D printing) technology have opened new horizons for fabrication of various implants using different materials such as polymers and metals. − Accordingly, the application of 3D printing to fabricate implants will result in revolutionary improvements, among which is the flexibility in implant design to obtain different shapes of implants with tuned dimensions such as flat substrates, screws, wires, or even a complete joint. , More importantly, 3D printing will allow “on demand” implants which are designed especially for each patient that can be fabricated very quickly in a clinical environment. At the same time, implant manufacturing companies using this technology will be able to deliver implants on request instead of massive production and storage of implants.…”

Section: Introductionmentioning

confidence: 99%

Engineering of Micro- to Nanostructured 3D-Printed Drug-Releasing Titanium Implants for Enhanced Osseointegration and Localized Delivery of Anticancer Drugs

Maher

Kaur²,

Lima-Marques³

et al. 2017

ACS Appl. Mater. Interfaces

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Primary and secondary bone cancers are major causes of pathological bone fractures which are usually treated through implant fixation and chemotherapy. However, both approaches face many limitations. On one hand, implants may suffer from poor osseointegration, and their rejection results in repeated surgery, patient's suffering, and extensive expenses. On the other hand, there are severe systemic adverse effects of toxic chemotherapeutics which are administrated systemically. In this paper, in order to address these two problems, we present a new type of localized drug-releasing titanium implants with enhanced implants' biointegration and drug release capabilities that could provide a high concentration of anticancer drugs locally to treat bone cancers. The implants are fabricated by 3D printing of Ti alloy followed by an anodization process featuring unique micro- (particles) and nanosurface (tubular arrays) topography. We successfully demonstrate their enhanced bone osseointegration and drug loading capabilities using two types of anticancer drugs, doxorubicin (DOX) and apoptosis-inducing ligand (Apo2L/TRAIL). In vitro study showed strong anticancer efficacy against cancer cells (MDA-MB-231-TXSA), confirming that these drug-releasing implants can be used for localized chemotherapy for treatment of primary and secondary bone cancers together with fracture support.

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Section: Introductionmentioning

confidence: 99%

Engineering of Micro- to Nanostructured 3D-Printed Drug-Releasing Titanium Implants for Enhanced Osseointegration and Localized Delivery of Anticancer Drugs

Maher

Kaur²,

Lima-Marques³

et al. 2017

ACS Appl. Mater. Interfaces

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“…Therefore, in accordance with previous studies [20,36] the formation of acicular α′-martensite through α-to-β phase transformation followed by rapid cooling of the β-phase is unlikely in the 100-8 FSSed sample as was confirmed by the SZ microstructure of the 100-8 FSSed sample in Figure 3(b,c). It is worth noting that the crystal structures of α-Ti and α′-martensite are identical and their lattice parameters are nearly the same [37]. Thus, the XRD analysis, although revealing the phases present in the microstructure of un-processed and FSSed processed CP-Ti samples, was unable to verify whether or not the α′-martensite has formed (Figure 6).…”

Section: Resultsmentioning

confidence: 99%

Enhancing the tribological properties of pure Ti by pinless friction surface stirring

Ashoori,

Jafarzadegan,

Taghiabadi

et al. 2023

Materials Science and Technology

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Friction surface stirring (FSS) was employed to enhance the tribological properties of commercially pure Ti (CP-Ti). Applying FSS under the optimised process parameters (i.e. rotation and traverse speeds of 100 rpm and 8 mm/min, respectively) was found to increase the surface hardness of as-received CP-Ti from about 200–630 HV. The sliding wear resistance was therefore increased by 76, 76, and 85% under applied loads of 5, 10, and 20 N, respectively. The average friction coefficient (AFC) of CP-Ti also reduced considerably by the FSS. For instance, the AFC was reduced from 0.67 ± 0.07 and 1.04 ± 0.14 to about 0.33 ± 0.03 and 0.45 ± 0.04 at the applied loads of 5 and 20 N, respectively. The wear and friction mechanisms were also discussed.

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“…The raw material of the SLM-Ti scaffolds was commercially spherical pure Ti powder (>99.5% purity) with particle size less than 30 μm. The SLM processes were performed as described in our previous study [19]. The samples obtained with the above process were sandblasted using Lepco peenmatic 620 s rig to eliminate the effect of surface roughness on the electrodeposition process.…”

Section: Methodsmentioning

confidence: 99%

Electrochemical Studies on CaP Electrodeposition on Three Dimensional Surfaces of Selective Laser Melted Titanium Scaffold

Sun

Lin²,

Zhang³

et al. 2019

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In this work, calcium phosphate (CaP) coating was electrodeposited on the three dimensional surface of SLM-Ti scaffolds. The in situ measurement showed that the potential variation within 5 mm thickness porous selective laser melting (SLM)-Ti samples was about 80 mV as a result of the low conductivity of CaP coatings. SEM observation results revealed that the coating morphology depended on the distance between the surface position of porous SLM-Ti electrode and the auxiliary electrode. Based on the compared electrochemical experiments, it was found that the top and the bottom surfaces of SLM-Ti scaffolds exhibited continuous nucleation and instantaneous nucleation behavior respectively. The Electrochemical impedance spectroscopy (EIS) results also revealed that the electrodeposition processes at different depth of SLM-Ti scaffolds were not synchronized. These differences were ultimately caused by the non-uniform distribution of the potential and the current inside porous SLM-Ti electrodes. The present work provides a basic research method for studying the mechanism of the electrochemical process on three dimensional surfaces of SLM-Ti scaffolds.

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Comparative study on electrocrystallization of calcium phosphate ceramics on commercially pure titanium and selective laser melting titanium

Cited by 11 publications

References 15 publications

Engineering of Micro- to Nanostructured 3D-Printed Drug-Releasing Titanium Implants for Enhanced Osseointegration and Localized Delivery of Anticancer Drugs

Engineering of Micro- to Nanostructured 3D-Printed Drug-Releasing Titanium Implants for Enhanced Osseointegration and Localized Delivery of Anticancer Drugs

Enhancing the tribological properties of pure Ti by pinless friction surface stirring

Electrochemical Studies on CaP Electrodeposition on Three Dimensional Surfaces of Selective Laser Melted Titanium Scaffold

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