Comparative study on age-related changes and atherosclerotic involvement of the coronary arteries of male and female subjects up to 40 years of age

Natural Incidence of Interruptions in the Internal Elastic Lamina of Caudal and Renal Arteries of the Rat

“…These gaps are more numerous in the caudal artery than in the renal artery, suggesting the influence of local factors, and are more numerous in the male than in the female. Such a sex difference has been reported by Velican and Velican [1981] concerning the age-related alterations in the IEL in the human coronary artery, and to a lesser extent by Winter et al [1979] in the human external iliac artery.…”

Development of Transplantation Vasculopathy and Progression of Donor-Transmitted Atherosclerosis

“…In a necropsy study, normal intimal thickness (not including media) averaged 0.21 mm (0.10 to 0.28 mm) in 21-to 25-year-old subjects, 0.22 mm (0.12 to 0.28 mm) in 26-to 30-year-old subjects, and 0.25 mm (0.18 to 0.35 mm) in 36-to 40-year-old subjects. 34 Similarly, in a comparative ultrasound-histology study, patients with no known coronary artery disease, intimal thickness (without including media) was 0.24Ϯ0.11 mm. 35 In this study, the medial thickness was 0.23Ϯ0.6 mm and did not vary significantly with intimal proliferation.…”

Mathematical modeling of coupled drug and drug-encapsulated nanoparticle transport in patient-specific coronary artery walls

“…Table 4.1 lists the dimensions of these two constituent layers of a typical Left Anterior Descending (LAD) coronary artery wall for both a healthy and a diseased artery as reported in [53]. The values in parentheses are the averages of all the thickness data taken from histomorphological studies referred to in [54]. Since the thickness of the intima and media vary widely with age, gender, disease condition and stage, etc., it is very difficult to select a representative idealized artery wall model.…”