Comparative study on costs incurred for treatment of patients with bacterial and fungal keratitis - A retrospective analysis

Radhakrishnan, Nita; Neha, Pathak; Subramanian, Krishnan Raja; Das, Daisy Rani; Ningombam, Reagan; Khaitan, Isha; Gandhi, Neha; Rahul, Ramesh; Prajna, N Venkatesh

doi:10.4103/ijo.ijo_2176_21

Cited by 11 publications

(10 citation statements)

References 14 publications

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“…When compared to patients with bacterial keratitis, patients with fungal keratitis incur significantly more costs on medications, irrespective of whether they heal with successful medical treatment or require surgery. The prolonged duration of treatment and the high costs of antifungal medications account for the significant economic burden of fungal keratitis [ 22 ].…”

Section: Epidemiology and Association With Povertymentioning

confidence: 99%

The Case for Fungal Keratitis to Be Accepted as a Neglected Tropical Disease

Brown

Kamwiziku

Oladele

et al. 2022

JoF

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Amongst the treatable cause of blindness among young people, fungal keratitis ranks high. There are an estimated 1,051,787 to 1,480,916 eyes affected annually, with 8–11% of patients having to have the eye removed. Diagnosis requires a corneal scraping, direct microscopy and fungal culture with a large number of airborne fungi implicated. Treatment involves the intensive application of antifungal eye drops, preferably natamycin, often combined with surgery. In low-resource settings, inappropriate corticosteroid eye drops, ineffective antibacterial therapy, diagnostic delay or no diagnosis all contribute to poor ocular outcomes with blindness (unilateral or bilateral) common. Modern detailed guidelines on fungal keratitis diagnosis and management are lacking. Here, we argue that fungal keratitis should be included as a neglected tropical disease, which would facilitate greater awareness of the condition, improved diagnostic capability, and access to affordable antifungal eye medicine.

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Section: Epidemiology and Association With Povertymentioning

confidence: 99%

The Case for Fungal Keratitis to Be Accepted as a Neglected Tropical Disease

Brown

Kamwiziku

Oladele

et al. 2022

JoF

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“…A significant proportion of these patients are admitted to hospital to assist in adherence to intensive topical antimicrobial therapy and enable closer monitoring. Cost evaluation of MK in the international literature is lacking with limited studies from the UK, USA, Taiwan and India [ 13 , 14 , 15 , 16 , 17 ]. The mean cost of procedural treatment from 2013–2018 for a patient with MK in the USA was estimated to be USD 1788.7 and in the UK as GBP 2855 (USD 3252) [ 14 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and Economic Cost Analysis of Microbial Keratitis from a Tertiary Referral Hospital in Australia

et al. 2023

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Microbial keratitis is the most common cause of infective vision loss. The causative organism varies by region, and most cases require intensive antimicrobial therapy. The purpose of this study was to analyse the causative organisms of microbial keratitis, its presentation and economic burden from a tertiary referral hospital in Australia. A retrospective review of 160 cases of microbial keratitis was performed, over a 5-year period from 2015–2020. A wide variety of costs were considered to determine the economic burden, using standardized data from the Independent Hospital Pricing Authority and the cost of personal income loss. Our study showed the most commonly occurring pathogens were Herpes Simplex (16%), Staphylococcus aureus (15.1%) and Pseudomonas aeruginosa (14.3%). A total of 59.3% of patients were admitted, with a median length of admission of 7 days. Median cost for all presentations of microbial keratitis was AUD 8013 (USD 5447), with costs significantly increasing with admission. The total annual cost of microbial keratitis within Australia is estimated to be AUD 13.58 million (USD 9.23 million). Our findings demonstrate that microbial keratitis represents a significant economic burden for eye-related diseases and the key driving factor for the cost is the length of admission. Minimizing the duration of admission, or opting for outpatient management where appropriate, would significantly reduce the cost of treatment for microbial keratitis.

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“…In 73,2 % war eine erneute chirurgische Therapie zur Infektionskontrolle notwendig. Für das Gesundheitssystem geht die mykotische Keratitis mit deutlich höheren Behandlungskosten einher als die bakterielle Keratitis [51]. Eine kleine taiwanesische Studie konnte für die Fusarien-Keratitis zeigen, dass bei einer Infiltratgröße von 3-6 mm und Begrenzung auf die vorderen 2 2 ⁄3 3 des Hornhautstromas eine frühe Therapie mittels pKPL die Dauer des Krankenhausaufenthaltes und die Behandlungskosten reduzieren konnte [52].…”

Section: Crosslinking (Cxl) Photodynamische Therapie (Pdt) Und Kornea...unclassified

“…For the healthcare system, mycotic keratitis is associated with significantly higher treatment costs than bacterial keratitis 51 . A small Taiwanese study was able to show for Fusarium keratitis that with an infiltrate size of 3 – 6 mm and limitation to the anterior 2/3 of the corneal stroma, early treatment using PKP could reduce the duration of hospital stay and treatment costs 52 .…”

Section: Prognosismentioning

confidence: 99%

Die Fusarien-Keratitis auf dem Vormarsch – eine aktuelle klinische Übersicht

Khoramnia,

Augustin,

Kovalchuk

et al. 2023

Klin Monbl Augenheilkd

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ZusammenfassungDie Keratitis durch Fusarien stellt in Deutschland ein insgesamt seltenes, aber durch seinen raschen Krankheitsverlauf, die meist verspätete Diagnosestellung und die eingeschränkten konservativen Behandlungsoptionen mittels antimykotischer Therapie ein ernst zu nehmendes Krankheitsbild mit potenziell visusbedrohendem Verlauf dar. Durch die zunehmende Anwendung von Kontaktlinsen und möglicherweise durch die veränderten klimatischen Bedingungen ist ein weiterer Anstieg der Fallzahlen in Deutschland zu erwarten. Das rechtzeitige Erkennen und Einleiten der antimykotischen Therapie und bei ausbleibender Besserung die frühzeitige Durchführung einer notfallmäßigen Keratoplastik sind hierbei maßgeblich für den Therapieerfolg.

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Comparative study on costs incurred for treatment of patients with bacterial and fungal keratitis - A retrospective analysis

Cited by 11 publications

References 14 publications

The Case for Fungal Keratitis to Be Accepted as a Neglected Tropical Disease

The Case for Fungal Keratitis to Be Accepted as a Neglected Tropical Disease

Epidemiology and Economic Cost Analysis of Microbial Keratitis from a Tertiary Referral Hospital in Australia

Die Fusarien-Keratitis auf dem Vormarsch – eine aktuelle klinische Übersicht

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