Comparative Study on Cardiotoxic Effect of Tinuvin 770: A Light Stabilizer of Medical Plastics in Rat Model

Sótonyi, Péter; Merkely, Béla; Hubay, Márta; Járay, J.; Zima, Endre; Soós, Pál; Kovács, Anikó; Szentmariay, I. F

doi:10.1093/toxsci/kfh025

Cited by 23 publications

(9 citation statements)

References 19 publications

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“…In the 1960s it was found that patients with Parkinson's disease show an almost complete depletion of DA in this region [10,15,16]. On the other hand, high levels are known to be cardiotoxic, leading to heart electrophysiology dysfunction [17]. The fact that the DA is easily an oxidizable compound makes its detection possible by electrochemical methods, i.e., using anodic oxidation.…”

Section: Introductionmentioning

confidence: 99%

Incorporating β-Cyclodextrin with ZnO Nanorods: A Potentiometric Strategy for Selectivity and Detection of Dopamine

Elhag

Ibupoto

Nur

et al. 2014

Sensors

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We describe a chemical sensor based on a simple synthesis of zinc oxide nanorods (ZNRs) for the detection of dopamine molecules by a potentiometric approach. The polar nature of dopamine leads to a change of surface charges on the ZNR surface via metal ligand bond formation which results in a measurable electrical signal. ZNRs were grown on a gold-coated glass substrate by a low temperature aqueous chemical growth (ACG) method. Polymeric membranes incorporating β-cyclodextrin (β-CD) and potassium tetrakis (4-chlorophenyl) borate was immobilized on the ZNR surface. The fabricated electrodes were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM) techniques. The grown ZNRs were well aligned and exhibited good crystal quality. The present sensor system displays a stable potential response for the detection of dopamine in 10−2 mol·L−1 acetic acid/sodium acetate buffer solution at pH 5.45 within a wide concentration range of 1 × 10−6 M−1 × 10−1 M, with sensitivity of 49 mV/decade. The electrode shows a good response time (less than 10 s) and excellent repeatability. This finding can contribute to routine analysis in laboratories studying the neuropharmacology of catecholamines. Moreover, the metal-ligand bonds can be further exploited to detect DA receptors, and for bio-imaging applications.

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Section: Introductionmentioning

confidence: 99%

Incorporating β-Cyclodextrin with ZnO Nanorods: A Potentiometric Strategy for Selectivity and Detection of Dopamine

Elhag

Ibupoto

Nur

et al. 2014

Sensors

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“…The mechanism of action of a HALS on radicals is shown in Figure S2. Tinuvin 770 reportedly has L‐type Ca 2+ ‐channel blocker activity, and has thus been studied as an inhibitor of various receptors, and the hazards associated with Tinuvin 770 have been previously studied . The binding of HALSs to proteins was examined, but no effect was found .…”

Section: Discussionmentioning

confidence: 99%

“…Tinuvin 770 reportedly has L-type Ca 2+ -channel blocker activity, and has thus been studied as an inhibitor of various receptors, and the hazards associated with Tinuvin 770 have been previously studied. [7][8][9][10][11][12][13][14][15][16] 16 The binding of HALSs to proteins was examined, but no effect was found. 17 To our knowledge, this is the first report of allergic dermatitis caused by a HALS.…”

Section: Discussionmentioning

confidence: 99%

Contact allergy to Tinuvin 770, a hindered amine light stabilizer in sandals contributing to hyperkeratotic foot dermatitis

et al. 2019

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“…We have previously demonstrated that in vitro Tinuvin-770 has time-dependent cardiotoxic effects on isolated myocardial cells [ 16 ] and dose-dependent chronic cardiotoxicity in rats in vivo [ 17 ]. It was also shown that Tinuvin 770 increased intracellular Ca 2+ accumulation and catecholamine release similarly to the first generation L-type Ca 2+ blockers.…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic Effects of the Light Stabilizer Tinuvin 770 in Dogs In Vivo

Krepuska

Hubay

Zima

et al. 2018

TOMCJ

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Introduction:Tinuvin 770 [bis(2,2,6,6-tetramethyl-4-piperidinyl) sebacate, Ciba-Geigy, Basel, Switzerland] is a UV light stabilizer that is a component of many plastic materials used world-wide in the medical and food industries. We report on the acute hemodynamic effects of Tinuvin 770 examined in dogs.Materials and Methods:Tinuvin 770 was dissolved in a mixture of saline and ethanol (1:1 v/v) and was administered to 12 intravenously narcotized and respirated dogs in increasing doses (T1-T7: 1, 3.3, 6.6, 10, 33.3, 66.6 and 100 mg, respectively). The doses were given as bolus injections over a three minute period, and the effects were recorded for 12 minutes. The vehicle was used as a control. Hemodynamic parameters (heart rate, blood pressure, end-diastolic pressure, dp/dt, cardiac output) and ECG were monitored continously.Results:At doses T1-T4, systolic and diastolic blood pressures, mean pressure and ventricular contractility were significantly decreased without significant changes in cardiac output, heart rate, or PQ interval. At doses T5 and T6, declines in blood pressure and myocardial contractility were observed. At doses T6 and T7, heart rate and PQ interval decreased substantially. Irreversible circulatory failure occured in one dog after administering dose T6 and in 8 dogs following dose T7.Conclusion:Tinuvin 770 induces acute hemodynamic alterations. In lower doses, it causes peripheral vasodilatation, however at higher doses acute cardiac failure occured. Plastics containing Tinuvin 770 should be used with care in medical practice and the laboratory.

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Comparative Study on Cardiotoxic Effect of Tinuvin 770: A Light Stabilizer of Medical Plastics in Rat Model

Cited by 23 publications

References 19 publications

Incorporating β-Cyclodextrin with ZnO Nanorods: A Potentiometric Strategy for Selectivity and Detection of Dopamine

Incorporating β-Cyclodextrin with ZnO Nanorods: A Potentiometric Strategy for Selectivity and Detection of Dopamine

Contact allergy to Tinuvin 770, a hindered amine light stabilizer in sandals contributing to hyperkeratotic foot dermatitis

Hemodynamic Effects of the Light Stabilizer Tinuvin 770 in Dogs In Vivo

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